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. 1974 Jun;9(6):1123–1125. doi: 10.1128/iai.9.6.1123-1125.1974

Influence of Sex and Age on Natural Resistance to St. Louis Encephalitis Virus Infection in Mice

Arthur A Andersen a,1, Robert P Hanson a
PMCID: PMC414942  PMID: 4857422

Abstract

A difference was observed in susceptibility of adult male and female mice to St. Louis encephalitis (SLE) virus as measured by the death rate after intravenous challenge. Female mice that had susceptibility similar to that of males at 2 months of age had increased resistance to SLE virus at 3 and 4 months of age. The increased resistance occurred after sexual maturity, indicating that the resistance factor possibly was related to an aging process in the female. The susceptibility of male mice remained unchanged over the 2- to 4-month period. Neither pregnancy nor castration had any effect on resistance of adult mice to St. Louis encephalitis virus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andersen A. A., Hanson R. P. Experimental transplacental transmission of st. Louis encephalitis virus in mice. Infect Immun. 1970 Sep;2(3):320–325. doi: 10.1128/iai.2.3.320-325.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Berjivich S., Ressel M. Effect of sex on susceptibility of adult mice to coxsackie B1 virus infection. Arch Gesamte Virusforsch. 1967;22(1):246–251. doi: 10.1007/BF01240519. [DOI] [PubMed] [Google Scholar]
  3. Farber P. A., Glasgow L. A. Factors Modifying Host Resistance to Virus Infection: II. Enhanced Susceptibility of Mice to Encephalomyocarditis Virus Infection During Pregnancy. Am J Pathol. 1968 Sep;53(3):463–481. [PMC free article] [PubMed] [Google Scholar]
  4. Friedman S. B., Grota L. J., Glasgow L. A. Differential susceptibility of male and female mice to encephalomyocarditis virus: effects of castration, adrenalectomy, and the administration of sex hormones. Infect Immun. 1972 May;5(5):637–644. doi: 10.1128/iai.5.5.637-644.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. HURST E. W., MELVIN P. A., THORP J. M. The influence of sex on equine encephalomyelitis in the mouse and on its treatment with mepacrine. J Comp Pathol. 1960 Jul;70:346–360. doi: 10.1016/s0368-1742(60)80033-1. [DOI] [PubMed] [Google Scholar]
  6. RANZENHOFER E. R., ALEXANDER E. R., BEADLE L. D., BERNSTEIN A., PICKARD R. C. St. Louis encephalitis in Calvert City, Kentucky, 1955; an epidemiologic study. Am J Hyg. 1957 Mar;65(2):147–161. doi: 10.1093/oxfordjournals.aje.a119862. [DOI] [PubMed] [Google Scholar]
  7. Schell K., Lane W. T. Viral tumor induction: importance of sex and route of inoculation. Lab Anim Care. 1968 Oct;18(5):513–519. [PubMed] [Google Scholar]
  8. Schlegel R. J., Bellanti J. A. Increased susceptibility of males to infection. Lancet. 1969 Oct 18;2(7625):826–827. doi: 10.1016/s0140-6736(69)92278-8. [DOI] [PubMed] [Google Scholar]
  9. WASHBURN T. C., MEDEARIS D. N., Jr, CHILDS B. SEX DIFFERENCES IN SUSCEPTIBILITY TO INFECTIONS. Pediatrics. 1965 Jan;35:57–64. [PubMed] [Google Scholar]
  10. Yohn D. S., Funk C. A., Kalnins V. I., Grace J. T., Jr Sex-related resistance in hamsters to adenovirus-12 oncogenesis. Influence of thymectomy at three weeks of age. J Natl Cancer Inst. 1965 Oct;35(4):617–624. [PubMed] [Google Scholar]

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