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. 1983 May;80(9):2723–2727. doi: 10.1073/pnas.80.9.2723

Normal mice express idiotypes related to autoantibody idiotypes of lupus mice

Syamal K Datta *, B David Stollar †, Robert S Schwartz *
PMCID: PMC393900  PMID: 6601804

Abstract

Spleen and fetal liver B cells of normal mice synthesized idiotypes shared by anti-DNA autoantibodies of genetically autoimmune mice. Some of the idiotypes were specific for DNA; the majority, however, were not. The findings indicate that the autoantibody idiotypes are related to a conserved family of antibody variable regions that are present in normal animals.

Keywords: monoclonal anti-DNA autoantibodies, shared idiotypes, autoimmunity

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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