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. 1978 Nov;75(11):5457–5461. doi: 10.1073/pnas.75.11.5457

Inhibition of growth of 3T3 cells by extract of surface membranes.

B Whittenberger, D Raben, M A Lieberman, L Glaser
PMCID: PMC392983  PMID: 281694

Abstract

The growth of Swiss 3T3 cells can be inhibited by the addition of a plasma membrane enriched fraction from 3T3 cells [Whittenberger, B & Glaser, L. (1977) Proc. Natl. Acad. Sci. USA 74, 2251--2255]. We report conditions for the extraction of the inhibitory components from the membranes with octylglucoside. The solubilized components reversibly inhibit the rate of cell division of 3T3 but not of simian virus 40-transformed 3T3 cells. The inhibitory activity is heat labile and nondialyzable. The inhibition observed with the soluble extract can be reversed by mitogenic factors present in serum.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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