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. 1971 Feb;3(2):268–273. doi: 10.1128/iai.3.2.268-273.1971

Age-Dependent Resistance of Mice to Sindbis Virus Infection: Viral Replication as a Function of Host Age

A B G Reinarz a,1, M G Broome a,2, B P Sagik a
PMCID: PMC416142  PMID: 16557964

Abstract

The development of resistance of outbred white mice to two plaque size variants of Sindbis virus was studied as a function of host age. A sudden drop in mortality occurred over a 3-day period. As little as 1 plaque-forming unit (PFU) per mouse was lethal in 1-day-old animals, whereas inocula of 109 PFU per mouse failed to produce high mortality in weanlings. A comparison of viral growth kinetics shows that early replication was similar in newborns and weanlings but that after 6 to 8 hr the production rate and, therefore, the maximal viral titer were suppressed in weanlings. The data demonstrate a lethal viral threshold. Titers in excess of this level lead to mortality, whereas those below it allow survival.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CLARKE D. H., CASALS J. Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses. Am J Trop Med Hyg. 1958 Sep;7(5):561–573. doi: 10.4269/ajtmh.1958.7.561. [DOI] [PubMed] [Google Scholar]
  2. Cole G. A., Wisseman C. L., Jr Pathogenesis of type 1 dengue virus infection in suckling, weanling and adult mice. 1. The relation of virus replication to interferon and antibody formation. Am J Epidemiol. 1969 Jun;89(6):669–680. doi: 10.1093/oxfordjournals.aje.a120981. [DOI] [PubMed] [Google Scholar]
  3. EAGLE H. Nutrition needs of mammalian cells in tissue culture. Science. 1955 Sep 16;122(3168):501–514. doi: 10.1126/science.122.3168.501. [DOI] [PubMed] [Google Scholar]
  4. Giron D. J. Role of interferon in the propagation of MM virus in L cells. Appl Microbiol. 1969 Oct;18(4):584–588. doi: 10.1128/am.18.4.584-588.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. HEINEBERG H., GOLD E., ROBBINS F. C. DIFFERENCES IN INTERFERON CONTENT IN TISSUES OF MICE OF VARIOUS AGES INFECTED WITH COXSACKIE B1 VIRUS. Proc Soc Exp Biol Med. 1964 Apr;115:947–953. doi: 10.3181/00379727-115-29086. [DOI] [PubMed] [Google Scholar]
  6. JOHNSON R. T. VIRUS INVASION OF THE CENTRAL NERVOUS SYSTEM: A STUDY OF SINDBIS VIRUS INFECTION IN THE MOUSE USING FLUORESCENT ANTIBODY. Am J Pathol. 1965 Jun;46:929–943. [PMC free article] [PubMed] [Google Scholar]
  7. Lavelle G. C., Starr T. J. Interferon response and age-related resistance of germfree mice to mouse hepatitis virus. J Reticuloendothel Soc. 1968 Oct;5(5):422–435. [PubMed] [Google Scholar]
  8. MARENNIKOVA S. S., KAPTSOVA T. I. AGE-DEPENDENCE OF SUSCEPTIBILITY OF WHITE MICE TO VARIOLA VIRUS. Acta Virol. 1965 May;9:230–234. [PubMed] [Google Scholar]
  9. MIMS C. A. ASPECTS OF THE PATHOGENESIS OF VIRUS DISEASES. Bacteriol Rev. 1964 Mar;28:30–71. doi: 10.1128/br.28.1.30-71.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Miller M. E. Phagocytosis in the newborn infant: humoral and cellular factors. J Pediatr. 1969 Feb;74(2):255–259. doi: 10.1016/s0022-3476(69)80073-9. [DOI] [PubMed] [Google Scholar]
  11. Murphy B. R., Glasgow L. A. Factors modifying host resistance to viral infection. 3. Effect of whole body x-irradiation on experimental encephalomyocarditis virus infection in mice. J Exp Med. 1968 May 1;127(5):1035–1052. doi: 10.1084/jem.127.5.1035. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. SAWICKI L. Influence of age of mice on the recovery from experimental Sendal virus infection. Nature. 1961 Dec 30;192:1258–1259. doi: 10.1038/1921258a0. [DOI] [PubMed] [Google Scholar]
  13. SIGEL M. M. Influence of age on susceptibility to virus infections with particular reference to laboratory animals. Annu Rev Microbiol. 1952;6:247–280. doi: 10.1146/annurev.mi.06.100152.001335. [DOI] [PubMed] [Google Scholar]
  14. Subrahmanyan T. P. A study of the possible basis of age-dependent resistance of mice to poxvirus diseases. Aust J Exp Biol Med Sci. 1968 Jun;46(3):251–265. doi: 10.1038/icb.1968.20. [DOI] [PubMed] [Google Scholar]
  15. VILCEK J. PRODUCTION OF INTERFERON BY NEWBORN AND ADULT MICE INFECTED WITH SINDBIS VIRUS. Virology. 1964 Apr;22:651–652. doi: 10.1016/0042-6822(64)90091-1. [DOI] [PubMed] [Google Scholar]

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