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. 1996 Jun;49(3):M126–M135. doi: 10.1136/mp.49.3.m126

Protein glycosylation in cancer biology: an overview

F Dall'Olio 1
PMCID: PMC408038  PMID: 16696060

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M126

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Benedetto A., Elia G., Sala A., Belardelli F. Hyposialylation of high-molecular-weight membrane glycoproteins parallels the loss of metastatic potential in wheat-germ agglutinin-resistant Friend leukemia cells. Int J Cancer. 1989 Jan 15;43(1):126–133. doi: 10.1002/ijc.2910430124. [DOI] [PubMed] [Google Scholar]
  2. Berg E. L., Robinson M. K., Mansson O., Butcher E. C., Magnani J. L. A carbohydrate domain common to both sialyl Le(a) and sialyl Le(X) is recognized by the endothelial cell leukocyte adhesion molecule ELAM-1. J Biol Chem. 1991 Aug 15;266(23):14869–14872. [PubMed] [Google Scholar]
  3. Blasco E., Torrado J., Belloso L., Arocena F., Gutierrez-Hoyos A., Cuadrado E. T-antigen. A prognostic indicator of high recurrence index in transitional carcinoma of the bladder. Cancer. 1988 Mar 15;61(6):1091–1095. doi: 10.1002/1097-0142(19880315)61:6<1091::aid-cncr2820610607>3.0.co;2-f. [DOI] [PubMed] [Google Scholar]
  4. Boland C. R., Montgomery C. K., Kim Y. S. Alterations in human colonic mucin occurring with cellular differentiation and malignant transformation. Proc Natl Acad Sci U S A. 1982 Mar;79(6):2051–2055. doi: 10.1073/pnas.79.6.2051. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Bresalier R. S., Rockwell R. W., Dahiya R., Duh Q. Y., Kim Y. S. Cell surface sialoprotein alterations in metastatic murine colon cancer cell lines selected in an animal model for colon cancer metastasis. Cancer Res. 1990 Feb 15;50(4):1299–1307. [PubMed] [Google Scholar]
  6. Brockhausen I. Clinical aspects of glycoprotein biosynthesis. Crit Rev Clin Lab Sci. 1993;30(2):65–151. doi: 10.3109/10408369309084666. [DOI] [PubMed] [Google Scholar]
  7. Brockhausen I., Kuhns W., Schachter H., Matta K. L., Sutherland D. R., Baker M. A. Biosynthesis of O-glycans in leukocytes from normal donors and from patients with leukemia: increase in O-glycan core 2 UDP-GlcNAc:Gal beta 3 GalNAc alpha-R (GlcNAc to GalNAc) beta(1-6)-N-acetylglucosaminyltransferase in leukemic cells. Cancer Res. 1991 Feb 15;51(4):1257–1263. [PubMed] [Google Scholar]
  8. Cho S. H., Sahin A., Hortobagyi G. N., Hittelman W. N., Dhingra K. Sialyl-Tn antigen expression occurs early during human mammary carcinogenesis and is associated with high nuclear grade and aneuploidy. Cancer Res. 1994 Dec 15;54(24):6302–6305. [PubMed] [Google Scholar]
  9. Collard J. G., Schijven J. F., Bikker A., La Riviere G., Bolscher J. G., Roos E. Cell surface sialic acid and the invasive and metastatic potential of T-cell hybridomas. Cancer Res. 1986 Jul;46(7):3521–3527. [PubMed] [Google Scholar]
  10. Collard J. G., van Beek W. P., Janssen J. W., Schijven J. F. Transfection by human oncogenes: concomitant induction of tumorigenicity and tumor-associated membrane alterations. Int J Cancer. 1985 Feb 15;35(2):207–213. doi: 10.1002/ijc.2910350211. [DOI] [PubMed] [Google Scholar]
  11. Coon J. S., Weinstein R. S., Summers J. L. Blood group precursor T-antigen expression in human urinary bladder carcinoma. Am J Clin Pathol. 1982 Jun;77(6):692–699. doi: 10.1093/ajcp/77.6.692. [DOI] [PubMed] [Google Scholar]
  12. Cooper H. S., Malecha M. J., Bass C., Fagel P. L., Steplewski Z. Expression of blood group antigens H-2, Le(y), and sialylated-Le(a) in human colorectal carcinoma. An immunohistochemical study using double-labeling techniques. Am J Pathol. 1991 Jan;138(1):103–110. [PMC free article] [PubMed] [Google Scholar]
  13. Cordon-Cardo C., Reuter V. E., Finstad C. L., Sheinfeld J., Lloyd K. O., Fair W. R., Melamed M. R. Blood group-related antigens in human kidney: modulation of Lewis determinants in renal cell carcinoma. Cancer Res. 1989 Jan 1;49(1):212–218. [PubMed] [Google Scholar]
  14. Cornil I., Kerbel R. S., Dennis J. W. Tumor cell surface beta 1-4-linked galactose binds to lectin(s) on microvascular endothelial cells and contributes to organ colonization. J Cell Biol. 1990 Aug;111(2):773–781. doi: 10.1083/jcb.111.2.773. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Dall'Olio F., Chiricolo M., Lollini P., Lau J. T. Human colon cancer cell lines permanently expressing alpha 2,6-sialylated sugar chains by transfection with rat beta-galactoside alpha 2,6 sialyltransferase cDNA. Biochem Biophys Res Commun. 1995 Jun 15;211(2):554–561. doi: 10.1006/bbrc.1995.1849. [DOI] [PubMed] [Google Scholar]
  16. Dall'Olio F., Malagolini N., Di Stefano G., Ciambella M., Serafini-Cessi F. Postnatal development of rat colon epithelial cells is associated with changes in the expression of the beta 1,4-N-acetylgalactosaminyltransferase involved in the synthesis of Sda antigen of alpha 2,6-sialyltransferase activity towards N-acetyl-lactosamine. Biochem J. 1990 Sep 1;270(2):519–524. doi: 10.1042/bj2700519. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Dall'Olio F., Malagolini N., Serafini-Cessi F. Enhanced CMP-NeuAc:Gal beta 1,4GlcNAc-R alpha 2,6 sialyltransferase activity of human colon cancer xenografts in athymic nude mice and of xenograft-derived cell lines. Int J Cancer. 1992 Jan 21;50(2):325–330. doi: 10.1002/ijc.2910500227. [DOI] [PubMed] [Google Scholar]
