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. 1985 Jan;82(2):536–538. doi: 10.1073/pnas.82.2.536

Acquired immunological tolerance of foreign cells is impaired by recombinant interleukin 2 or vitamin A acetate.

M Malkovský, P B Medawar, D R Thatcher, J Toy, R Hunt, L S Rayfield, C Doré
PMCID: PMC397074  PMID: 3881767

Abstract

The susceptibility of newborn mice to the inception of tolerance after exposure to antigen is associated with their deficiency in the production of endogenous interleukin 2 (IL-2). As further evidence of the complicity of IL-2 in the inception and maintenance of tolerance, it is shown here that a solid and long-lasting state of tolerance induced by the intravenous injection into newborn CBA mice of lymphoid cells from (CBA X C57BL/10ScSn)F1 hybrids can be brought to an end by the administration of exogenous IL-2 or by supplementing an otherwise normal diet with vitamin A acetate, the effect of which is to increase the proportion of the moiety of the T-cell population that produces IL-2. These results indicate that certain nonspecific stimuli can influence whether immunological tolerance is maintained.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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