Abstract
Allergy characterized by delayed hypersensitivity was induced in populations of mice by injection, respectively, of Staphylococcus aureus and of tubercle bacilli. Eliciting doses of staphylococcal antigen or of old tuberculin antigen were injected subcutaneously into the nape of the neck of samples of these mice. A challenge dose of S. aureus was injected into the site of the eliciting injection, and the subsequent survival curves of the infecting staphylococci were determined by plate counts. Survival of the challenge staphylococci was significantly reduced only when the eliciting antigen was homologous with the inducing antigen. Thus induction and elicitation were specific, but the local resistance was nonspecifically effective against staphylococci.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Dannenberg A. M., Jr Cellular hypersensitivity and cellular immunity in the pathogensis of tuberculosis: specificity, systemic and local nature, and associated macrophage enzymes. Bacteriol Rev. 1968 Jun;32(2):85–102. doi: 10.1128/br.32.2.85-102.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dannenberg A. M., Jr, Meyer O. T., Esterly J. R., Kambara T. The local nature of immunity in tuberculosis, illustrated histochemically in dermal BCG lesions. J Immunol. 1968 May;100(5):931–941. [PubMed] [Google Scholar]
- KAPRAL F. A., LI I. W. Virulence and coagulases of Staphylococcus aureus. Proc Soc Exp Biol Med. 1960 May;104:151–153. doi: 10.3181/00379727-104-25761. [DOI] [PubMed] [Google Scholar]
- Mackaness G. B., Blanden R. V. Cellular immunity. Prog Allergy. 1967;11:89–140. [PubMed] [Google Scholar]
- Mackaness G. B. The influence of immunologically committed lymphoid cells on macrophage activity in vivo. J Exp Med. 1969 May 1;129(5):973–992. doi: 10.1084/jem.129.5.973. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Taubler J. H., Mudd S. Staphylococcal delayed hypersensitivity in mice. II. In vitro demonstration and specificity of delayed hypersensitivity. J Immunol. 1968 Sep;101(3):550–555. [PubMed] [Google Scholar]
- Taubler J. H. Staphylococcal delayed hypersensitivity in mice. I. Induction and in vivo demonstration of delayed hypersensitivity. J Immunol. 1968 Sep;101(3):546–549. [PubMed] [Google Scholar]