Skip to main content
PMC home page
Infection and Immunity logoLink to Infection and Immunity
. 1974 Feb;9(2):410–415. doi: 10.1128/iai.9.2.410-415.1974

Mycoplasma-Associated Immunosuppression: Effect on Hemagglutinin Response to Common Antigens in Rabbits

Lois M Bergquist 1, Benjamin H S Lau 1, Charles E Winter 1
PMCID: PMC414818  PMID: 4593344

Abstract

A Mycoplasma-associated immunosuppression of the primary and secondary hemagglutinin response to a common gram-negative antigen of Escherichia coli (014) was demonstrated in the rabbit when preincubated mixtures of common gram-negative antigen and Mycoplasma arthritidis membranes were injected intravenously. A similar immunosuppression was demonstrated only for the secondary hemagglutinin response to a common gram-positive antigen of Staphylococcus aureus when preincubated mixtures of common gram-positive antigen and M. arthritidis membranes were employed as immunizing materials. The immunosuppressive effect occurred with small quantities of M. arthritidis membranes and appeared not to be limited to the host in which arthritogenic properties of the organism were manifested.

Full text

PDF
411

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ABRAMOFF P., WOLFE H. R. Precipitin production in chickens. XIII. A quantitative study of the effect of simultaneous injection of two antigens. J Immunol. 1956 Aug;77(2):94–101. [PubMed] [Google Scholar]
  2. Bartholomew L. E. Characterization of mycoplasma strains and antibody studies from patients with rheumatoid arthritis. Ann N Y Acad Sci. 1967 Jul 28;143(1):522–534. doi: 10.1111/j.1749-6632.1967.tb27699.x. [DOI] [PubMed] [Google Scholar]
  3. Cahill J. F., Cole B. C., Wiley B. B., Ward J. R. Role of Biological Mimicry in the Pathogenesis of Rat Arthritis Induced by Mycoplasma arthritidis. Infect Immun. 1971 Jan;3(1):24–35. doi: 10.1128/iai.3.1.24-35.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Chorpenning F. W., Dodd M. C. Heterogenetic antigens of gram-positive bacteria. J Bacteriol. 1966 Apr;91(4):1440–1445. doi: 10.1128/jb.91.4.1440-1445.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Coke B. C., Ward J. R., Golightly-Rowland C., Trapp G. A. Chronic proliferative arthritis of mice induced by Mycoplasma arthritidis. II. Serological responses of the lost and effect of vaccines. Infect Immun. 1971 Oct;4(4):431–440. doi: 10.1128/iai.4.4.431-440.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Cole B. C., Cahill J. F., Wiley B. B., Ward J. R. Immunological responses of the rat to Mycoplasma arthritidis. J Bacteriol. 1969 Jun;98(3):930–937. doi: 10.1128/jb.98.3.930-937.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Cole B. C., Golightly-Rowland L., Ward J. R., Wiley B. B. Immunological response of rodents to murine mycoplasmas. Infect Immun. 1970 Oct;2(4):419–425. doi: 10.1128/iai.2.4.419-425.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Cole B. C., Golightly L., Ward J. R. Characterization of mycoplasma strains from cats. J Bacteriol. 1967 Nov;94(5):1451–1458. doi: 10.1128/jb.94.5.1451-1458.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Cole B. C., Ward J. R., Jones R. S., Cahill J. F. Chronic proliferative arthritis of mice induced by Mycoplasma arthritidis. I. Induction of disease and histopathological characteristics. Infect Immun. 1971 Oct;4(4):344–355. doi: 10.1128/iai.4.4.344-355.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Golightly-Rowland L., Cole B. C., Ward J. R., Wiley B. B. Effect of Animal Passage on Arthritogenic and Biological Properties of Mycoplasma arthritidis. Infect Immun. 1970 Jun;1(6):538–545. doi: 10.1128/iai.1.6.538-545.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Hammarström S., Carlsson H. E., Perlmann P., Svensson S. Immunochemistry of the common antigen of Enterobacteriaceae (Kunin). Relation to lipopolysaccharide core structure. J Exp Med. 1971 Sep 1;134(3 Pt 1):565–576. doi: 10.1084/jem.134.3.565. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Jackson R. W., Moskowitz M. Nature of a red cell sensitizing substance from streptococci. J Bacteriol. 1966 Jun;91(6):2205–2209. doi: 10.1128/jb.91.6.2205-2209.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Kaklamanis E., Pavlatos M. The immunosuppressive effect of mycoplasma infection. I. Effect on the humoral and cellular response. Immunology. 1972 Apr;22(4):695–702. [PMC free article] [PubMed] [Google Scholar]
  14. MOWBRAY J. F. Ability of large doses of an alpha-2 plasma protein fraction to inhibit antibody production. Immunology. 1963 May;6:217–225. [PMC free article] [PubMed] [Google Scholar]
  15. Moskowitz M. Separation and properties of a red cell sensitizing substance from streptococci. J Bacteriol. 1966 Jun;91(6):2200–2204. doi: 10.1128/jb.91.6.2200-2204.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. RANTZ L. A., RANDALL E., ZUCKERMAN A. Hemolysis and hemagglutination by normal and immune serums of erythrocytes treated with a nonspecies specific bacterial substance. J Infect Dis. 1956 Mar-Apr;98(2):211–222. doi: 10.1093/infdis/98.2.211. [DOI] [PubMed] [Google Scholar]
  17. TAYLOR-ROBINSON D., SOMERSON N. L., TURNER H. C., CHANOCK R. M. SEROLOGICAL RELATIONSHIPS AMONG HUMAN MYCOPLASMAS AS SHOWN BY COMPLEMENT-FIXATION AND GEL DIFFUSION. J Bacteriol. 1963 Jun;85:1261–1273. doi: 10.1128/jb.85.6.1261-1273.1963. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Whang H. Y., Neter E. Antigen-associated immunosuppressant: effect of serum on immune response. Science. 1969 Jan 17;163(3864):290–291. doi: 10.1126/science.163.3864.290. [DOI] [PubMed] [Google Scholar]
  19. Whang H. Y., Neter E. Chlorphenesin: an antigen-associated immunosuppressant. Infect Immun. 1970 Jul;2(1):60–64. doi: 10.1128/iai.2.1.60-64.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Whang H. Y., Neter E. Immunosuppression by endotoxin and its lipoid A component. Proc Soc Exp Biol Med. 1967 Mar;124(3):919–924. doi: 10.3181/00379727-124-31886. [DOI] [PubMed] [Google Scholar]
  21. Whang H. Y., Neter E. Inhibtion by cardiolipin of the antibody response to bacterial antigens. J Immunol. 1968 Mar;100(3):501–506. [PubMed] [Google Scholar]
  22. Williams M. H., Brostoff J., Roitt I. M. Possible role of Mycoplasma fermentans in pathogenesis of rheumatoid arthritis. Lancet. 1970 Aug 8;2(7667):277–280. doi: 10.1016/s0140-6736(70)91328-0. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES