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. 1995 Dec 19;92(26):12480–12484. doi: 10.1073/pnas.92.26.12480

Steroid receptor heterodimerization demonstrated in vitro and in vivo.

W Liu 1, J Wang 1, N K Sauter 1, D Pearce 1
PMCID: PMC40381  PMID: 8618925

Abstract

The mineralocorticoid and glucocorticoid receptors (MR and GR, respectively) are members of the intracellular receptor superfamily that bind as homodimers to the same hormone response elements (HREs). Physiological evidence suggests that MR and GR interact with each other in cells that express both receptors, implying that they might directly interact in the regulation of transcription initiation. Indeed, we have found that coexpressed MR and GR interact functionally at the transcriptional level and furthermore that they interact physically through heterodimer formation at a shared HRE in vitro and in vivo. We suggest from these findings that heterodimerization may play an important role in steroid receptor transcriptional regulation.

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Selected References

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