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. 1978 Jun;75(6):2991–2993. doi: 10.1073/pnas.75.6.2991

[Met5]Enkephalin content in brain regions of rats treated with lithium.

J C Gillin, J S Hong, H Y Yang, E Costa
PMCID: PMC392693  PMID: 275866

Abstract

In rats, chronic treatment with lithium elicits a dose-dependent increase in the [Met5]enkephalin content of nucleus caudatus and globus pallidus. A single injection of lithium fails to change the striatal [Met5]enkephalin content. The increase in [Met5]enkephalin caused by chronic lithium is proportional to the serum lithium level. The extent of the increase in striatal [Met5]enkephalin content levels off at a value of about 250% that of untreated rats. This increase has a time latency of 2--3 days and reaches a plateau at 5 days. The increase that was present at 5 days was no longer evident if the treatment was continued for 2 weeks. Lithium also increases striatal [Leu5]enkephalin content by an extent equal to the increase of [Met 5]enkephalin. Based on the characteristics of the lithium-induced increase in [Met6]enkephalin content, it is proposed that lithium may reduce the rate of release of [Met5]enkephalin from the small enkephalinergic neurons that are intrinsic to the striatum; this action may be related to a change in the regulation of striatal neurons.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bunney W. E., Jr Acute behavioral effects of lithium carbonate. Neurosci Res Program Bull. 1976 Apr;14(2):124–131. [PubMed] [Google Scholar]
  2. Davis J. M. Overview: maintenance therapy in psychiatry: II. Affective disorders. Am J Psychiatry. 1976 Jan;133(1):1–13. doi: 10.1176/ajp.133.1.1. [DOI] [PubMed] [Google Scholar]
  3. Friedman E., Gershon S. Effect of lithium on brain dopamine. Nature. 1973 Jun 29;243(5409):520–521. doi: 10.1038/243520a0. [DOI] [PubMed] [Google Scholar]
  4. Guidotti A., Cheney D. L., Trabucchi M., Doteuchi M., Wang C. Focussed microwave radiation: a technique to minimize post mortem changes of cyclic nucleotides, dopa and choline and to preserve brain morphology. Neuropharmacology. 1974 Dec;13(12):1115–1122. doi: 10.1016/0028-3908(74)90061-6. [DOI] [PubMed] [Google Scholar]
  5. Hong J. S., Yang H. Y., Costa E. On the location of methionine enkephalin neurons in rat striatum. Neuropharmacology. 1977 Jun;16(6):451–453. doi: 10.1016/0028-3908(77)90089-2. [DOI] [PubMed] [Google Scholar]
  6. Hong J. S., Yang H. Y., Fratta W., Costa E. Rat striatal methionine-enkephalin content after chronic treatment with cataleptogenic and noncataleptogenic antischizophrenic drugs. J Pharmacol Exp Ther. 1978 Apr;205(1):141–147. [PubMed] [Google Scholar]
  7. Jensen J. The effect of prolonged lithium ingestion on morphine actions in the rat. Acta Pharmacol Toxicol (Copenh) 1974 Nov;35(5):395–402. doi: 10.1111/j.1600-0773.1974.tb00760.x. [DOI] [PubMed] [Google Scholar]
  8. Koslow S. H., Racagni G., Costa E. Mass fragmentographic measurement of norepinephrine dopamine, serotonin and acetylcholine in seven discrete nuclei of the rat tel-diencephalon. Neuropharmacology. 1974 Dec;13(12):1123–1130. doi: 10.1016/0028-3908(74)90062-8. [DOI] [PubMed] [Google Scholar]
  9. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  10. Murphy D. L., Donnelly C., Moskowitz J. Inhibition by lithium of prostaglandin E1 and norepinephrine effects on cyclic adenosine monophosphate production in human platelets. Clin Pharmacol Ther. 1973 Sep-Oct;14(5):810–814. doi: 10.1002/cpt1973145810. [DOI] [PubMed] [Google Scholar]
  11. Palkovits M. Isolated removal of hypothalamic or other brain nuclei of the rat. Brain Res. 1973 Sep 14;59:449–450. doi: 10.1016/0006-8993(73)90290-4. [DOI] [PubMed] [Google Scholar]
  12. Pollard H., Llorens-Cortes C., Schwartz J. C. Enkephalin receptors on dopaminergic neurones in rat striatum. Nature. 1977 Aug 25;268(5622):745–747. doi: 10.1038/268745a0. [DOI] [PubMed] [Google Scholar]
  13. Schou M. Clinical behavioral effects of lithium. Clinical prophylactic effects and clinical pharmacology of lithium. Neurosci Res Program Bull. 1976 Apr;14(2):117–131. [PubMed] [Google Scholar]
  14. Weischer M. L., Opitz K. Abschwächung analgetischer Effekte durch Lithium. Arzneimittelforschung. 1970 Aug;20(8):1046–1048. [PubMed] [Google Scholar]
  15. Yang H. Y., Hong J. S., Costa E. Regional distribution of LEU and MET enkephalin in rat brain. Neuropharmacology. 1977 Apr;16(4):303–307. doi: 10.1016/0028-3908(77)90112-5. [DOI] [PubMed] [Google Scholar]

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