  18. Dall'Olio F., Malagolini N., Serafini-Cessi F. The expression of soluble and cell-bound alpha 2,6 sialyltransferase in human colonic carcinoma CaCo-2 cells correlates with the degree of enterocytic differentiation. Biochem Biophys Res Commun. 1992 May 15;184(3):1405–1410. doi: 10.1016/s0006-291x(05)80039-7. [DOI] [PubMed] [Google Scholar]
  19. Dall'Olio F., Malagolini N., di Stefano G., Minni F., Marrano D., Serafini-Cessi F. Increased CMP-NeuAc:Gal beta 1,4GlcNAc-R alpha 2,6 sialyltransferase activity in human colorectal cancer tissues. Int J Cancer. 1989 Sep 15;44(3):434–439. doi: 10.1002/ijc.2910440309. [DOI] [PubMed] [Google Scholar]
  20. Dall'Olio F., Trerè D. Expression of alpha 2,6-sialylated sugar chains in normal and neoplastic colon tissues. Detection by digoxigenin-conjugated Sambucus nigra agglutinin. Eur J Histochem. 1993;37(3):257–265. [PubMed] [Google Scholar]
  21. David L., Leitao D., Sobrinho-Simoes M., Bennett E. P., White T., Mandel U., Dabelsteen E., Clausen H. Biosynthetic basis of incompatible histo-blood group A antigen expression: anti-A transferase antibodies reactive with gastric cancer tissue of type O individuals. Cancer Res. 1993 Nov 15;53(22):5494–5500. [PubMed] [Google Scholar]
  22. Dejana E., Martin-Padura I., Lauri D., Bernasconi S., Bani M. R., Garofalo A., Giavazzi R., Magnani J., Mantovani A., Menard S. Endothelial leukocyte adhesion molecule-1-dependent adhesion of colon carcinoma cells to vascular endothelium is inhibited by an antibody to Lewis fucosylated type I carbohydrate chain. Lab Invest. 1992 Mar;66(3):324–330. [PubMed] [Google Scholar]
  23. Dennis J. W., Carver J. P., Schachter H. Asparagine-linked oligosaccharides in murine tumor cells: comparison of a WGA-resistant (WGAr) nonmetastatic mutant and a related WGA-sensitive (WGAs) metastatic line. J Cell Biol. 1984 Sep;99(3):1034–1044. doi: 10.1083/jcb.99.3.1034. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Dennis J. W. Different metastatic phenotypes in two genetic classes of wheat germ agglutinin-resistant tumor cell mutants. Cancer Res. 1986 Sep;46(9):4594–4600. [PubMed] [Google Scholar]
  25. Dennis J. W. Effects of swainsonine and polyinosinic:polycytidylic acid on murine tumor cell growth and metastasis. Cancer Res. 1986 Oct;46(10):5131–5136. [PubMed] [Google Scholar]
  26. Dennis J. W., Koch K., Beckner D. Inhibition of human HT29 colon carcinoma growth in vitro and in vivo by swainsonine and human interferon-alpha 2. J Natl Cancer Inst. 1989 Jul 5;81(13):1028–1033. doi: 10.1093/jnci/81.13.1028. [DOI] [PubMed] [Google Scholar]
  27. Dennis J. W., Koch K., Yousefi S., VanderElst I. Growth inhibition of human melanoma tumor xenografts in athymic nude mice by swainsonine. Cancer Res. 1990 Mar 15;50(6):1867–1872. [PubMed] [Google Scholar]
  28. Dennis J. W., Laferté S., Fukuda M., Dell A., Carver J. P. Asn-linked oligosaccharides in lectin-resistant tumor-cell mutants with varying metastatic potential. Eur J Biochem. 1986 Dec 1;161(2):359–373. doi: 10.1111/j.1432-1033.1986.tb10455.x. [DOI] [PubMed] [Google Scholar]
  29. Dennis J. W., Laferté S., Waghorne C., Breitman M. L., Kerbel R. S. Beta 1-6 branching of Asn-linked oligosaccharides is directly associated with metastasis. Science. 1987 May 1;236(4801):582–585. doi: 10.1126/science.2953071. [DOI] [PubMed] [Google Scholar]
  30. Dennis J. W. Partial reversion of the metastatic phenotype in a wheat germ agglutinin-resistant mutant of the murine tumor cell line MDAY-D2 selected with Bandeiraea simplicifolia seed lectin. J Natl Cancer Inst. 1985 May;74(5):1111–1120. [PubMed] [Google Scholar]
  31. Dennis J., Waller C., Timpl R., Schirrmacher V. Surface sialic acid reduces attachment of metastatic tumour cells to collagen type IV and fibronectin. Nature. 1982 Nov 18;300(5889):274–276. doi: 10.1038/300274a0. [DOI] [PubMed] [Google Scholar]
  32. Easton E. W., Bolscher J. G., van den Eijnden D. H. Enzymatic amplification involving glycosyltransferases forms the basis for the increased size of asparagine-linked glycans at the surface of NIH 3T3 cells expressing the N-ras proto-oncogene. J Biol Chem. 1991 Nov 15;266(32):21674–21680. [PubMed] [Google Scholar]
  33. Feizi T. Demonstration by monoclonal antibodies that carbohydrate structures of glycoproteins and glycolipids are onco-developmental antigens. Nature. 1985 Mar 7;314(6006):53–57. doi: 10.1038/314053a0. [DOI] [PubMed] [Google Scholar]
  34. Fenlon S., Ellis I. O., Bell J., Todd J. H., Elston C. W., Blamey R. W. Helix pomatia and Ulex europeus lectin binding in human breast carcinoma. J Pathol. 1987 Jul;152(3):169–176. doi: 10.1002/path.1711520305. [DOI] [PubMed] [Google Scholar]
  35. Fernandes B., Sagman U., Auger M., Demetrio M., Dennis J. W. Beta 1-6 branched oligosaccharides as a marker of tumor progression in human breast and colon neoplasia. Cancer Res. 1991 Jan 15;51(2):718–723. [PubMed] [Google Scholar]
  36. Figarella-Branger D. F., Durbec P. L., Rougon G. N. Differential spectrum of expression of neural cell adhesion molecule isoforms and L1 adhesion molecules on human neuroectodermal tumors. Cancer Res. 1990 Oct 1;50(19):6364–6370. [PubMed] [Google Scholar]
  37. Finne J., Mäkelä P. H. Cleavage of the polysialosyl units of brain glycoproteins by a bacteriophage endosialidase. Involvement of a long oligosaccharide segment in molecular interactions of polysialic acid. J Biol Chem. 1985 Jan 25;260(2):1265–1270. [PubMed] [Google Scholar]
