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. 1975 Nov;12(5):1058–1064. doi: 10.1128/iai.12.5.1058-1064.1975

Effect of cyclophosphamide on the response of chickens to a virulent strain of Marek's disease virus.

V Kermani-Arab, T Moll, B R Cho, W C Davis, Y S Lu
PMCID: PMC415397  PMID: 172451

Abstract

The effect of cyclophosphamide on the pathogenesis of Marek's disease was examined in a line of chickens which is relatively resistant to Marek's disease. The injection of cyclophosphamide into newly hatched chickens delayed and reduced viremia and also reduced the development of Marek's disease lesions until 2 weeks after exposure to Marek's disease virus. The data indicate that a population of T cells susceptible to infection with virus and possibly viral transformation is affected by cyclophosphamide.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aulisio C. G., Shelokov A. Detection of microbial antibodies in chickens: immunofluorescence studies with serum and egg yolk. Proc Soc Exp Biol Med. 1969 Sep;131(4):1150–1153. doi: 10.3181/00379727-131-34058. [DOI] [PubMed] [Google Scholar]
  2. Burg R. W., Feldbush T., Morris C. A., Maag T. A. Depression of thymus-and bursa-dependent immune systems chicks with Marek's disease. Avian Dis. 1971 Oct-Dec;15(4):662–671. [PubMed] [Google Scholar]
  3. Calnek B. W. Influence of age at exposure on the pathogenesis of Marek's disease. J Natl Cancer Inst. 1973 Sep;51(3):929–939. doi: 10.1093/jnci/51.3.929. [DOI] [PubMed] [Google Scholar]
  4. Cho B. R., Kenzy S. G. Isolation and characterization of an isolate (HN) of Marek's disease virus with low pathogenicity. Appl Microbiol. 1972 Sep;24(3):299–306. doi: 10.1128/am.24.3.299-306.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Churchill A. E., Biggs P. M. Agent of Marek's disease in tissue culture. Nature. 1967 Jul 29;215(5100):528–530. doi: 10.1038/215528a0. [DOI] [PubMed] [Google Scholar]
  6. Edelman G. M., Gall W. E., Waxdal M. J., Konigsberg W. H. The covalent structure of a human gamma G-immunoglobulin. I. Isolation and characterization of the whole molecule, the polypeptide chains, and the tryptic fragments. Biochemistry. 1968 May;7(5):1950–1958. doi: 10.1021/bi00845a045. [DOI] [PubMed] [Google Scholar]
  7. Evans D. L., Patterson L. T. Correlation of immunological responsiveness with lymphocyte changes in chickens infected with Marek's disease. Infect Immun. 1971 Nov;4(5):567–574. doi: 10.1128/iai.4.5.567-574.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. FAHEY J. L., MCKELVEY E. M. QUANTITATIVE DETERMINATION OF SERUM IMMUNOGLOBULINS IN ANTIBODY-AGAR PLATES. J Immunol. 1965 Jan;94:84–90. [PubMed] [Google Scholar]
  9. Frommel D., Perey D. Y., Good R. A. Metabolism of gamma G and gamma M immunoglobulins in normal and hypogammaglobulinemic chickens. J Immunol. 1970 Jul;105(1):1–6. [PubMed] [Google Scholar]
  10. Hudson L., Payne L. N. An analysis of the T and B cells of Marek's disease lymphomas of the chicken. Nat New Biol. 1973 Jan 10;241(106):52–53. doi: 10.1038/newbio241052a0. [DOI] [PubMed] [Google Scholar]
  11. Ianconescu M., Samberg Y. Etiological and immunological studies in Marek's disease. II. Incidence of Marek's disease precipitating antibodies in commercial flocks and in eggs. Avian Dis. 1971 Jan-Mar;15(1):177–186. [PubMed] [Google Scholar]
  12. Jakowski R. M., Fredrickson T. N., Luginbuhl R. E. Immunoglobulin response in experimental infection with cell-free and cell-associated Marek's disease virus. J Immunol. 1973 Jul;111(1):238–248. [PubMed] [Google Scholar]
  13. Kenzy S. G., Cho B. R. Transmission of classical Marek's disease by affected and carrier birds. Avian Dis. 1969 Feb;13(1):211–214. [PubMed] [Google Scholar]
  14. Lebacq-Verheyden A. M., Vaerman J. P., Heremans J. F. A possible homologue of mammalian IgA in chicken serum and secretions. Immunology. 1972 Jan;22(1):165–175. [PMC free article] [PubMed] [Google Scholar]
  15. Leslie G. A., Clem L. W. Chicken immunoglobulins: biological half-lives and normal adult serum concentrations of IgM and IgY. Proc Soc Exp Biol Med. 1970 May;134(1):195–198. doi: 10.3181/00379727-134-34758. [DOI] [PubMed] [Google Scholar]
