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. 1978 Jul;75(7):3417–3421. doi: 10.1073/pnas.75.7.3417

Direct determination of volume- and time-dependence of alveolar surface tension in excised lungs.

S Schürch, J Goerke, J A Clements
PMCID: PMC392788  PMID: 277943

Abstract

We measured alveolar surface tension directly by observing the spreading properties of fluid droplets placed by micropipette within individual alveoli. Alveolar surface tension in excised rat lungs at total lung capacity and 37 degrees was 29.7 +/- 1.4 mN-m-1. In lungs held at functional residual capacity, surface tension changed slowly, rising to 9 mN-m-1 at 30 min with a subsequent approximately linear rise to 16 mN-m-1 at 115 min. Thereafter it rose more rapidly (20 mN-m-1 at 140 min), suggesting that it was not asymptotically approaching an equilibrium value.

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Selected References

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  1. ANTHONISEN N. R. CHANGES IN SHUNT FLOW, COMPLIANCE, AND VOLUME OF LUNGS DURING APNEIC OXYGENATION. Am J Physiol. 1964 Jul;207:235–238. doi: 10.1152/ajplegacy.1964.207.1.235. [DOI] [PubMed] [Google Scholar]
  2. AVERY M. E., MEAD J. Surface properties in relation to atelectasis and hyaline membrane disease. AMA J Dis Child. 1959 May;97(5 Pt 1):517–523. doi: 10.1001/archpedi.1959.02070010519001. [DOI] [PubMed] [Google Scholar]
  3. Bachofen H., Hildebrandt J., Bachofen M. Pressure-volume curves of air- and liquid-filled excised lungs-surface tension in situ. J Appl Physiol. 1970 Oct;29(4):422–431. doi: 10.1152/jappl.1970.29.4.422. [DOI] [PubMed] [Google Scholar]
  4. CLEMENTS J. A. Surface phenomena in relation to pulmonary function. Physiologist. 1962 Feb;5:11–28. [PubMed] [Google Scholar]
  5. CLEMENTS J. A. Surface tension of lung extracts. Proc Soc Exp Biol Med. 1957 May;95(1):170–172. doi: 10.3181/00379727-95-23156. [DOI] [PubMed] [Google Scholar]
  6. Fisher M. J., Wilson M. F., Weber K. C. Determination of alveolar surface area and tension from in situ pressure-volume data. Respir Physiol. 1970 Sep;10(2):159–171. doi: 10.1016/0034-5687(70)90080-0. [DOI] [PubMed] [Google Scholar]
  7. Goerke J. Lung surfactant. Biochim Biophys Acta. 1974 Dec 16;344(3-4):241–261. doi: 10.1016/0304-4157(74)90009-4. [DOI] [PubMed] [Google Scholar]
  8. Horie T., Hildebrandt J. Dynamic compliance, limit cycles, and static equilibria of excised cat lung. J Appl Physiol. 1971 Sep;31(3):423–430. doi: 10.1152/jappl.1971.31.3.423. [DOI] [PubMed] [Google Scholar]
  9. Lempert J., Macklem P. T. Effect of temperature on rabbit lung surfactant and pressure-volume hysteresis. J Appl Physiol. 1971 Sep;31(3):380–385. doi: 10.1152/jappl.1971.31.3.380. [DOI] [PubMed] [Google Scholar]
  10. Notter R. H., Morrow P. E. Pulmonary surfactant: a surface chemistry viewpoint. Ann Biomed Eng. 1975 Jun;3(2):119–159. doi: 10.1007/BF02363067. [DOI] [PubMed] [Google Scholar]
  11. PATTLE R. E. Properties, function and origin of the alveolar lining layer. Nature. 1955 Jun 25;175(4469):1125–1126. doi: 10.1038/1751125b0. [DOI] [PubMed] [Google Scholar]
  12. Schoedel W., Slama H., Hansen E. Zeitabhängiges Verhalten von Filmen von oberflächenaktivem Material aus Lungenalveolen. Pflugers Arch. 1971;322(4):336–346. doi: 10.1007/BF00587751. [DOI] [PubMed] [Google Scholar]
  13. Schürch S., Goerke J., Clements J. A. Direct determination of surface tension in the lung. Proc Natl Acad Sci U S A. 1976 Dec;73(12):4698–4702. doi: 10.1073/pnas.73.12.4698. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Stemmler E. J., DuBois A. B. Pulmonary tissue and surface elastic forces at low lung volumes in rabbits. J Appl Physiol. 1968 Nov;25(5):473–478. doi: 10.1152/jappl.1968.25.5.473. [DOI] [PubMed] [Google Scholar]
  15. TIERNEY D. F. PULMONARY SURFACTANT IN HEALTH AND DISEASE. Dis Chest. 1965 Mar;47:247–253. doi: 10.1378/chest.47.3.247. [DOI] [PubMed] [Google Scholar]
  16. Watkins J. C. The surface properties of pure phospholipids in relation to those of lung extracts. Biochim Biophys Acta. 1968 Mar 4;152(2):293–306. doi: 10.1016/0005-2760(68)90037-4. [DOI] [PubMed] [Google Scholar]

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