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. 1975 Jun;11(6):1375–1381. doi: 10.1128/iai.11.6.1375-1381.1975

Occurrence of BK Virus and BK Virus-Specific Antibodies in the Urine of Patients Receiving Chemotherapy for Malignancy

Joan M Reese 1, Magdalena Reissig 1, Richard W Daniel 1, Keerti V Shah 1
PMCID: PMC415225  PMID: 166919

Abstract

Urine specimens from 23 children and 9 adults who were undergoing treatment for malignancy as well as urines from 40 normal individuals were concentrated and examined for evidence of papovavirus infection. Papovavirus particles were detected in 6 of 64 urines examined by electron microscopy. Three of the particle-positive urines induced BK virus-specific immunofluorescence after inoculation of WI38 cells, and three isolations of BK virus were made by inoculation of urines from virus-excreting patients into Vero cells. BK virus-specific hemagglutination-inhibiting and immunofluorescence neutralizing antibodies were found in a majority of urines from adult patients, in about a fifth of pediatric patients, and less often in normal urines. Urines of virus-excreting patients generally had antibodies. In indirect fluorescent antibody tests, BK virus-specific antibodies of the immunoglobulin G class were found in five urine specimens from patients; immunoglobulin A antibodies were not detected in any urine. These data suggest that activation of BK virus is related to immunosuppression and not to transplantation itself and that the occurrence of virus-specific antibodies in urine may be indicative of virus multiplication in the urinary tract.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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