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. 1985 Jan;82(1):183–187. doi: 10.1073/pnas.82.1.183

Identification of a unique B-cell-stimulating factor produced by a cloned dendritic cell.

C Clayberger, R H DeKruyff, R Fay, H Cantor
PMCID: PMC396996  PMID: 3871522

Abstract

We describe a cloned dendritic cell, clone Den-1, which is a potent accessory cell for some B-cell responses. Clone Den-1 produces a unique lymphokine that induces polyclonal B-cell proliferation in the absence of other costimulators. This clone or factors produced by it also stimulate purified B cells to develop plaque-forming cell responses to type 2 antigens. The effect of this factor(s) on various B-cell populations and its relationship to previously described B-cell-stimulating factors is discussed.

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Selected References

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