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. 1979 Sep;25(3):960–963. doi: 10.1128/iai.25.3.960-963.1979

Immunochemical cross-reactions between type III group B Streptococcus and type 14 Streptococcus pneumoniae.

M H Crumrine, G W Fischer, M W Balk
PMCID: PMC414541  PMID: 40876

Abstract

Serological cross-reactions between certain streptococci and some serotypes of Streptococcus pneumoniae have been reported. These studies detail the serological cross-reactivity observed between hot HCl-extracted group b streptococcus type III (GBS III) antigens and S. pneumoniae type 14 (Pn 14) polysaccharide. Similar electrophoretic migration patterns of GBS III and Pn 14 were observed when either type-specific BGS III antisera or pneumococcal omniserum was utilized to precipitate these antigens. Both the GBS III antigen and the Pn 14 polysaccharide migrated toward the cathode, whereas all other pneumococcal polysaccharides migrated toward the anode. No cross-reactions were observed between GBS III antisera and the 11 other types of pneumococcal polysaccharides. Lines of identity were observed between type-specific GBS III antisera and monospecific Pn 14 antiserum with either GBS III antigens or purified Pn 14 polysaccharide. The cross-reacting antigens of GBS III and Pn 14 appear to be identical by immunodiffusion and immunoelectrophoresis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baker C. J., Barrett F. F., Gordon R. C., Yow M. D. Suppurative meningitis due to streptococci of Lancefield group B: a study of 33 infants. J Pediatr. 1973 Apr;82(4):724–729. doi: 10.1016/s0022-3476(73)80606-7. [DOI] [PubMed] [Google Scholar]
  2. Baker C. J., Kasper D. L. Correlation of maternal antibody deficiency with susceptibility to neonatal group B streptococcal infection. N Engl J Med. 1976 Apr 1;294(14):753–756. doi: 10.1056/NEJM197604012941404. [DOI] [PubMed] [Google Scholar]
  3. Baker C. J., Kasper D. L., Davis C. E. Immunochemical characterization of the "native" type III polysaccharide of group B Streptococcus. J Exp Med. 1976 Feb 1;143(2):258–270. doi: 10.1084/jem.143.2.258. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bobitt J. R., Ledger W. J. Obstetric observations in eleven cases of neonatal sepsis due to the group B beta hemolytic streptococcus. Obstet Gynecol. 1976 Apr;47(4):439–442. [PubMed] [Google Scholar]
  5. Bortolussi R., Thompson T. R., Ferrieri P. Early-onset pneumococcal sepsis in newborn infants. Pediatrics. 1977 Sep;60(3):352–355. [PubMed] [Google Scholar]
  6. Fischer G. W., Lowell G. H., Crumrine M. H., Bass J. W. Demonstration of opsonic activity and in vivo protection against group B streptococci type III by Streptococcus pneumoniae type 14 antisera. J Exp Med. 1978 Sep 1;148(3):776–786. doi: 10.1084/jem.148.3.776. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Howard J. B., McCracken G. H., Jr The spectrum of group B streptococcal infections in infancy. Am J Dis Child. 1974 Dec;128(6):815–818. doi: 10.1001/archpedi.1974.02110310063011. [DOI] [PubMed] [Google Scholar]
  8. Kasper D. L., Baker C. J., Baltimore R. S., Crabb J. H., Schiffman G., Jennings H. J. Immunodeterminant specificity of human immunity to type III group B streptococcus. J Exp Med. 1979 Feb 1;149(2):327–339. doi: 10.1084/jem.149.2.327. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kenny G. E., Wentworth B. B., Beasley R. P., Foy H. M. Correlation of circulating capsular polysaccharide with bacteremia in pneumococcal pneumonia. Infect Immun. 1972 Oct;6(4):431–437. doi: 10.1128/iai.6.4.431-437.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Klesius P. H., Zimmerman R. A., Mathews J. H., Krushak D. H. Cellular and humoral immune response to group B streptococci. J Pediatr. 1973 Dec;83(6):926–932. doi: 10.1016/s0022-3476(73)80525-6. [DOI] [PubMed] [Google Scholar]
  11. Lancefield R. C., Freimer E. H. Type-specific polysaccharide antigens of group B streptococci. J Hyg (Lond) 1966 Jun;64(2):191–203. doi: 10.1017/s0022172400040456. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Lindberg B., Lönngren J., Powell D. A. Structural studies on the specific type-14 pneumococcal polysaccharide. Carbohydr Res. 1977 Sep;58(1):177–186. doi: 10.1016/s0008-6215(00)83413-8. [DOI] [PubMed] [Google Scholar]
  13. Mathews J. H., Klesius P. H., Zimmerman R. A. Opsonin system of the group B streptococcus. Infect Immun. 1974 Dec;10(6):1315–1320. doi: 10.1128/iai.10.6.1315-1320.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. McCARTY M., LANCEFIELD R. C. Variation in the group-specific carbohydrate of group A streptococci. I. Immunochemical studies on the carbohydrates of variant strains. J Exp Med. 1955 Jul 1;102(1):11–28. doi: 10.1084/jem.102.1.11. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Russell H., Norcross N. L. The isolation and some physiochemical and biologic properties of the type 3 antigen of group B streptococci. J Immunol. 1972 Jul;109(1):90–96. [PubMed] [Google Scholar]
  16. SCHEIDEGGER J. J. Une micro-méthode de l'immuno-electrophorèse. Int Arch Allergy Appl Immunol. 1955;7(2):103–110. [PubMed] [Google Scholar]

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