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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1995 Jun 6;92(12):5258–5265. doi: 10.1073/pnas.92.12.5258

The causes and prevention of cancer.

B N Ames 1, L S Gold 1, W C Willett 1
PMCID: PMC41674  PMID: 7777494

Abstract

Epidemiological evidence indicates that avoidance of smoking, increased consumption of fruits and vegetables, and control of infections will have a major effect on reducing rates of cancer. Other factors include avoidance of intense sun exposure, increases in physical activity, and reduction of alcohol consumption and possibly red meat. A substantial reduction in breast cancer is likely to require modification of sex hormone levels, and development of practical methods for doing so is a high research priority. Resolution of the potential protective roles of specific antioxidants and other constituents of fruits and vegetables deserves major attention. Mechanistic studies of carcinogenesis indicate an important role of endogenous oxidative damage to DNA that is balanced by elaborate defense and repair processes. Also key is the rate of cell division, which is influenced by hormones, growth, cytotoxicity, and inflammation, as this determines the probability of converting DNA lesions to mutations. These mechanisms may underlie many epidemiologic observations.

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Selected References

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  1. Ames B. N., Gold L. S. Chemical carcinogenesis: too many rodent carcinogens. Proc Natl Acad Sci U S A. 1990 Oct;87(19):7772–7776. doi: 10.1073/pnas.87.19.7772. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Ames B. N., Profet M., Gold L. S. Dietary pesticides (99.99% all natural). Proc Natl Acad Sci U S A. 1990 Oct;87(19):7777–7781. doi: 10.1073/pnas.87.19.7777. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Ames B. N., Profet M., Gold L. S. Nature's chemicals and synthetic chemicals: comparative toxicology. Proc Natl Acad Sci U S A. 1990 Oct;87(19):7782–7786. doi: 10.1073/pnas.87.19.7782. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Ames B. N., Shigenaga M. K., Gold L. S. DNA lesions, inducible DNA repair, and cell division: three key factors in mutagenesis and carcinogenesis. Environ Health Perspect. 1993 Dec;101 (Suppl 5):35–44. doi: 10.1289/ehp.93101s535. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Ames B. N., Shigenaga M. K., Hagen T. M. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):7915–7922. doi: 10.1073/pnas.90.17.7915. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Armstrong B., Doll R. Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices. Int J Cancer. 1975 Apr 15;15(4):617–631. doi: 10.1002/ijc.2910150411. [DOI] [PubMed] [Google Scholar]
  7. Bailey L. B., Wagner P. A., Christakis G. J., Araujo P. E., Appledorf H., Davis C. G., Masteryanni J., Dinning J. S. Folacin and iron status and hematological findings in predominately black elderly persons from urban low-income households. Am J Clin Nutr. 1979 Nov;32(11):2346–2353. doi: 10.1093/ajcn/32.11.2346. [DOI] [PubMed] [Google Scholar]
  8. Bailey L. B., Wagner P. A., Christakis G. J., Davis C. G., Appledorf H., Araujo P. E., Dorsey E., Dinning J. S. Folacin and iron status and hematological findings in black and Spanish-American adolescents from urban low-income households. Am J Clin Nutr. 1982 May;35(5):1023–1032. doi: 10.1093/ajcn/35.5.1023. [DOI] [PubMed] [Google Scholar]
