Abstract
The plasma iron turnover was measured in 19 normal subjects. A correlation was found between plasma iron concentration and plasma iron turnover. In addition to the turnover of 55Fe at normal plasma iron concentration (predominantly monoferric transferrin), a second turnover in which the labeled plasma was saturated with iron (to produce predominantly diferric transferrin) was studied with 50Fe. It was demonstrated that diferric transferrin had a greater rate of iron turnover but that the distribution between erythroid and non-erythroid tissues was unchanged. It was concluded that plasma iron turnover is dependent on the monoferric/diferric transferrin ratio in the plasma but that the internal distribution of iron is unaffected.
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Selected References
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- Aisen P., Brown E. B. The iron-binding function of transferrin in iron metabolism. Semin Hematol. 1977 Jan;14(1):31–53. [PubMed] [Google Scholar]
- BAINTON D. F., FINCH C. A. THE DIAGNOSIS OF IRON DEFICIENCY ANEMIA. Am J Med. 1964 Jul;37:62–70. doi: 10.1016/0002-9343(64)90212-8. [DOI] [PubMed] [Google Scholar]
- Brown E. B., Okada S., Awai M., Chipman B. In vivo evidence for the functional heterogeneity of transferrin-bound iron. III. Studies of transferrin at high and low iron saturation. J Lab Clin Med. 1975 Oct;86(4):576–585. [PubMed] [Google Scholar]
- Cook J. D. An evaluation of adsorption methods for measurement of plasma iron-binding capacity. J Lab Clin Med. 1970 Sep;76(3):497–506. [PubMed] [Google Scholar]
- Cook J. D., Marsaglia G., Eschbach J. W., Funk D. D., Finch C. A. Ferrokinetics: a biologic model for plasma iron exchange in man. J Clin Invest. 1970 Feb;49(2):197–205. doi: 10.1172/JCI106228. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cramer E., Auclair C., Hakim J., Feliu E., Boucherot J., Troube H., Bernard J. F., Bergogne E., Boivin P. Metabolic activity of phagocytosing granulocytes in chronic granulocytic leukemia: ultrastructural observation of a degranulation defect. Blood. 1977 Jul;50(1):93–106. [PubMed] [Google Scholar]
- Eakins J. D., Brown D. A. An improved method for the simultaneous determination of iron-55 and iron-59 in blood by liquid scintillation counting. Int J Appl Radiat Isot. 1966 Jul;17(7):391–397. doi: 10.1016/0020-708x(66)90065-2. [DOI] [PubMed] [Google Scholar]
- Finch C. A., Deubelbeiss K., Cook J. D., Eschbach J. W., Harker L. A., Funk D. D., Marsaglia G., Hillman R. S., Slichter S., Adamson J. W. Ferrokinetics in man. Medicine (Baltimore) 1970 Jan;49(1):17–53. doi: 10.1097/00005792-197001000-00002. [DOI] [PubMed] [Google Scholar]
- Fletcher J., Huehns E. R. Significance of the binding of iron by transferrin. Nature. 1967 Aug 5;215(5101):584–586. doi: 10.1038/215584a0. [DOI] [PubMed] [Google Scholar]
- Fletcher J. The plasma clearance and liver uptake of iron from transferrin of low and high iron saturation. Clin Sci. 1971 Nov;41(5):395–402. doi: 10.1042/cs0410395. [DOI] [PubMed] [Google Scholar]
- Hahn D., Baviera B., Ganzoni A. M. Functional heterogeneity of the transport iron compartment I. In vivo radioiron clearance from high and low saturated transferrin. Acta Haematol. 1975;53(5):285–291. doi: 10.1159/000208194. [DOI] [PubMed] [Google Scholar]
- Hosain F., Marsaglia G., Finch C. A. Blood ferrokinetics in normal man. J Clin Invest. 1967 Jan;46(1):1–9. doi: 10.1172/JCI105501. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Miles L. E., Lipschitz D. A., Bieber C. P., Cook J. D. Measurement of serum ferritin by a 2-site immunoradiometric assay. Anal Biochem. 1974 Sep;61(1):209–224. doi: 10.1016/0003-2697(74)90347-9. [DOI] [PubMed] [Google Scholar]
- Pootrakul P., Christensen A., Josephson B., Finch C. A. Role of transferrin in determining internal iron distribution. Blood. 1977 Jun;49(6):957–966. [PubMed] [Google Scholar]