Skip to main content
Bacteriological Reviews logoLink to Bacteriological Reviews
. 1973 Jun;37(2):197–214. doi: 10.1128/br.37.2.197-214.1973

Use of somatic cell hybrids for analysis of the differentiated state.

F M Davis, E A Adelberg
PMCID: PMC413811  PMID: 4581783

Full text

PDF
198

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barski G. Cell association and somatic cell hybridization. Int Rev Exp Pathol. 1970;9:151–190. [PubMed] [Google Scholar]
  2. Benda P., Davidson R. L. Regulation of specific functions of glial cells in somatic hybrids. I. Control of S100 protein. J Cell Physiol. 1971 Oct;78(2):209–216. doi: 10.1002/jcp.1040780207. [DOI] [PubMed] [Google Scholar]
  3. Benedict W. F., Nebert D. W., Thompson E. B. Expression of aryl hydrocarbon hydroxylase induction and suppression of tyrosine aminotransferase induction in somatic-cell hybrids. Proc Natl Acad Sci U S A. 1972 Aug;69(8):2179–2183. doi: 10.1073/pnas.69.8.2179. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bertolotti R., Weiss M. C. Expression of differentiated functions in hepatoma cell hybrids. II. Aldolase. J Cell Physiol. 1972 Apr;79(2):211–224. doi: 10.1002/jcp.1040790206. [DOI] [PubMed] [Google Scholar]
  5. Bertolotti R., Weiss M. C. Expression of differentiated functions in hepatoma cell hybrids. VI. Extinction and re-expression of liver alcohol dehydrogenase. Biochimie. 1972;54(2):195–201. doi: 10.1016/s0300-9084(72)80104-4. [DOI] [PubMed] [Google Scholar]
  6. Bolund L., Ringertz N. R., Harris H. Changes in the cytochemical properties of erythrocyte nuclei reactivated by cell fusion. J Cell Sci. 1969 Jan;4(1):71–87. doi: 10.1242/jcs.4.1.71. [DOI] [PubMed] [Google Scholar]
  7. Bramwell M. E., Handmaker S. D. Ribosomal RNA synthesis in human-mouse hybrid cells. Biochim Biophys Acta. 1971 Mar 25;232(3):580–583. doi: 10.1016/0005-2787(71)90611-3. [DOI] [PubMed] [Google Scholar]
  8. Britten R. J., Davidson E. H. Gene regulation for higher cells: a theory. Science. 1969 Jul 25;165(3891):349–357. doi: 10.1126/science.165.3891.349. [DOI] [PubMed] [Google Scholar]
  9. Carlsson S. A., Moore G. P., Ringertz N. R. Nucleo-cytoplasmic protein migration during the activation of chick erythrocyte nuclei in heterokaryons. Exp Cell Res. 1973 Jan;76(1):234–241. doi: 10.1016/0014-4827(73)90441-2. [DOI] [PubMed] [Google Scholar]
  10. Coffino P., Knowles B., Nathenson S. G., Scharff M. D. Suppression of immunoglobulin synthesis by cellular hybridization. Nat New Biol. 1971 May 19;231(20):87–90. doi: 10.1038/newbio231087a0. [DOI] [PubMed] [Google Scholar]
  11. Colten H. R. In vitro synthesis of a regulator of mammalian gene expression. Proc Natl Acad Sci U S A. 1972 Aug;69(8):2233–2236. doi: 10.1073/pnas.69.8.2233. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Colten H. R., Parkman R. Biosynthesis of C4 (fourth component of complement) by hybrids of C4-deficient guinea pig cells and HeLa cells. Science. 1972 Jun 2;176(4038):1029–1031. doi: 10.1126/science.176.4038.1029. [DOI] [PubMed] [Google Scholar]
  13. Davidson R. L., Benda P. Regulation of specific functions of glial cells in somatic hybrids. II. Control of inducibility of glycerol-3-phosphate dehydrogenase. Proc Natl Acad Sci U S A. 1970 Dec;67(4):1870–1877. doi: 10.1073/pnas.67.4.1870. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Davidson R. L., Ephrussi B., Yamamoto K. Regulation of pigment synthesis in mammalian cells, as studied by somatic hybridization. Proc Natl Acad Sci U S A. 1966 Nov;56(5):1437–1440. doi: 10.1073/pnas.56.5.1437. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Davidson R. L. Regulation of gene expression in somatic cell hybrids: a review. In Vitro. 1971 May-Jun;6(6):411–426. doi: 10.1007/BF02616043. [DOI] [PubMed] [Google Scholar]