  9. Bates M. N., Smith A. H., Hopenhayn-Rich C. Arsenic ingestion and internal cancers: a review. Am J Epidemiol. 1992 Mar 1;135(5):462–476. doi: 10.1093/oxfordjournals.aje.a116313. [DOI] [PubMed] [Google Scholar]
  10. Beasley R. P. Hepatitis B virus. The major etiology of hepatocellular carcinoma. Cancer. 1988 May 15;61(10):1942–1956. doi: 10.1002/1097-0142(19880515)61:10<1942::aid-cncr2820611003>3.0.co;2-j. [DOI] [PubMed] [Google Scholar]
  11. Bernstein L., Henderson B. E., Hanisch R., Sullivan-Halley J., Ross R. K. Physical exercise and reduced risk of breast cancer in young women. J Natl Cancer Inst. 1994 Sep 21;86(18):1403–1408. doi: 10.1093/jnci/86.18.1403. [DOI] [PubMed] [Google Scholar]
  12. Block G., Patterson B., Subar A. Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence. Nutr Cancer. 1992;18(1):1–29. doi: 10.1080/01635589209514201. [DOI] [PubMed] [Google Scholar]
  13. Block G. The data support a role for antioxidants in reducing cancer risk. Nutr Rev. 1992 Jul;50(7):207–213. doi: 10.1111/j.1753-4887.1992.tb01329.x. [DOI] [PubMed] [Google Scholar]
  14. Blot W. J., Li J. Y., Taylor P. R., Guo W., Dawsey S., Wang G. Q., Yang C. S., Zheng S. F., Gail M., Li G. Y. Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. J Natl Cancer Inst. 1993 Sep 15;85(18):1483–1492. doi: 10.1093/jnci/85.18.1483. [DOI] [PubMed] [Google Scholar]
  15. Branda R. F., Sullivan L. M., O'Neill J. P., Falta M. T., Nicklas J. A., Hirsch B., Vacek P. M., Albertini R. J. Measurement of HPRT mutant frequencies in T-lymphocytes from healthy human populations. Mutat Res. 1993 Feb;285(2):267–279. doi: 10.1016/0027-5107(93)90115-v. [DOI] [PubMed] [Google Scholar]
  16. Braun M. M., Caporaso N. E., Page W. F., Hoover R. N. Genetic component of lung cancer: cohort study of twins. Lancet. 1994 Aug 13;344(8920):440–443. doi: 10.1016/s0140-6736(94)91770-1. [DOI] [PubMed] [Google Scholar]
  17. Brown L. M., Everett G. D., Gibson R., Burmeister L. F., Schuman L. M., Blair A. Smoking and risk of non-Hodgkin's lymphoma and multiple myeloma. Cancer Causes Control. 1992 Jan;3(1):49–55. doi: 10.1007/BF00051912. [DOI] [PubMed] [Google Scholar]
  18. Brunk U. T., Jones C. B., Sohal R. S. A novel hypothesis of lipofuscinogenesis and cellular aging based on interactions between oxidative stress and autophagocytosis. Mutat Res. 1992 Sep;275(3-6):395–403. doi: 10.1016/0921-8734(92)90042-n. [DOI] [PubMed] [Google Scholar]
  19. Bui M. H., Sauty A., Collet F., Leuenberger P. Dietary vitamin C intake and concentrations in the body fluids and cells of male smokers and nonsmokers. J Nutr. 1992 Feb;122(2):312–316. doi: 10.1093/jn/122.2.312. [DOI] [PubMed] [Google Scholar]
  20. Cohen S. M., Purtilo D. T., Ellwein L. B. Ideas in pathology. Pivotal role of increased cell proliferation in human carcinogenesis. Mod Pathol. 1991 May;4(3):371–382. [PubMed] [Google Scholar]
  21. Colditz G. A., Stampfer M. J., Willett W. C., Hunter D. J., Manson J. E., Hennekens C. H., Rosner B. A., Speizer F. E. Type of postmenopausal hormone use and risk of breast cancer: 12-year follow-up from the Nurses' Health Study. Cancer Causes Control. 1992 Sep;3(5):433–439. doi: 10.1007/BF00051356. [DOI] [PubMed] [Google Scholar]
