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. 1978 Apr;75(4):1759–1762. doi: 10.1073/pnas.75.4.1759

"Two out of three": an alternative method for codon reading.

U Lagerkvist
PMCID: PMC392419  PMID: 273907

Abstract

An alternative method for codon reading, whereby only the first two codon nucleotides are recognized by the anticodon, is discussed and the experimental evidence for this "two of three" reading method is reviewed. Misreading of codons by the "two out of three" method could pose a significant threat to the fidelity of protein synthesis unless the genetic code is organized in such a way as to prevent this method from being used when it might compromise translational fidelity. Inspection of the genetic code shows that it is arranged in such a way that the "two out of three" reading method can be used without translational errors.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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