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. 1975 Jun;11(6):1278–1283. doi: 10.1128/iai.11.6.1278-1283.1975

Effect of Trace Metals on Phagocytosis by Alveolar Macrophages

Judith A Graham 1, Donald E Gardner 1, Michael D Waters 1, David L Coffin 1
PMCID: PMC415211  PMID: 49299

Abstract

Experiments were performed to measure the effect of trace metals on a vital function of the alveolar macrophage (AM), phagocytosis. Since certain trace metals were found to reduce the viability of AMs, a technique was developed to permit examination of live cells only for phagocytosis. Evidence is presented that Ni2+ selectively altered the phagocytic activity of AMs at concentrations lower than those which caused cell death. It is further shown that a level of VO3− that caused extensive lysis and death did not reduce phagocytosis in surviving cells. The effects of Cd2+, Cr3+, and Mn2+ on AMs were also examined.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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