Abstract
A closed duplex DNA molecule relaxed and containing nucleosomes has a different linking number from the same molecule relaxed and without nucleosomes. What does this say about the structure of the nucleosome? A mathematical study of this question is made, representing the DNA molecule by a ribbon. It is shown that the linking number of a closed ribbon can be decomposed into the linking number of a reference ribbon plus a sum of locally determined “linking differences.”
Keywords: writhing number, DNA, nucleosome
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Crick F. H. Linking numbers and nucleosomes. Proc Natl Acad Sci U S A. 1976 Aug;73(8):2639–2643. doi: 10.1073/pnas.73.8.2639. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Frank-Kamenetskii M. D., Lukashin A. V., Vologodskii A. V. Statistical mechanics and topology of polymer chains. Nature. 1975 Dec 4;258(5534):398–402. doi: 10.1038/258398a0. [DOI] [PubMed] [Google Scholar]
- Fuller F. B. The writhing number of a space curve. Proc Natl Acad Sci U S A. 1971 Apr;68(4):815–819. doi: 10.1073/pnas.68.4.815. [DOI] [PMC free article] [PubMed] [Google Scholar]