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. 1989 Nov;8(11):3401–3407. doi: 10.1002/j.1460-2075.1989.tb08504.x

Autoregulation of RNase III operon by mRNA processing.

J C Bardwell 1, P Régnier 1, S M Chen 1, Y Nakamura 1, M Grunberg-Manago 1, D L Court 1
PMCID: PMC401487  PMID: 2583104

Abstract

RNase III has been implicated in the control of gene expression by the processing of mRNA. We have found that the rnc operon is autoregulated; rnc- mutant strains oversynthesize the operon's mRNA and protein products. A site in the 5'-noncoding region of the operon's message is cleaved by RNase III. This site-specific cleavage appears to be the initial step in the functional inactivation of the message, since the half-life of the cut message is dramatically shorter than that of the uncut message.

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