  16. Davidson R. L. Regulation of malanin synthesis in mammalian cells: effect of gene dosage on the expression of differentiation. Proc Natl Acad Sci U S A. 1972 Apr;69(4):951–955. doi: 10.1073/pnas.69.4.951. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Davidson R., Ephrussi B., Yamamoto K. Regulation of melanin synthesis in mammalian cells, as studied by somatic hybridization. I. Evidence for negative control. J Cell Physiol. 1968 Oct;72(2):115–127. doi: 10.1002/jcp.1040720206. [DOI] [PubMed] [Google Scholar]
  18. Davidson R. Regulation of melanin synthesis in mammalian cells, as studied by somatic hybridization. 3. A method of increasing the frequency of cell fusion. Exp Cell Res. 1969 Jun;55(3):424–426. doi: 10.1016/0014-4827(69)90580-1. [DOI] [PubMed] [Google Scholar]
  19. Davidson R., Yamamoto K. Regulation of melanin synthesis in mammalian cells, as studied by somatic hybridization. II. The level of regulation of 3,4-dihydroxyphenylalanine oxidase. Proc Natl Acad Sci U S A. 1968 Jul;60(3):894–901. doi: 10.1073/pnas.60.3.894. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. DiZerega G., Morrow J. The effect of nerve growth factor on dispersed neuronal hela heterokaryons. Exp Neurol. 1970 Aug;28(2):206–212. doi: 10.1016/0014-4886(70)90230-x. [DOI] [PubMed] [Google Scholar]
  21. Ege T., Carlsson S. A., Ringertz N. R. Immune microfluorimetric analysis of the distribution of species specific nuclear antigens in HeLa-chick erythrocyte heterokaryons. Exp Cell Res. 1971 Dec;69(2):472–477. doi: 10.1016/0014-4827(71)90259-x. [DOI] [PubMed] [Google Scholar]
  22. Eliceiri G. L. The ribosomal RNA of hamster-mouse hybrid cells. J Cell Biol. 1972 Apr;53(1):177–184. doi: 10.1083/jcb.53.1.177. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Finch B. W., Ephrussi B. RETENTION OF MULTIPLE DEVELOPMENTAL POTENTIALITIES BY CELLS OF A MOUSE TESTICULAR TERATOCARCINOMA DURING PROLONGED CULTURE in vitro AND THEIR EXTINCTION UPON HYBRIDIZATION WITH CELLS OF PERMANENT LINES. Proc Natl Acad Sci U S A. 1967 Mar;57(3):615–621. doi: 10.1073/pnas.57.3.615. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Fougère C., Ruiz F., Ephrussi B. Gene dosage dependence of pigment synthesis in melanoma x fibroblast hybrids (hamster cells-mouse fibroblast-DOPA-oxidase-irradiation). Proc Natl Acad Sci U S A. 1972 Feb;69(2):330–334. doi: 10.1073/pnas.69.2.330. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Ganschow R. Glucuronidase gene expression in somatic hybrids. Science. 1966 Jul 1;153(3731):84–85. doi: 10.1126/science.153.3731.84. [DOI] [PubMed] [Google Scholar]
  26. Gelehrter T. D., Emanuel J. R., Spencer C. J. Induction of tyrosine aminotransferase by dexamethasone, insulin, and serum. Characterization of the induced enzyme. J Biol Chem. 1972 Oct 10;247(19):6197–6203. [PubMed] [Google Scholar]