  38. Foxall C., Watson S. R., Dowbenko D., Fennie C., Lasky L. A., Kiso M., Hasegawa A., Asa D., Brandley B. K. The three members of the selectin receptor family recognize a common carbohydrate epitope, the sialyl Lewis(x) oligosaccharide. J Cell Biol. 1992 May;117(4):895–902. doi: 10.1083/jcb.117.4.895. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. Fukuda M. Cell surface glycoconjugates as onco-differentiation markers in hematopoietic cells. Biochim Biophys Acta. 1985;780(2):119–150. doi: 10.1016/0304-419x(84)90002-7. [DOI] [PubMed] [Google Scholar]
  40. Fukuda M. Leukosialin, a major O-glycan-containing sialoglycoprotein defining leukocyte differentiation and malignancy. Glycobiology. 1991 Sep;1(4):347–356. doi: 10.1093/glycob/1.4.347. [DOI] [PubMed] [Google Scholar]
  41. Gallagher J. T., Morris A., Dexter T. M. Identification of two binding sites for wheat-germ agglutinin on polylactosamine-type oligosaccharides. Biochem J. 1985 Oct 1;231(1):115–122. doi: 10.1042/bj2310115. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Gessner P., Riedl S., Quentmaier A., Kemmner W. Enhanced activity of CMP-neuAc:Gal beta 1-4GlcNAc:alpha 2,6-sialyltransferase in metastasizing human colorectal tumor tissue and serum of tumor patients. Cancer Lett. 1993 Dec 20;75(3):143–149. doi: 10.1016/0304-3835(93)90056-f. [DOI] [PubMed] [Google Scholar]
  43. Goss P. E., Baptiste J., Fernandes B., Baker M., Dennis J. W. A phase I study of swainsonine in patients with advanced malignancies. Cancer Res. 1994 Mar 15;54(6):1450–1457. [PubMed] [Google Scholar]
  44. Greenwell P., Yates A. D., Watkins W. M. UDP-N-acetyl-D-galactosamine as a donor substrate for the glycosyltransferase encoded by the B gene at the human blood group ABO locus. Carbohydr Res. 1986 Jun 1;149(1):149–170. doi: 10.1016/s0008-6215(00)90375-6. [DOI] [PubMed] [Google Scholar]
  45. Gu J., Nishikawa A., Fujii S., Gasa S., Taniguchi N. Biosynthesis of blood group I and i antigens in rat tissues. Identification of a novel beta 1-6-N-acetylglucosaminyltransferase. J Biol Chem. 1992 Feb 15;267(5):2994–2999. [PubMed] [Google Scholar]
  46. Gwin J. L., Klein-Szanto A. J., Zhang S. Y., Agarwal P., Rogatko A., Keller S. M. Loss of blood group antigen A in non-small cell lung cancer. Ann Surg Oncol. 1994 Sep;1(5):423–427. doi: 10.1007/BF02303816. [DOI] [PubMed] [Google Scholar]
  47. Hakomori S. Aberrant glycosylation in tumors and tumor-associated carbohydrate antigens. Adv Cancer Res. 1989;52:257–331. doi: 10.1016/s0065-230x(08)60215-8. [DOI] [PubMed] [Google Scholar]
  48. Hakomori S., Patterson C. M., Nudelman E., Sekiguchi K. A monoclonal antibody directed to N-acetylneuraminosyl-alpha 2 leads to 6-galactosyl residue in gangliosides and glycoproteins. J Biol Chem. 1983 Oct 10;258(19):11819–11822. [PubMed] [Google Scholar]
  49. Hanisch F. G., Hanski C., Hasegawa A. Sialyl Lewis(x) antigen as defined by monoclonal antibody AM-3 is a marker of dysplasia in the colonic adenoma-carcinoma sequence. Cancer Res. 1992 Jun 1;52(11):3138–3144. [PubMed] [Google Scholar]
  50. Hasegawa H., Watanabe M., Arisawa Y., Teramoto T., Kodaira S., Kitajima M. Carbohydrate antigens and liver metastasis in colorectal cancer. Jpn J Clin Oncol. 1993 Dec;23(6):336–341. [PubMed] [Google Scholar]
  51. Heffernan M., Yousefi S., Dennis J. W. Molecular characterization of P2B/LAMP-1, a major protein target of a metastasis-associated oligosaccharide structure. Cancer Res. 1989 Nov 1;49(21):6077–6084. [PubMed] [Google Scholar]
  52. Hoff S. D., Matsushita Y., Ota D. M., Cleary K. R., Yamori T., Hakomori S., Irimura T. Increased expression of sialyl-dimeric LeX antigen in liver metastases of human colorectal carcinoma. Cancer Res. 1989 Dec 15;49(24 Pt 1):6883–6888. [PubMed] [Google Scholar]
  53. Humphries M. J., Matsumoto K., White S. L., Molyneux R. J., Olden K. Augmentation of murine natural killer cell activity by swainsonine, a new antimetastatic immunomodulator. Cancer Res. 1988 Mar 15;48(6):1410–1415. [PubMed] [Google Scholar]
  54. Humphries M. J., Matsumoto K., White S. L., Olden K. Inhibition of experimental metastasis by castanospermine in mice: blockage of two distinct stages of tumor colonization by oligosaccharide processing inhibitors. Cancer Res. 1986 Oct;46(10):5215–5222. [PubMed] [Google Scholar]
  55. Humphries M. J., Matsumoto K., White S. L., Olden K. Oligosaccharide modification by swainsonine treatment inhibits pulmonary colonization by B16-F10 murine melanoma cells. Proc Natl Acad Sci U S A. 1986 Mar;83(6):1752–1756. doi: 10.1073/pnas.83.6.1752. [DOI] [PMC free article] [PubMed] [Google Scholar]
  56. Ikeda Y., Kuwano H., Baba K., Ikebe M., Matushima T., Adachi Y., Mori M., Sugimachi K. Expression of Sialyl-Tn antigens in normal squamous epithelium, dysplasia, and squamous cell carcinoma in the esophagus. Cancer Res. 1993 Apr 1;53(7):1706–1708. [PubMed] [Google Scholar]
  57. Inoue M., Ogawa H., Tanizawa O., Kobayashi Y., Tsujimoto M., Tsujimura T. Immunodetection of sialyl-Tn antigen in normal, hyperplastic and cancerous tissues of the uterine endometrium. Virchows Arch A Pathol Anat Histopathol. 1991;418(2):157–162. doi: 10.1007/BF01600291. [DOI] [PubMed] [Google Scholar]
  58. Inoue M., Ton S. M., Ogawa H., Tanizawa O. Expression of Tn and sialyl-Tn antigens in tumor tissues of the ovary. Am J Clin Pathol. 1991 Dec;96(6):711–716. doi: 10.1093/ajcp/96.6.711. [DOI] [PubMed] [Google Scholar]
  59. Irimura T., Gonzalez R., Nicolson G. L. Effects of tunicamycin on B16 metastatic melanoma cell surface glycoproteins and blood-borne arrest and survival properties. Cancer Res. 1981 Sep;41(9 Pt 1):3411–3418. [PubMed] [Google Scholar]
