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. 1971 Feb;3(2):268–273. doi: 10.1128/iai.3.2.268-273.1971

Age-Dependent Resistance of Mice to Sindbis Virus Infection: Viral Replication as a Function of Host Age

A B G Reinarz a,1, M G Broome a,2, B P Sagik a
PMCID: PMC416142  PMID: 16557964

Abstract

The development of resistance of outbred white mice to two plaque size variants of Sindbis virus was studied as a function of host age. A sudden drop in mortality occurred over a 3-day period. As little as 1 plaque-forming unit (PFU) per mouse was lethal in 1-day-old animals, whereas inocula of 109 PFU per mouse failed to produce high mortality in weanlings. A comparison of viral growth kinetics shows that early replication was similar in newborns and weanlings but that after 6 to 8 hr the production rate and, therefore, the maximal viral titer were suppressed in weanlings. The data demonstrate a lethal viral threshold. Titers in excess of this level lead to mortality, whereas those below it allow survival.

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Selected References

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