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. 1979 Feb;23(2):549–552. doi: 10.1128/iai.23.2.549-552.1979

Staphylococcus aureus cell surface: capsule as a barrier to bacteriophage adsorption.

B J Wilkinson, K M Holmes
PMCID: PMC414199  PMID: 154475

Abstract

Encapsulated Staphylococcus aureus strains M and Smith diffuse bound phage 84 and 52A much less efficiently than their unencapsulated counterparts, M variant and Smith compact. It is proposed that the capsule acts as a barrier excluding phage from interaction with their receptor (cell wall peptidoglycan and teichoic acid). Inefficient phage adsorption by encapsulated staphylococci may explain, in part, the poor phage typing of such strains.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Chatterjee A. N. Use of bacteriophage-resistant mutants to study the nature of the bacteriophage receptor site of Staphylococcus aureus. J Bacteriol. 1969 May;98(2):519–527. doi: 10.1128/jb.98.2.519-527.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Coyette J., Ghuysen J. M. Structure of the cell wall of Staphylococcus aureus, strain Copenhagen. IX. Teichoic acid and phage adsorption. Biochemistry. 1968 Jun;7(6):2385–2389. doi: 10.1021/bi00846a048. [DOI] [PubMed] [Google Scholar]
  3. GAREN A., PUCK T. T. The first two steps of the invasion of host cells by bacterial viruses. II. J Exp Med. 1951 Sep;94(3):177–189. doi: 10.1084/jem.94.3.177. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. HUNT G. A., MOSES A. J. Acute infection of mice with Smith strain of Staphylococcus aureus. Science. 1958 Dec 19;128(3338):1574–1575. doi: 10.1126/science.128.3338.1574. [DOI] [PubMed] [Google Scholar]
  5. Karakawa W. W., Kane J. A. Immunochemical analysis of a galactosamine-rich teichoic acid of Staphylococcus aureus, phage type 187. J Immunol. 1971 Apr;106(4):900–906. [PubMed] [Google Scholar]
  6. Lindberg A. A. Bacteriophage receptors. Annu Rev Microbiol. 1973;27:205–241. doi: 10.1146/annurev.mi.27.100173.001225. [DOI] [PubMed] [Google Scholar]
  7. Melly M. A., Duke L. J., Liau D. F., Hash J. H. Biological properties of the encapsulated Staphylococcus aureus M. Infect Immun. 1974 Aug;10(2):389–397. doi: 10.1128/iai.10.2.389-397.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Park J. T., Shaw D. R., Chatterjee A. N., Mirelman D., Wu T. Mutants of staphylococci with altered cell walls. Ann N Y Acad Sci. 1974 Jul 31;236(0):54–62. doi: 10.1111/j.1749-6632.1974.tb41481.x. [DOI] [PubMed] [Google Scholar]
  9. Peterson P. K., Wilkinson B. J., Kim Y., Schmeling D., Douglas S. D., Quie P. G., Verhoef J. The key role of peptidoglycan in the opsonization of Staphylococcus aureus. J Clin Invest. 1978 Mar;61(3):597–609. doi: 10.1172/JCI108971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Peterson P. K., Wilkinson B. J., Kim Y., Schmeling D., Quie P. G. Influence of encapsulation on staphylococcal opsonization and phagocytosis by human polymorphonuclear leukocytes. Infect Immun. 1978 Mar;19(3):943–949. doi: 10.1128/iai.19.3.943-949.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Scott A. C. A capsulate Staphylococcus aureus. J Med Microbiol. 1969 Aug;2(3):253–260. doi: 10.1099/00222615-2-3-253. [DOI] [PubMed] [Google Scholar]
  12. Smith R. M., Parisi J. T., Vidal L., Baldwin J. N. Nature of the genetic determinant controlling encapsulation in Staphylococcus aureus Smith. Infect Immun. 1977 Jul;17(1):231–234. doi: 10.1128/iai.17.1.231-234.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. WILEY B. B. A new virulence test for Staphylococcus aureus and its application to encapsulated strains. Can J Microbiol. 1961 Dec;7:933–943. doi: 10.1139/m61-118. [DOI] [PubMed] [Google Scholar]
  14. WILKINSON J. F. The extracellualr polysaccharides of bacteria. Bacteriol Rev. 1958 Mar;22(1):46–73. doi: 10.1128/br.22.1.46-73.1958. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Wiley B. B., Maverakis N. H. Capsule production and virulence among strains of Staphylococcus aureus. Ann N Y Acad Sci. 1974 Jul 31;236(0):221–232. doi: 10.1111/j.1749-6632.1974.tb41493.x. [DOI] [PubMed] [Google Scholar]
  16. Wilkinson B. J., Peterson P. K., Quie P. G. Cryptic peptidoglycan and the antiphagocytic effect of the Staphylococcus aureus capsule: model for the antiphagocytic effect of bacterial cell surface polymers. Infect Immun. 1979 Feb;23(2):502–508. doi: 10.1128/iai.23.2.502-508.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Yoshida K., Smith M. R., Naito Y. Biological and Immunological Properties of Encapsulated Strains of Staphylococcus aureus from Human Sources. Infect Immun. 1970 Nov;2(5):528–532. doi: 10.1128/iai.2.5.528-532.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Yoshida K., Takeuchi Y. Comparison of Compact and Diffuse Variants of Strains of Staphylococcus aureus. Infect Immun. 1970 Nov;2(5):523–527. doi: 10.1128/iai.2.5.523-527.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]

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