  60. Irimura T., Tressler R. J., Nicolson G. L. Sialoglycoproteins of murine RAW117 large cell lymphoma/lymphosarcoma sublines of various metastatic colonization properties. Exp Cell Res. 1986 Aug;165(2):403–416. doi: 10.1016/0014-4827(86)90594-x. [DOI] [PubMed] [Google Scholar]
  61. Ishikawa M., Dennis J. W., Man S., Kerbel R. S. Isolation and characterization of spontaneous wheat germ agglutinin-resistant human melanoma mutants displaying remarkably different metastatic profiles in nude mice. Cancer Res. 1988 Feb 1;48(3):665–670. [PubMed] [Google Scholar]
  62. Ishikawa M., Kerbel R. S. Characterization of a metastasis-deficient lectin-resistant human melanoma mutant. Int J Cancer. 1989 Jan 15;43(1):134–139. doi: 10.1002/ijc.2910430125. [DOI] [PubMed] [Google Scholar]
  63. Itai S., Nishikata J., Takahashi N., Tanaka O., Matsubara Y., Hasegawa S., Yanai N., Takaoka K., Arii S., Tobe T. Differentiation-dependent expression of I and sialyl I antigens in the developing lung of human embryos and in lung cancers. Cancer Res. 1990 Dec 1;50(23):7603–7611. [PubMed] [Google Scholar]
  64. Itzkowitz S. H., Bloom E. J., Kokal W. A., Modin G., Hakomori S., Kim Y. S. Sialosyl-Tn. A novel mucin antigen associated with prognosis in colorectal cancer patients. Cancer. 1990 Nov 1;66(9):1960–1966. doi: 10.1002/1097-0142(19901101)66:9<1960::aid-cncr2820660919>3.0.co;2-x. [DOI] [PubMed] [Google Scholar]
  65. Itzkowitz S. H., Yuan M., Ferrell L. D., Ratcliffe R. M., Chung Y. S., Satake K., Umeyama K., Jones R. T., Kim Y. S. Cancer-associated alterations of blood group antigen expression in the human pancreas. J Natl Cancer Inst. 1987 Sep;79(3):425–434. [PubMed] [Google Scholar]
  66. Itzkowitz S. H., Yuan M., Montgomery C. K., Kjeldsen T., Takahashi H. K., Bigbee W. L., Kim Y. S. Expression of Tn, sialosyl-Tn, and T antigens in human colon cancer. Cancer Res. 1989 Jan 1;49(1):197–204. [PubMed] [Google Scholar]
  67. Itzkowitz S. Carbohydrate changes in colon carcinoma. APMIS Suppl. 1992;27:173–180. [PubMed] [Google Scholar]
  68. Itzkowitz S., Kjeldsen T., Friera A., Hakomori S., Yang U. S., Kim Y. S. Expression of Tn, sialosyl Tn, and T antigens in human pancreas. Gastroenterology. 1991 Jun;100(6):1691–1700. doi: 10.1016/0016-5085(91)90671-7. [DOI] [PubMed] [Google Scholar]
  69. Jass J. R., Allison L. M., Edgar S. Monoclonal antibody TKH2 to the cancer-associated epitope sialosyl Tn shows cross-reactivity with variants of normal colorectal goblet cell mucin. Pathology. 1994 Oct;26(4):418–422. doi: 10.1080/00313029400169112. [DOI] [PubMed] [Google Scholar]
  70. Jiang M. S., Passaniti A., Penno M. B., Hart G. W. Adrenal carcinoma tumor progression and penultimate cell surface oligosaccharides. Cancer Res. 1992 Apr 15;52(8):2222–2227. [PubMed] [Google Scholar]
  71. Jordon D., Jagirdar J., Kaneko M. Blood group antigens, Lewisx and Lewisy in the diagnostic discrimination of malignant mesothelioma versus adenocarcinoma. Am J Pathol. 1989 Nov;135(5):931–937. [PMC free article] [PubMed] [Google Scholar]
  72. Kageshita T., Hirai S., Kimura T., Hanai N., Ohta S., Ono T. Association between sialyl Lewis(a) expression and tumor progression in melanoma. Cancer Res. 1995 Apr 15;55(8):1748–1751. [PubMed] [Google Scholar]
  73. Kakeji Y., Maehara Y., Morita M., Matsukuma A., Furusawa M., Takahashi I., Kusumoto T., Ohno S., Sugimachi K. Correlation between sialyl Tn antigen and lymphatic metastasis in patients with Borrmann type IV gastric carcinoma. Br J Cancer. 1995 Jan;71(1):191–195. doi: 10.1038/bjc.1995.39. [DOI] [PMC free article] [PubMed] [Google Scholar]
  74. Kijima-Suda I., Miyamoto Y., Toyoshima S., Itoh M., Osawa T. Inhibition of experimental pulmonary metastasis of mouse colon adenocarcinoma 26 sublines by a sialic acid:nucleoside conjugate having sialyltransferase inhibiting activity. Cancer Res. 1986 Feb;46(2):858–862. [PubMed] [Google Scholar]
  75. Kijima-Suda I., Miyazawa T., Itoh M., Toyoshima S., Osawa T. Possible mechanism of inhibition of experimental pulmonary metastasis of mouse colon adenocarcinoma 26 sublines by a sialic acid: nucleoside conjugate. Cancer Res. 1988 Jul 1;48(13):3728–3732. [PubMed] [Google Scholar]
  76. Kjeldsen T., Clausen H., Hirohashi S., Ogawa T., Iijima H., Hakomori S. Preparation and characterization of monoclonal antibodies directed to the tumor-associated O-linked sialosyl-2----6 alpha-N-acetylgalactosaminyl (sialosyl-Tn) epitope. Cancer Res. 1988 Apr 15;48(8):2214–2220. [PubMed] [Google Scholar]
  77. Kojima N., Handa K., Newman W., Hakomori S. Inhibition of selectin-dependent tumor cell adhesion to endothelial cells and platelets by blocking O-glycosylation of these cells. Biochem Biophys Res Commun. 1992 Feb 14;182(3):1288–1295. doi: 10.1016/0006-291x(92)91872-n. [DOI] [PubMed] [Google Scholar]
  78. Komminoth P., Roth J., Lackie P. M., Bitter-Suermann D., Heitz P. U. Polysialic acid of the neural cell adhesion molecule distinguishes small cell lung carcinoma from carcinoids. Am J Pathol. 1991 Aug;139(2):297–304. [PMC free article] [PubMed] [Google Scholar]
  79. Komminoth P., Roth J., Saremaslani P., Matias-Guiu X., Wolfe H. J., Heitz P. U. Polysialic acid of the neural cell adhesion molecule in the human thyroid: a marker for medullary thyroid carcinoma and primary C-cell hyperplasia. An immunohistochemical study on 79 thyroid lesions. Am J Surg Pathol. 1994 Apr;18(4):399–411. doi: 10.1097/00000478-199404000-00008. [DOI] [PubMed] [Google Scholar]
