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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1985 Mar;82(6):1852–1854. doi: 10.1073/pnas.82.6.1852

Isolation of morphine from toad skin.

K Oka, J D Kantrowitz, S Spector
PMCID: PMC397372  PMID: 3920656

Abstract

A nonpeptide opioid was found in toad skin and purified to homogeneity by using HPLC with electrochemical detection. A nonpeptide opioid also was detected in bovine brain and adrenals as well as rabbit and rat skin, by reversed-phase HPLC following Sephadex G-15 column chromatography. The material in toad skin was identical to morphine by immunological, pharmacological, and physical chemical criteria.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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