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. 1983 Jun;80(11):3466–3469. doi: 10.1073/pnas.80.11.3466

Modification of T-cell proliferation and interleukin 2 production in mice infected with Trypanosoma cruzi.

A Harel-Bellan, M Joskowicz, D Fradelizi, H Eisen
PMCID: PMC394065  PMID: 6407015

Abstract

Acute infection of mice with Trypanosoma cruzi results in severe immunodepression and the appearance of autoimmune symptoms. In vitro, concanavalin A-stimulated T cells from spleens of infected animals could neither produce nor respond to interleukin 2. Interleukin 2 production was not restored by addition of exogenous interleukin 1, and proliferative response to concanavalin A was not restored by exogenous interleukin 2. A population of Thy-1-negative cells in the spleen of infected animals was shown to suppress the concanavalin A proliferative response and, to a lesser extent, the production of interleukin 2. These and other symptoms of T. cruzi-infected mice are similar to the immune dysfunction of autoimmune lpr/lpr mice. These findings are discussed in relationship to the pathology of Chagas disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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