  80. Kornfeld R., Kornfeld S. Assembly of asparagine-linked oligosaccharides. Annu Rev Biochem. 1985;54:631–664. doi: 10.1146/annurev.bi.54.070185.003215. [DOI] [PubMed] [Google Scholar]
  81. Laferte S., Dennis J. W. Purification of two glycoproteins expressing beta 1-6 branched Asn-linked oligosaccharides from metastatic tumour cells. Biochem J. 1989 Apr 15;259(2):569–576. doi: 10.1042/bj2590569. [DOI] [PMC free article] [PubMed] [Google Scholar]
  82. Le Marer N., Laudet V., Svensson E. C., Cazlaris H., Van Hille B., Lagrou C., Stehelin D., Montreuil J., Verbert A., Delannoy P. The c-Ha-ras oncogene induces increased expression of beta-galactoside alpha-2, 6-sialyltransferase in rat fibroblast (FR3T3) cells. Glycobiology. 1992 Feb;2(1):49–56. doi: 10.1093/glycob/2.1.49. [DOI] [PubMed] [Google Scholar]
  83. Le Marer N., Stéhelin D. High alpha-2,6-sialylation of N-acetyllactosamine sequences in ras-transformed rat fibroblasts correlates with high invasive potential. Glycobiology. 1995 Mar;5(2):219–226. doi: 10.1093/glycob/5.2.219. [DOI] [PubMed] [Google Scholar]
  84. Leathem A. J., Brooks S. A. Predictive value of lectin binding on breast-cancer recurrence and survival. Lancet. 1987 May 9;1(8541):1054–1056. doi: 10.1016/s0140-6736(87)90482-x. [DOI] [PubMed] [Google Scholar]
  85. Limas C., Lange P. T-antigen in normal and neoplastic urothelium. Cancer. 1986 Sep 15;58(6):1236–1245. doi: 10.1002/1097-0142(19860915)58:6<1236::aid-cncr2820580611>3.0.co;2-i. [DOI] [PubMed] [Google Scholar]
  86. Livingston B. D., Jacobs J. L., Glick M. C., Troy F. A. Extended polysialic acid chains (n greater than 55) in glycoproteins from human neuroblastoma cells. J Biol Chem. 1988 Jul 5;263(19):9443–9448. [PubMed] [Google Scholar]
  87. MacLean G. D., Reddish M., Koganty R. R., Wong T., Gandhi S., Smolenski M., Samuel J., Nabholtz J. M., Longenecker B. M. Immunization of breast cancer patients using a synthetic sialyl-Tn glycoconjugate plus Detox adjuvant. Cancer Immunol Immunother. 1993;36(4):215–222. doi: 10.1007/BF01740902. [DOI] [PMC free article] [PubMed] [Google Scholar]
  88. Magnani J. L., Nilsson B., Brockhaus M., Zopf D., Steplewski Z., Koprowski H., Ginsburg V. A monoclonal antibody-defined antigen associated with gastrointestinal cancer is a ganglioside containing sialylated lacto-N-fucopentaose II. J Biol Chem. 1982 Dec 10;257(23):14365–14369. [PubMed] [Google Scholar]
  89. Mandel U., Langkilde N. C., Orntoft T. F., Therkildsen M. H., Karkov J., Reibel J., White T., Clausen H., Dabelsteen E. Expression of histo-blood-group-A/B-gene-defined glycosyltransferases in normal and malignant epithelia: correlation with A/B-carbohydrate expression. Int J Cancer. 1992 Aug 19;52(1):7–12. doi: 10.1002/ijc.2910520103. [DOI] [PubMed] [Google Scholar]
  90. Matsumoto H., Muramatsu H., Shimotakahara T., Yanagi M., Nishijima H., Mitani N., Baba K., Muramatsu T., Shimazu H. Correlation of expression of ABH blood group carbohydrate antigens with metastatic potential in human lung carcinomas. Cancer. 1993 Jul 1;72(1):75–81. doi: 10.1002/1097-0142(19930701)72:1<75::aid-cncr2820720116>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
  91. Matsusako T., Muramatsu H., Shirahama T., Muramatsu T., Ohi Y. Expression of a carbohydrate signal, sialyl dimeric Le(x) antigen, is associated with metastatic potential of transitional cell carcinoma of the human urinary bladder. Biochem Biophys Res Commun. 1991 Dec 31;181(3):1218–1222. doi: 10.1016/0006-291x(91)92068-u. [DOI] [PubMed] [Google Scholar]
  92. Matsushita Y., Nakamori S., Seftor E. A., Hendrix M. J., Irimura T. Human colon carcinoma cells with increased invasive capacity obtained by selection for sialyl-dimeric LeX antigen. Exp Cell Res. 1991 Sep;196(1):20–25. doi: 10.1016/0014-4827(91)90451-y. [DOI] [PubMed] [Google Scholar]
  93. Miles D. W., Happerfield L. C., Smith P., Gillibrand R., Bobrow L. G., Gregory W. M., Rubens R. D. Expression of sialyl-Tn predicts the effect of adjuvant chemotherapy in node-positive breast cancer. Br J Cancer. 1994 Dec;70(6):1272–1275. doi: 10.1038/bjc.1994.486. [DOI] [PMC free article] [PubMed] [Google Scholar]
  94. Mizoguchi A., Takasaki S., Maeda S., Kobata A. Changes in asparagine-linked sugar chains of human promyelocytic leukemic cells (HL-60) during monocytoid differentiation and myeloid differentiation. Decrease of high-molecular-weight oligosaccharides in acidic fraction. J Biol Chem. 1984 Oct 10;259(19):11949–11957. [PubMed] [Google Scholar]
  95. Moolenaar C. E., Muller E. J., Schol D. J., Figdor C. G., Bock E., Bitter-Suermann D., Michalides R. J. Expression of neural cell adhesion molecule-related sialoglycoprotein in small cell lung cancer and neuroblastoma cell lines H69 and CHP-212. Cancer Res. 1990 Feb 15;50(4):1102–1106. [PubMed] [Google Scholar]
  96. Morgenthaler J., Kemmner W., Brossmer R. Sialic acid dependent cell adhesion to collagen IV correlates with in vivo tumorigenicity of the human colon carcinoma sublines HCT116, HCT116a and HCT116b. Biochem Biophys Res Commun. 1990 Sep 14;171(2):860–866. doi: 10.1016/0006-291x(90)91225-h. [DOI] [PubMed] [Google Scholar]
  97. Nakasaki H., Mitomi T., Noto T., Ogoshi K., Hanaue H., Tanaka Y., Makuuchi H., Clausen H., Hakomori S. Mosaicism in the expression of tumor-associated carbohydrate antigens in human colonic and gastric cancers. Cancer Res. 1989 Jul 1;49(13):3662–3669. [PubMed] [Google Scholar]