  27. Gordon S., Cohn Z. Macrophage-melanocyte heterokaryons. I. Preparation and properties. J Exp Med. 1970 May 1;131(5):981–1003. doi: 10.1084/jem.131.5.981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Gordon S., Cohn Z. Macrophage-melanocyte heterokaryons. II. The activation of macrophage DNA synthesis. Studies with inhibitors of RNA synthesis. J Exp Med. 1971 Feb 1;133(2):321–338. doi: 10.1084/jem.133.2.321. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Gordon S., Cohn Z. Macrophage-melanoma cell heterokaryons. 3. The activation of macrophage DNA synthesis. Studies with inhibitors of protein synthesis and with synchronized melanoma cells. J Exp Med. 1971 Oct 1;134(4):935–946. doi: 10.1084/jem.134.4.935. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Gordon S., Cohn Z. Macrophage-melanoma cell heterokaryons. IV. Unmasking the macrophage-specific membrane receptor. J Exp Med. 1971 Oct 1;134(4):947–962. doi: 10.1084/jem.134.4.947. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Green H., Ephrussi B., Yoshida M., Hamerman D. Synthesis of collagen and hyaluronic acid by fibroblast hybrids. Proc Natl Acad Sci U S A. 1966 Jan;55(1):41–44. doi: 10.1073/pnas.55.1.41. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Harris H., Watkins J. F., Ford C. E., Schoefl G. I. Artificial heterokaryons of animal cells from different species. J Cell Sci. 1966 Mar;1(1):1–30. doi: 10.1242/jcs.1.1.1. [DOI] [PubMed] [Google Scholar]
  33. Jacobson C. O. Reactivation of DNA synthesis in mammalian neuron nuclei after fusion with cells of an undifferentiated fibroblast line. Exp Cell Res. 1968 Oct;53(1):316–318. doi: 10.1016/0014-4827(68)90385-6. [DOI] [PubMed] [Google Scholar]
  34. Jami J., Failly C., Ritz E. Lack of expression of differentiation in mouse teratoma-fibroblast somatic cell hybrids. Exp Cell Res. 1973 Jan;76(1):191–199. doi: 10.1016/0014-4827(73)90435-7. [DOI] [PubMed] [Google Scholar]
  35. Kao F. T., Puck T. T. Genetics of somatic mammalian cells: demonstration of a human esterase activator gene linked to the adeB gene. Proc Natl Acad Sci U S A. 1972 Nov;69(11):3273–3277. doi: 10.1073/pnas.69.11.3273. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Klebe R. J., Chen T., Ruddle R. H. Mapping of a human genetic regulator element by somatic cell genetic analysis. Proc Natl Acad Sci U S A. 1970 Aug;66(4):1220–1227. doi: 10.1073/pnas.66.4.1220. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Littlefield J. W. Hybridization of hamster cells with high and low folate reductase activity. Proc Natl Acad Sci U S A. 1969 Jan;62(1):88–95. doi: 10.1073/pnas.62.1.88. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. Migeon B. R., Smith S. W., Leddy C. L. The nature of thymidine kinase in the human-mouse hybrid cell. Biochem Genet. 1969 Dec;3(6):583–590. doi: 10.1007/BF00485479. [DOI] [PubMed] [Google Scholar]
  39. Minna J., Glazer D., Nirenberg M. Genetic dissection of neural properties using somatic cell hybrids. Nat New Biol. 1972 Feb 23;235(60):225–231. doi: 10.1038/newbio235225a0. [DOI] [PubMed] [Google Scholar]
  40. Minna J., Nelson P., Peacock J., Glazer D., Nirenberg M. Genes for neuronal properties expressed in neuroblastoma x L cell hybrids. Proc Natl Acad Sci U S A. 1971 Jan;68(1):234–239. doi: 10.1073/pnas.68.1.234. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. Mohit B., Fan K. Hybrid cell line from a cloned immunoglobulin-producing mouse myeloma and a nonproducing mouse lymphoma. Science. 1971 Jan 8;171(3966):75–77. doi: 10.1126/science.171.3966.75. [DOI] [PubMed] [Google Scholar]
  42. Moore G. P., Ringertz N. R. Localization of DNA-dependent RNA polymerase activities in fixed human fibroblasts by autoradiography. Exp Cell Res. 1973 Jan;76(1):223–228. doi: 10.1016/0014-4827(73)90439-4. [DOI] [PubMed] [Google Scholar]
  43. Periman P. IgG synthesis in hybrid cells from an antibody-producing mouse myeloma and an L cell substrain. Nature. 1970 Dec 12;228(5276):1086–1087. doi: 10.1038/2281086a0. [DOI] [PubMed] [Google Scholar]
