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. 1970 Oct;2(4):419–425. doi: 10.1128/iai.2.4.419-425.1970

Immunological Response of Rodents to Murine Mycoplasmas

B C Cole 1, L Golightly-Rowland 1, J R Ward 1, B B Wiley 1
PMCID: PMC416026  PMID: 16557855

Abstract

Mycoplasma arthritidis, M. pulmonis, M. neurolyticum, and M. felis strains administered on various immunization schedules induced complement-fixing and agglutinating antibodies in rats, mice, and guinea pigs. Metabolic inhibiting (MI) antibodies against M. felis were produced by guinea pigs, mice, and rats. M. neurolyticum did not induce MI antibody in mice but induced high titers in guinea pigs and rats. M. pulmonis failed to induce MI antibody titers in mice, induced low titers in rats, and induced high titers in guinea pigs. M. arthritidis induced no or very low titers in rats and low titers in mice, but induced high MI titers in guinea pigs. A positive correlation was demonstrated between ability of the mycoplasma to induce disease and lack of MI antibody formation by its natural host. It is suggested that the apparent inability of the various animals to produce MI antibodies against their natural mycoplasmal parasites may enable the mycoplasmas to become established in their hosts. The concept of biological mimicry is brought forward to explain these observations.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ADLER H. E., DAMASSA A. J. ENHANCEMENT OF MYCOPLASMA AGGLUTINATION TITERS BY USE OF ANTI-GLOBULIN. Proc Soc Exp Biol Med. 1964 Jul;116:608–610. doi: 10.3181/00379727-116-29318. [DOI] [PubMed] [Google Scholar]
  2. CHANOCK R. M., HAYFLICK L., BARILE M. F. Growth on artificial medium of an agent associated with atypical pneumonia and its identification as a PPLO. Proc Natl Acad Sci U S A. 1962 Jan 15;48:41–49. doi: 10.1073/pnas.48.1.41. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cole B. C., Cahill J. F., Wiley B. B., Ward J. R. Immunological responses of the rat to Mycoplasma arthritidis. J Bacteriol. 1969 Jun;98(3):930–937. doi: 10.1128/jb.98.3.930-937.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cole B. C., Ward J. R., Martin C. H. Hemolysin and peroxide activity of Mycoplasma species. J Bacteriol. 1968 Jun;95(6):2022–2030. doi: 10.1128/jb.95.6.2022-2030.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hayflick L. Tissue cultures and mycoplasmas. Tex Rep Biol Med. 1965 Jun;23(Suppl):285+–285+. [PubMed] [Google Scholar]
  6. Purcell R. H., Taylor-Robinson D., Wong D. C., Chanock R. M. A color test for the measurement of antibody to the non-acid-forming human Mycoplasma species. Am J Epidemiol. 1966 Jul;84(1):51–66. doi: 10.1093/oxfordjournals.aje.a120627. [DOI] [PubMed] [Google Scholar]
  7. Sabin A. B. ISOLATION OF A FILTRABLE, TRANSMISSIBLE AGENT WITH "NEUROLYTI" PROPERTIES FROM TOXOPLASMA-INFECTED TISSUES. Science. 1938 Aug 26;88(2278):189–191. doi: 10.1126/science.88.2278.189. [DOI] [PubMed] [Google Scholar]
  8. Smith C. B., Chanock R. M., Friedewald W. T., Alford R. H. Mycoplasma pneumoniae infections in volunteers. Ann N Y Acad Sci. 1967 Jul 28;143(1):471–483. doi: 10.1111/j.1749-6632.1967.tb27691.x. [DOI] [PubMed] [Google Scholar]
  9. TULLY J. G. ERYTHROCYTE-MODIFYING CAPACITY AND SEROLOGICAL REACTIVITY OF CELL COMPONENTS OF HUMAN MYCOPLASMA (PPLO) STRAINS. Proc Soc Exp Biol Med. 1963 Dec;114:704–709. doi: 10.3181/00379727-114-28776. [DOI] [PubMed] [Google Scholar]
  10. TULLY J. G. PRODUCTION AND BIOLOGICAL CHARACTERISTICS OF AN EXTRACELLULAR NEUROTOXIN FROM MYCOPLASMA NEUROLYTICUM. J Bacteriol. 1964 Aug;88:381–388. doi: 10.1128/jb.88.2.381-388.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Taylor-Robinson D., Berry D. M. The evaluation of the metabolic-inhibition technique for the study of Mycoplasma gallisepticum. J Gen Microbiol. 1969 Jan;55(1):127–137. doi: 10.1099/00221287-55-1-127. [DOI] [PubMed] [Google Scholar]
  12. Taylor-Robinson D., Purcell R. H., Wong D. C., Chanock R. M. A colour test for the measurement of antibody to certain mycoplasma species based upon the inhibition of acid production. J Hyg (Lond) 1966 Mar;64(1):91–104. doi: 10.1017/s0022172400040377. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Thomas L., Aleu F., Bitensky M. W., Davidson M., Gesner B. Studies of PPLO infection. II. The neurotoxin of Mycoplasma neurolyticum. J Exp Med. 1966 Dec 1;124(6):1067–1082. doi: 10.1084/jem.124.6.1067. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Thomas L., Bitensky M. W. Studies of PPLO infection. IV. The neurotoxicity of intact mycoplasmas, and their production of toxin in vivo and in vitro. J Exp Med. 1966 Dec 1;124(6):1089–1098. doi: 10.1084/jem.124.6.1089. [DOI] [PMC free article] [PubMed] [Google Scholar]

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