  98. Newton S. A., White S. L., Humphries M. J., Olden K. Swainsonine inhibition of spontaneous metastasis. J Natl Cancer Inst. 1989 Jul 5;81(13):1024–1028. doi: 10.1093/jnci/81.13.1024. [DOI] [PubMed] [Google Scholar]
  99. Nilsson O., Lindholm L., Holmgren J., Svennerholm L. Monoclonal antibodies raised against NeuAc alpha 2-6neolactotetraosylceramide detect carcinoma-associated gangliosides. Biochim Biophys Acta. 1985 Jul 31;835(3):577–583. doi: 10.1016/0005-2760(85)90127-4. [DOI] [PubMed] [Google Scholar]
  100. Nishiyama T., Matsumoto Y., Watanabe H., Fujiwara M., Sato S. Detection of Tn antigen with Vicia villosa agglutinin in urinary bladder cancer: its relevance to the patient's clinical course. J Natl Cancer Inst. 1987 Jun;78(6):1113–1118. [PubMed] [Google Scholar]
  101. O'Boyle K. P., Zamore R., Adluri S., Cohen A., Kemeny N., Welt S., Lloyd K. O., Oettgen H. F., Old L. J., Livingston P. O. Immunization of colorectal cancer patients with modified ovine submaxillary gland mucin and adjuvants induces IgM and IgG antibodies to sialylated Tn. Cancer Res. 1992 Oct 15;52(20):5663–5667. [PubMed] [Google Scholar]
  102. Ogata S., Ho I., Chen A., Dubois D., Maklansky J., Singhal A., Hakomori S., Itzkowitz S. H. Tumor-associated sialylated antigens are constitutively expressed in normal human colonic mucosa. Cancer Res. 1995 May 1;55(9):1869–1874. [PubMed] [Google Scholar]
  103. Ogata S., Maimonis P. J., Itzkowitz S. H. Mucins bearing the cancer-associated sialosyl-Tn antigen mediate inhibition of natural killer cell cytotoxicity. Cancer Res. 1992 Sep 1;52(17):4741–4746. [PubMed] [Google Scholar]
  104. Ogawa J., Sano A., Inoue H., Koide S. Expression of Lewis-related antigen and prognosis in stage I non-small cell lung cancer. Ann Thorac Surg. 1995 Feb;59(2):412–415. doi: 10.1016/0003-4975(94)00866-6. [DOI] [PubMed] [Google Scholar]
  105. Ogawa J., Tsurumi T., Yamada S., Koide S., Shohtsu A. Blood vessel invasion and expression of sialyl Lewisx and proliferating cell nuclear antigen in stage I non-small cell lung cancer. Relation to postoperative recurrence. Cancer. 1994 Feb 15;73(4):1177–1183. doi: 10.1002/1097-0142(19940215)73:4<1177::aid-cncr2820730409>3.0.co;2-0. [DOI] [PubMed] [Google Scholar]
  106. Okada Y., Arima T., Togawa K., Nagashima H., Jinno K., Moriwaki S., Kunitomo T., Thurin J., Koprowski H. Neoexpression of ABH and Lewis blood group antigens in human hepatocellular carcinomas. J Natl Cancer Inst. 1987 Jan;78(1):19–28. doi: 10.1093/jnci/78.1.19. [DOI] [PubMed] [Google Scholar]
  107. Orntoft T. F. Carbohydrate changes in bladder carcinomas. APMIS Suppl. 1992;27:181–187. [PubMed] [Google Scholar]
  108. Orntoft T. F., Harving N., Langkilde N. C. O-linked mucin-type glycoproteins in normal and malignant colon mucosa: lack of T-antigen expression and accumulation of Tn and sialosyl-Tn antigens in carcinomas. Int J Cancer. 1990 Apr 15;45(4):666–672. doi: 10.1002/ijc.2910450416. [DOI] [PubMed] [Google Scholar]
  109. Orntoft T. F., Wolf H., Clausen H., Dabelsteen E., Hakomori S. Blood group ABH-related antigens in normal and malignant bladder urothelium: possible structural basis for the deletion of type-2 chain ABH antigens in invasive carcinomas. Int J Cancer. 1989 May 15;43(5):774–780. doi: 10.1002/ijc.2910430505. [DOI] [PubMed] [Google Scholar]
  110. Osako M., Yonezawa S., Siddiki B., Huang J., Ho J. J., Kim Y. S., Sato E. Immunohistochemical study of mucin carbohydrates and core proteins in human pancreatic tumors. Cancer. 1993 Apr 1;71(7):2191–2199. doi: 10.1002/1097-0142(19930401)71:7<2191::aid-cncr2820710705>3.0.co;2-x. [DOI] [PubMed] [Google Scholar]
  111. Passaniti A., Hart G. W. Cell surface sialylation and tumor metastasis. Metastatic potential of B16 melanoma variants correlates with their relative numbers of specific penultimate oligosaccharide structures. J Biol Chem. 1988 Jun 5;263(16):7591–7603. [PubMed] [Google Scholar]
  112. Penno M. B., Passaniti A., Fridman R., Hart G. W., Jordan C., Kumar S., Scott A. F. In vitro galactosylation of a 110-kDa glycoprotein by an endogenous cell surface galactosyltransferase correlates with the invasiveness of adrenal carcinoma cells. Proc Natl Acad Sci U S A. 1989 Aug;86(16):6057–6061. doi: 10.1073/pnas.86.16.6057. [DOI] [PMC free article] [PubMed] [Google Scholar]
  113. Phillips M. L., Nudelman E., Gaeta F. C., Perez M., Singhal A. K., Hakomori S., Paulson J. C. ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex. Science. 1990 Nov 23;250(4984):1130–1132. doi: 10.1126/science.1701274. [DOI] [PubMed] [Google Scholar]
  114. Pierce M., Arango J. Rous sarcoma virus-transformed baby hamster kidney cells express higher levels of asparagine-linked tri- and tetraantennary glycopeptides containing [GlcNAc-beta (1,6)Man-alpha (1,6)Man] and poly-N-acetyllactosamine sequences than baby hamster kidney cells. J Biol Chem. 1986 Aug 15;261(23):10772–10777. [PubMed] [Google Scholar]
  115. Piller F., Cartron J. P., Maranduba A., Veyrières A., Leroy Y., Fournet B. Biosynthesis of blood group I antigens. Identification of a UDP-GlcNAc:GlcNAc beta 1-3Gal(-R) beta 1-6(GlcNAc to Gal) N-acetylglucosaminyltransferase in hog gastric mucosa. J Biol Chem. 1984 Nov 10;259(21):13385–13390. [PubMed] [Google Scholar]
  116. Piscatelli J. J., Cohen S. A., Berenson C. S., Lance P. Determinants of differential liver-colonizing potential of variants of the MCA-38 murine colon cancer cell line. Clin Exp Metastasis. 1995 Mar;13(2):141–150. doi: 10.1007/BF00133619. [DOI] [PubMed] [Google Scholar]