  16. Leslie G. A., Clem L. W. Phylogen of immunoglobulin structure and function. 3. Immunoglobulins of the chicken. J Exp Med. 1969 Dec 1;130(6):1337–1352. doi: 10.1084/jem.130.6.1337. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Linna T. J., Frommel D., Good R. A. Effects of early cyclophosphamide treatment on the development of lymphoid organs and immunological functions in the chickens. Int Arch Allergy Appl Immunol. 1972;42(1):20–39. doi: 10.1159/000230590. [DOI] [PubMed] [Google Scholar]
  18. Lu Y. S., Lapen R. F. Splenic cell mitogenic response in Marek's disease: comparison between noninfected tumor-bearing and nontumor-bearing infected chickens. Am J Vet Res. 1974 Jul;35(7):977–980. [PubMed] [Google Scholar]
  19. Nazerian K., Solomon J. J., Witter R. L., Burmester B. R. Studies on the etiology of Marek's disease. II. Finding of a herpesvirus in cell culture. Proc Soc Exp Biol Med. 1968 Jan;127(1):177–182. doi: 10.3181/00379727-127-32650. [DOI] [PubMed] [Google Scholar]
  20. Okazaki W., Purchase H. G., Noll L. Effect of different conditions on precipitation in agar between Marek's disease antigen and antibody. Avian Dis. 1970 Aug;14(3):532–537. [PubMed] [Google Scholar]
  21. Payne L. N. Immunosuppressive effects of avian oncogenic viruses. Proc R Soc Med. 1970 Jan;63(1):16–19. [PMC free article] [PubMed] [Google Scholar]
  22. Polak L., Turk J. L. Reversal of immunological tolerance by cyclophosphamide through inhibition of suppressor cell activity. Nature. 1974 Jun 14;249(458):654–656. doi: 10.1038/249654a0. [DOI] [PubMed] [Google Scholar]
  23. Purchase H. G., Chubb R. C., Biggs P. M. Effect of lymphoid leukosis and Marek's disease on the immunological responsiveness of the chicken. J Natl Cancer Inst. 1968 Mar;40(3):583–592. [PubMed] [Google Scholar]
  24. Purchase H. G., Sharma J. M. Amelioration of Marek's disease and absence of vaccine protection in immunologically deficient chickens. Nature. 1974 Mar 29;248(447):419–421. doi: 10.1038/248419a0. [DOI] [PubMed] [Google Scholar]
  25. Rouse B. T., Wells R. J., Warner N. L. Proportion of T and B lymphocytes in lesions of Marek's disease: theoretical implications for pathogenesis. J Immunol. 1973 Feb;110(2):534–539. [PubMed] [Google Scholar]
  26. Sharma J. M., Davis W. C., Kenzy S. G. Etiologic relationship of skin tumors (skin leukosis) of chickens to Marek's disease. J Natl Cancer Inst. 1970 Apr;44(4):901–911. [PubMed] [Google Scholar]
  27. Sharma J. M. Resistance to Marek's disease in immunologically deficient chickens. Nature. 1974 Jan 11;247(5436):117–118. doi: 10.1038/247117a0. [DOI] [PubMed] [Google Scholar]
  28. Smith M. W., Calnek B. W. High-virulence Marek's disease virus infection in chickens previously infected with low-virulence virus. J Natl Cancer Inst. 1974 May;52(5):1595–1603. doi: 10.1093/jnci/52.5.1595. [DOI] [PubMed] [Google Scholar]
  29. Solomon J. J., Witter R. L., Nazerian K., Burmester B. R. Studies on the etiology of Marek's disease. I. Propagation of the agent in cell culture. Proc Soc Exp Biol Med. 1968 Jan;127(1):173–177. doi: 10.3181/00379727-127-32649. [DOI] [PubMed] [Google Scholar]
  30. Spencer J. L., Calnek B. W. Marek's disease: application of immunofluorescence for detection of antigen and antibody. Am J Vet Res. 1970 Feb;31(2):345–358. [PubMed] [Google Scholar]
  31. Stedman R. A., Singleton L., Box P. G. Purification of Newcastle disease virus antibody from the egg yolk of the hen. J Comp Pathol. 1969 Oct;79(4):507–516. doi: 10.1016/0021-9975(69)90071-1. [DOI] [PubMed] [Google Scholar]
  32. Toivanen P., Toivanen A. Bursal and postbursal stem cells in chicken. Functional characteristics. Eur J Immunol. 1973 Sep;3(9):585–595. doi: 10.1002/eji.1830030912. [DOI] [PubMed] [Google Scholar]
  33. Toivanen P., Toivanen A. Selective activation of chicken T lymphocytes by concanavalin A. J Immunol. 1973 Nov;111(5):1602–1603. [PubMed] [Google Scholar]

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