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. 1979 Jul;25(1):366–375. doi: 10.1128/iai.25.1.366-375.1979

Efficacy of antimicrobial therapy in experimental rat pneumonia: effects of impaired phagocytosis.

I A Bakker-Woudenberg, J Y de Jong-Hoenderop, M F Michel
PMCID: PMC414461  PMID: 478640

Abstract

The importance of intact host defense mechanisms for successful antimicrobial therapy was investigated in an animal model. Recovery from lobar pneumococcal pneumonia as a result of penicillin therapy was studied in normal rats and in rats treated with cobra venom factor. This factor was used to selectively suppress the phagocytosis of pneumococci as a result of complement depletion. Although complete recovery from the infection occurred in normal rats after appropriate penicillin therapy, this was not the case in cobra venom factor-treated rats. Within the limitations of this study, evidence is presented for loss of antibiotic activity as a consequence of impaired phagocytosis.

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Selected References

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