  117. Pulverer G., Beuth J., Ko H. L., Yassin A., Ohshima Y., Roszkowski K., Uhlenbruck G. Glycoprotein modifications of sarcoma L-1 tumor cells by tunicamycin, swainsonine, bromoconduritol or 1-desoxynojirimycin treatment inhibits their metastatic lung colonization in Balb/c-mice. J Cancer Res Clin Oncol. 1988;114(2):217–220. doi: 10.1007/BF00417842. [DOI] [PubMed] [Google Scholar]
  118. Roth J., Zuber C., Wagner P., Taatjes D. J., Weisgerber C., Heitz P. U., Goridis C., Bitter-Suermann D. Reexpression of poly(sialic acid) units of the neural cell adhesion molecule in Wilms tumor. Proc Natl Acad Sci U S A. 1988 May;85(9):2999–3003. doi: 10.1073/pnas.85.9.2999. [DOI] [PMC free article] [PubMed] [Google Scholar]
  119. Rutishauser U., Acheson A., Hall A. K., Mann D. M., Sunshine J. The neural cell adhesion molecule (NCAM) as a regulator of cell-cell interactions. Science. 1988 Apr 1;240(4848):53–57. doi: 10.1126/science.3281256. [DOI] [PubMed] [Google Scholar]
  120. Saitoh O., Piller F., Fox R. I., Fukuda M. T-lymphocytic leukemia expresses complex, branched O-linked oligosaccharides on a major sialoglycoprotein, leukosialin. Blood. 1991 Apr 1;77(7):1491–1499. [PubMed] [Google Scholar]
  121. Sakamoto S., Watanabe T., Tokumaru T., Takagi H., Nakazato H., Lloyd K. O. Expression of Lewisa, Lewisb, Lewisx, Lewisy, siayl-Lewisa, and sialyl-Lewisx blood group antigens in human gastric carcinoma and in normal gastric tissue. Cancer Res. 1989 Feb 1;49(3):745–752. [PubMed] [Google Scholar]
  122. Santer U. V., Gilbert F., Glick M. C. Change in glycosylation of membrane glycoproteins after transfection of NIH 3T3 with human tumor DNA. Cancer Res. 1984 Sep;44(9):3730–3735. [PubMed] [Google Scholar]
  123. Sata T., Roth J., Zuber C., Stamm B., Heitz P. U. Expression of alpha 2,6-linked sialic acid residues in neoplastic but not in normal human colonic mucosa. A lectin-gold cytochemical study with Sambucus nigra and Maackia amurensis lectins. Am J Pathol. 1991 Dec;139(6):1435–1448. [PMC free article] [PubMed] [Google Scholar]
  124. Scheidegger E. P., Lackie P. M., Papay J., Roth J. In vitro and in vivo growth of clonal sublines of human small cell lung carcinoma is modulated by polysialic acid of the neural cell adhesion molecule. Lab Invest. 1994 Jan;70(1):95–106. [PubMed] [Google Scholar]
  125. Schuessler M. H., Pintado S., Welt S., Real F. X., Xu M., Melamed M. R., Lloyd K. O., Oettgen H. F. Blood group and blood-group-related antigens in normal pancreas and pancreas cancer: enhanced expression of precursor type 1, Tn and sialyl-Tn in pancreas cancer. Int J Cancer. 1991 Jan 21;47(2):180–187. doi: 10.1002/ijc.2910470204. [DOI] [PubMed] [Google Scholar]
  126. Siddiki B., Ho J. J., Huang J., Byrd J. C., Lau E., Yuan M., Kim Y. S. Monoclonal antibody directed against colon cancer mucin has high specificity for malignancy. Int J Cancer. 1993 May 28;54(3):467–474. doi: 10.1002/ijc.2910540319. [DOI] [PubMed] [Google Scholar]
  127. Singhal A. K., Orntoft T. F., Nudelman E., Nance S., Schibig L., Stroud M. R., Clausen H., Hakomori S. Profiles of Lewisx-containing glycoproteins and glycolipids in sera of patients with adenocarcinoma. Cancer Res. 1990 Mar 1;50(5):1375–1380. [PubMed] [Google Scholar]
  128. Singhal A., Fohn M., Hakomori S. Induction of alpha-N-acetylgalactosamine-O-serine/threonine (Tn) antigen-mediated cellular immune response for active immunotherapy in mice. Cancer Res. 1991 Mar 1;51(5):1406–1411. [PubMed] [Google Scholar]
  129. Springer G. F. Tn epitope (N-acetyl-D-galactosamine alpha-O-serine/threonine) density in primary breast carcinoma: a functional predictor of aggressiveness. Mol Immunol. 1989 Jan;26(1):1–5. doi: 10.1016/0161-5890(89)90013-8. [DOI] [PubMed] [Google Scholar]
  130. Stenersen T. C., Dabelsteen E. Changes in the glycosylation pattern of histo-blood group antigens in benign, premalignant and malignant laryngeal epithelial lesions. APMIS Suppl. 1992;27:139–148. [PubMed] [Google Scholar]
  131. Summers J. L., Coon J. S., Ward R. M., Falor W. H., Miller A. W., 3rd, Weinstein R. S. Prognosis in carcinoma of the urinary bladder based upon tissue blood group abh and Thomsen-Friedenreich antigen status and karyotype of the initial tumor. Cancer Res. 1983 Feb;43(2):934–939. [PubMed] [Google Scholar]
  132. Takada A., Ohmori K., Yoneda T., Tsuyuoka K., Hasegawa A., Kiso M., Kannagi R. Contribution of carbohydrate antigens sialyl Lewis A and sialyl Lewis X to adhesion of human cancer cells to vascular endothelium. Cancer Res. 1993 Jan 15;53(2):354–361. [PubMed] [Google Scholar]
  133. Takano R., Muchmore E., Dennis J. W. Sialylation and malignant potential in tumour cell glycosylation mutants. Glycobiology. 1994 Oct;4(5):665–674. doi: 10.1093/glycob/4.5.665. [DOI] [PubMed] [Google Scholar]
  134. Takano R., Nose M., Nishihira T., Kyogoku M. Increase of beta 1-6-branched oligosaccharides in human esophageal carcinomas invasive against surrounding tissue in vivo and in vitro. Am J Pathol. 1990 Nov;137(5):1007–1011. [PMC free article] [PubMed] [Google Scholar]
  135. Tao T. W., Burger M. M. Non-metastasising variants selected from metastasising melanoma cells. Nature. 1977 Dec 1;270(5636):437–438. doi: 10.1038/270437a0. [DOI] [PubMed] [Google Scholar]
