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. 1976 Nov;14(5):1156–1166. doi: 10.1128/iai.14.5.1156-1166.1976

Isolation of a low-molecular-weight antibacterial system from human amniotic fluid.

P Schlievert, W Johnson, R P Galask
PMCID: PMC415508  PMID: 789241

Abstract

A low-molecular-weight antibacterial system has been isolated from human amniotic fluid. The bacterial inhibitor requires the metal cation zinc and a peptide with a molecular weight of 630. The peptide component was purified using ultrafiltration, gel filtration, and ion-exchange chromatography. It can be inactivated by digestion with carboxypeptidase. The amino acid composition of the peptide is: 3 glutamine-glutamic acid, 2 glycine, and 1 lysine. Removal of zinc from the peptide has been shown to remove bacterial inhibitory activity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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