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. 1989 Sep;8(9):2559–2566. doi: 10.1002/j.1460-2075.1989.tb08394.x

Autoregulation of fos: the dyad symmetry element as the major target of repression.

H König 1, H Ponta 1, U Rahmsdorf 1, M Büscher 1, A Schönthal 1, H J Rahmsdorf 1, P Herrlich 1
PMCID: PMC401256  PMID: 2511006

Abstract

Fos and Jun co-operatively repress the fos promoter. Removal of all putative Fos/Jun binding sites from the fos promoter neither obliterates the repression by Fos/Jun in transient cotransfection experiments in NIH3T3 cells nor the turn-off kinetics of serum-induced fos expression in stably transfected NIH3T3 cells. The dyad symmetry element (DSE) suffices to subject a promoter to this type of repression. However, one of the putative Fos/Jun binding sites (-292 to -299 and thus located immediately adjacent to the DSE), determines the very low level of basal expression.

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Selected References

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