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. 1979 Jul;25(1):170–174. doi: 10.1128/iai.25.1.170-174.1979

Cellular and humoral immune responses to varicella-zoster virus in immunocompromised patients during and after varicella-zoster infections.

A A Gershon, S P Steinberg
PMCID: PMC414434  PMID: 225270

Abstract

Humoral and cell-mediated immune responses to varicella-zoster (V-Z) virus were assessed in patients during and after V-Z infections. Ongoing V-Z infections was associated with minimal cellular immunity but not necessarily with poor humoral immunity. Recovery from V-Z infection was associated with a vigorous cellular immune response. Cell-mediated immunity to V-Z virus was demonstrable for years after varicella, but responses were lower in immunocompromised patients than in normal individuals.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Feldman S., Hughes W. T., Daniel C. B. Varicella in children with cancer: Seventy-seven cases. Pediatrics. 1975 Sep;56(3):388–397. [PubMed] [Google Scholar]
  2. Gershon A. A., Krugman S. Seroepidemiologic survey of varicella: Value of specific fluorescent antibody test. Pediatrics. 1975 Dec;56(6):1005–1008. [PubMed] [Google Scholar]
  3. Gershon A. A., Steinberg S. P. Cell-mediated immunity to varicella-zoster virus measured by virus inactivation: mechanism and blocking of the reaction by specific antibody. Infect Immun. 1979 Jul;25(1):164–169. doi: 10.1128/iai.25.1.164-169.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Gershon A. A., Steinberg S., Smith M. Cell-mediated immunity to varicella-zoster virus demonstrated by viral inactivation with human leukocytes. Infect Immun. 1976 Jun;13(6):1549–1553. doi: 10.1128/iai.13.6.1549-1553.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hoppe R. T., Fuks Z. Y., Strober S., Kaplan H. S. The long term effects of radiation of T and B lymphocytes in the peripheral blood after regional irradiation. Cancer. 1977 Nov;40(5):2071–2078. doi: 10.1002/1097-0142(197711)40:5<2071::aid-cncr2820400513>3.0.co;2-v. [DOI] [PubMed] [Google Scholar]
  6. Jordan G. W., Merigan T. C. Cell-mediated immunity to varicella-zoster virus: in vitro lymphocyte responses. J Infect Dis. 1974 Nov;130(5):495–501. doi: 10.1093/infdis/130.5.495. [DOI] [PubMed] [Google Scholar]
  7. Merigan T. C., Stevens D. A. Viral infections in man associated with acquired immunological deficiency states. Fed Proc. 1971 Nov-Dec;30(6):1858–1864. [PubMed] [Google Scholar]
  8. Rand K. H., Rasmussen L. E., Pollard R. B., Arvin A., Merigan T. C. Cellular immunity and herpesvirus infections in cardiac-transplant patients. N Engl J Med. 1977 Jun 16;296(24):1372–1377. doi: 10.1056/NEJM197706162962402. [DOI] [PubMed] [Google Scholar]
  9. Ruckdeschel J. C., Schimpff S. C., Smyth A. C., Mardiney M. R., Jr Herpes zoster and impaired cell-associated immunity to the varicella-zoster virus in patients with Hodgkin's disease. Am J Med. 1977 Jan;62(1):77–85. doi: 10.1016/0002-9343(77)90352-7. [DOI] [PubMed] [Google Scholar]
  10. Russell A. S., Maini R. A., Bailey M., Dumonde D. C. Cell-mediated immunity to Varicella-Zoster antigen in acute Herpes zoster (shingles). Clin Exp Immunol. 1973 Jun;14(2):181–185. [PMC free article] [PubMed] [Google Scholar]
  11. Williams V., Gershon A., Brunell P. A. Serologic response to varicella-zoster membrane antigens measured by direct immunofluorescence. J Infect Dis. 1974 Dec;130(6):669–672. doi: 10.1093/infdis/130.6.669. [DOI] [PubMed] [Google Scholar]

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