  44. Peterson J. A., Weiss M. C. Expression of differentiated functions in hepatoma cell hybrids: induction of mouse albumin production in rat hepatoma-mouse fibroblast hybrids. Proc Natl Acad Sci U S A. 1972 Mar;69(3):571–575. doi: 10.1073/pnas.69.3.571. [DOI] [PMC free article] [PubMed] [Google Scholar]
  45. Ringertz N. R., Carlsson S. A., Ege T., Bolund L. Detection of human and chick nuclear antigens in nuclei of chick erythrocytes during reactivation in heterokaryons with HeLa cells. Proc Natl Acad Sci U S A. 1971 Dec;68(12):3228–3232. doi: 10.1073/pnas.68.12.3228. [DOI] [PMC free article] [PubMed] [Google Scholar]
  46. Rosenberg M. Fusion of frog and tadpole erythrocytes. Nature. 1972 Oct 27;239(5374):520–522. doi: 10.1038/239520b0. [DOI] [PubMed] [Google Scholar]
  47. Ryter A., Benda P. Etude au microscope électronique d'hybrides de cellules gliales et de fibroblasts. Exp Cell Res. 1972 Oct;74(2):407–416. doi: 10.1016/0014-4827(72)90395-3. [DOI] [PubMed] [Google Scholar]
  48. SPENCER R. A., HAUSCHKA T. S., AMOS D. B., EPHRUSSI B. CO-DOMINANCE OF ISOANTIGENS IN SOMATIC HYBRIDS OF MURINE CELLS GROWN IN VITRO. J Natl Cancer Inst. 1964 Nov;33:893–903. doi: 10.1093/jnci/33.5.893. [DOI] [PubMed] [Google Scholar]
  49. Schneider J. A., Weiss M. C. Expression of differentiated functions in hepatoma cell hybrids. I. Tyrosine aminotransferase in hepatoma-fibroblast hybrids. Proc Natl Acad Sci U S A. 1971 Jan;68(1):127–131. doi: 10.1073/pnas.68.1.127. [DOI] [PMC free article] [PubMed] [Google Scholar]
  50. Silagi S. Hybridization of a malignant melanoma cell line with L cells in vitro. Cancer Res. 1967 Nov;27(11):1953–1960. [PubMed] [Google Scholar]
  51. Sonnenschein C., Richardson U. I., Tashjian A. H., Jr Loss of growth hormone production following hybridization of a functional rat pituitary cell strain with a mouse fibroblast line. Exp Cell Res. 1971 Dec;69(2):336–344. doi: 10.1016/0014-4827(71)90233-3. [DOI] [PubMed] [Google Scholar]
  52. Thompson E. B., Gelehrter T. D. Expression of tyrosine aminotransferase activity in somatic-cell heterokaryons: evidence for negative control of enzyme expression. Proc Natl Acad Sci U S A. 1971 Oct;68(10):2589–2593. doi: 10.1073/pnas.68.10.2589. [DOI] [PMC free article] [PubMed] [Google Scholar]
  53. Tomkins G. M., Gelehrter T. D., Granner D., Martin D., Jr, Samuels H. H., Thompson E. B. Control of specific gene expression in higher organisms. Expression of mammalian genes may be controlled by repressors acting on the translation of messenger RNA. Science. 1969 Dec 19;166(3912):1474–1480. doi: 10.1126/science.166.3912.1474. [DOI] [PubMed] [Google Scholar]
  54. Weiss M. C., Chaplain M. Expression of differentiated functions in hepatoma cell hybrids: reappearance of tyrosine aminotransferase inducibility after the loss of chromosomes. Proc Natl Acad Sci U S A. 1971 Dec;68(12):3026–3030. doi: 10.1073/pnas.68.12.3026. [DOI] [PMC free article] [PubMed] [Google Scholar]
  55. Weiss M. C., Ephrussi B. Studies of Interspecific (Rat x Mouse) Somatic Hybrids. II. Lactate Dehydrogenase and beta-GLUCURONIDASE. Genetics. 1966 Nov;54(5):1111–1122. doi: 10.1093/genetics/54.5.1111. [DOI] [PMC free article] [PubMed] [Google Scholar]
  56. Zubay G., Schwartz D., Beckwith J. Mechanism of activation of catabolite-sensitive genes: a positive control system. Proc Natl Acad Sci U S A. 1970 May;66(1):104–110. doi: 10.1073/pnas.66.1.104. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Bacteriological Reviews are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES