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. 1970 Nov;2(5):570–573. doi: 10.1128/iai.2.5.570-573.1970

Correlation Between Pathogenicity of Shigella and Intraperitoneal Survival in Mice

Mitsuru Nakamura 1, Kathleen E Jackson 1, W R Cross 1
PMCID: PMC416052  PMID: 16557879

Abstract

Phagocytosis of virulent and avirulent strains of Shigella and Escherichia coli in the mouse peritoneum was studied. A direct correlation between bacterial virulence and resistance to phagocytosis by peritoneal phagocytes was demonstrated. Virulent strains were less readily cleared and were able to multiply to a limited extent within the peritoneal cavity. An epimerase-deficient, rough mutant of S. flexneri 2a was highly susceptible to phagocytosis. Restoration of the cell wall structure in these mutants resulted in a significant increase in their resistance to phagocytosis. Susceptibility to phagocytosis in smooth S. flexneri was age-dependent. Cells from 16-hr cultures were more resistant to removal from the peritoneum than were cells from 48- and 72-hr cultures.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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