  136. Tözeren A., Kleinman H. K., Grant D. S., Morales D., Mercurio A. M., Byers S. W. E-selectin-mediated dynamic interactions of breast- and colon-cancer cells with endothelial-cell monolayers. Int J Cancer. 1995 Jan 27;60(3):426–431. doi: 10.1002/ijc.2910600326. [DOI] [PubMed] [Google Scholar]
  137. Vavasseur F., Dole K., Yang J., Matta K. L., Myerscough N., Corfield A., Paraskeva C., Brockhausen I. O-glycan biosynthesis in human colorectal adenoma cells during progression to cancer. Eur J Biochem. 1994 Jun 1;222(2):415–424. doi: 10.1111/j.1432-1033.1994.tb18880.x. [DOI] [PubMed] [Google Scholar]
  138. Vavasseur F., Yang J. M., Dole K., Paulsen H., Brockhausen I. Synthesis of O-glycan core 3: characterization of UDP-GlcNAc: GalNAc-R beta 3-N-acetyl-glucosaminyltransferase activity from colonic mucosal tissues and lack of the activity in human cancer cell lines. Glycobiology. 1995 May;5(3):351–357. doi: 10.1093/glycob/5.3.351. [DOI] [PubMed] [Google Scholar]
  139. Vertino-Bell A., Ren J., Black J. D., Lau J. T. Developmental regulation of beta-galactoside alpha 2,6-sialyltransferase in small intestine epithelium. Dev Biol. 1994 Sep;165(1):126–136. doi: 10.1006/dbio.1994.1240. [DOI] [PubMed] [Google Scholar]
  140. Wagner H. E., Thomas P., Wolf B. C., Rapoza A., Steele G., Jr Inhibition of sialic acid incorporation prevents hepatic metastases. Arch Surg. 1990 Mar;125(3):351–354. doi: 10.1001/archsurg.1990.01410150073013. [DOI] [PubMed] [Google Scholar]
  141. Walz G., Aruffo A., Kolanus W., Bevilacqua M., Seed B. Recognition by ELAM-1 of the sialyl-Lex determinant on myeloid and tumor cells. Science. 1990 Nov 23;250(4984):1132–1135. doi: 10.1126/science.1701275. [DOI] [PubMed] [Google Scholar]
  142. Warren L., Buck C. A., Tuszynski G. P. Glycopeptide changes and malignant transformation. A possible role for carbohydrate in malignant behavior. Biochim Biophys Acta. 1978 Sep 18;516(1):97–127. doi: 10.1016/0304-419x(78)90005-7. [DOI] [PubMed] [Google Scholar]
  143. Watkins W. M. Biochemistry and Genetics of the ABO, Lewis, and P blood group systems. Adv Hum Genet. 1980;10:1-136, 379-85. doi: 10.1007/978-1-4615-8288-5_1. [DOI] [PubMed] [Google Scholar]
  144. Werther J. L., Rivera-MacMurray S., Bruckner H., Tatematsu M., Itzkowitz S. H. Mucin-associated sialosyl-Tn antigen expression in gastric cancer correlates with an adverse outcome. Br J Cancer. 1994 Mar;69(3):613–616. doi: 10.1038/bjc.1994.114. [DOI] [PMC free article] [PubMed] [Google Scholar]
  145. Yagel S., Feinmesser R., Waghorne C., Lala P. K., Breitman M. L., Dennis J. W. Evidence that beta 1-6 branched Asn-linked oligosaccharides on metastatic tumor cells facilitate invasion of basement membranes. Int J Cancer. 1989 Oct 15;44(4):685–690. doi: 10.1002/ijc.2910440422. [DOI] [PubMed] [Google Scholar]
  146. Yamamoto F., Clausen H., White T., Marken J., Hakomori S. Molecular genetic basis of the histo-blood group ABO system. Nature. 1990 May 17;345(6272):229–233. doi: 10.1038/345229a0. [DOI] [PubMed] [Google Scholar]
  147. Yamashita K., Fukushima K., Sakiyama T., Murata F., Kuroki M., Matsuoka Y. Expression of Sia alpha 2-->6Gal beta 1-->4GlcNAc residues on sugar chains of glycoproteins including carcinoembryonic antigens in human colon adenocarcinoma: applications of Trichosanthes japonica agglutinin I for early diagnosis. Cancer Res. 1995 Apr 15;55(8):1675–1679. [PubMed] [Google Scholar]
  148. Yang J. M., Byrd J. C., Siddiki B. B., Chung Y. S., Okuno M., Sowa M., Kim Y. S., Matta K. L., Brockhausen I. Alterations of O-glycan biosynthesis in human colon cancer tissues. Glycobiology. 1994 Dec;4(6):873–884. doi: 10.1093/glycob/4.6.873. [DOI] [PubMed] [Google Scholar]
  149. Yogeeswaran G., Salk P. L. Metastatic potential is positively correlated with cell surface sialylation of cultured murine tumor cell lines. Science. 1981 Jun 26;212(4502):1514–1516. doi: 10.1126/science.7233237. [DOI] [PubMed] [Google Scholar]
  150. Youakim A., Romero P. A., Yee K., Carlsson S. R., Fukuda M., Herscovics A. Decrease in polylactosaminoglycans associated with lysosomal membrane glycoproteins during differentiation of CaCo-2 human colonic adenocarcinoma cells. Cancer Res. 1989 Dec 15;49(24 Pt 1):6889–6895. [PubMed] [Google Scholar]
  151. Yousefi S., Higgins E., Daoling Z., Pollex-Krüger A., Hindsgaul O., Dennis J. W. Increased UDP-GlcNAc:Gal beta 1-3GaLNAc-R (GlcNAc to GaLNAc) beta-1, 6-N-acetylglucosaminyltransferase activity in metastatic murine tumor cell lines. Control of polylactosamine synthesis. J Biol Chem. 1991 Jan 25;266(3):1772–1782. [PubMed] [Google Scholar]
  152. Yuan M., Itzkowitz S. H., Boland C. R., Kim Y. D., Tomita J. T., Palekar A., Bennington J. L., Trump B. F., Kim Y. S. Comparison of T-antigen expression in normal, premalignant, and malignant human colonic tissue using lectin and antibody immunohistochemistry. Cancer Res. 1986 Sep;46(9):4841–4847. [PubMed] [Google Scholar]
  153. Yuan M., Itzkowitz S. H., Palekar A., Shamsuddin A. M., Phelps P. C., Trump B. F., Kim Y. S. Distribution of blood group antigens A, B, H, Lewisa, and Lewisb in human normal, fetal, and malignant colonic tissue. Cancer Res. 1985 Sep;45(9):4499–4511. [PubMed] [Google Scholar]
  154. van den Eijnden D. H., Koenderman A. H., Schiphorst W. E. Biosynthesis of blood group i-active polylactosaminoglycans. Partial purification and properties of an UDP-GlcNAc:N-acetyllactosaminide beta 1----3-N-acetylglucosaminyltransferase from Novikoff tumor cell ascites fluid. J Biol Chem. 1988 Sep 5;263(25):12461–12471. [PubMed] [Google Scholar]

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