  22. Columbano A., Ledda-Columbano G. M., Ennas M. G., Curto M., Chelo A., Pani P. Cell proliferation and promotion of rat liver carcinogenesis: different effect of hepatic regeneration and mitogen induced hyperplasia on the development of enzyme-altered foci. Carcinogenesis. 1990 May;11(5):771–776. doi: 10.1093/carcin/11.5.771. [DOI] [PubMed] [Google Scholar]
  23. Connelly R. R., Spirtas R., Myers M. H., Percy C. L., Fraumeni J. F., Jr Demographic patterns for mesothelioma in the United States. J Natl Cancer Inst. 1987 Jun;78(6):1053–1060. [PubMed] [Google Scholar]
  24. Cunningham M. L., Elwell M. R., Matthews H. B. Relationship of carcinogenicity and cellular proliferation induced by mutagenic noncarcinogens vs carcinogens. III. Organophosphate pesticides vs tris(2,3-dibromopropyl)phosphate. Fundam Appl Toxicol. 1994 Oct;23(3):363–369. doi: 10.1006/faat.1994.1116. [DOI] [PubMed] [Google Scholar]
  25. Cunningham M. L., Maronpot R. R., Thompson M., Bucher J. R. Early responses of the liver of B6C3F1 mice to the hepatocarcinogen oxazepam. Toxicol Appl Pharmacol. 1994 Jan;124(1):31–38. doi: 10.1006/taap.1994.1005. [DOI] [PubMed] [Google Scholar]
  26. Curtis R. E., Boice J. D., Jr, Stovall M., Bernstein L., Greenberg R. S., Flannery J. T., Schwartz A. G., Weyer P., Moloney W. C., Hoover R. N. Risk of leukemia after chemotherapy and radiation treatment for breast cancer. N Engl J Med. 1992 Jun 25;326(26):1745–1751. doi: 10.1056/NEJM199206253262605. [DOI] [PubMed] [Google Scholar]
  27. Davis D. L., Dinse G. E., Hoel D. G. Decreasing cardiovascular disease and increasing cancer among whites in the United States from 1973 through 1987. Good news and bad news. JAMA. 1994 Feb 9;271(6):431–437. [PubMed] [Google Scholar]
  28. Doll R., Peto R. The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. J Natl Cancer Inst. 1981 Jun;66(6):1191–1308. [PubMed] [Google Scholar]
  29. Dorgan J. F., Reichman M. E., Judd J. T., Brown C., Longcope C., Schatzkin A., Campbell W. S., Franz C., Kahle L., Taylor P. R. The relation of reported alcohol ingestion to plasma levels of estrogens and androgens in premenopausal women (Maryland, United States). Cancer Causes Control. 1994 Jan;5(1):53–60. doi: 10.1007/BF01830726. [DOI] [PubMed] [Google Scholar]
  30. Duthie G. G., Arthur J. R., James W. P. Effects of smoking and vitamin E on blood antioxidant status. Am J Clin Nutr. 1991 Apr;53(4 Suppl):1061S–1063S. doi: 10.1093/ajcn/53.4.1061S. [DOI] [PubMed] [Google Scholar]
  31. Dutta A., Ruppert J. M., Aster J. C., Winchester E. Inhibition of DNA replication factor RPA by p53. Nature. 1993 Sep 2;365(6441):79–82. doi: 10.1038/365079a0. [DOI] [PubMed] [Google Scholar]
  32. Ellis M., Lishner M. Second malignancies following treatment in non-Hodgkin's lymphoma. Leuk Lymphoma. 1993 Mar;9(4-5):337–342. doi: 10.3109/10428199309148531. [DOI] [PubMed] [Google Scholar]
  33. Everson R. B., Wehr C. M., Erexson G. L., MacGregor J. T. Association of marginal folate depletion with increased human chromosomal damage in vivo: demonstration by analysis of micronucleated erythrocytes. J Natl Cancer Inst. 1988 Jun 1;80(7):525–529. doi: 10.1093/jnci/80.7.525. [DOI] [PubMed] [Google Scholar]
  34. Fielding J. E. Preventing colon cancer: yet another reason not to smoke. J Natl Cancer Inst. 1994 Feb 2;86(3):162–164. doi: 10.1093/jnci/86.3.162. [DOI] [PubMed] [Google Scholar]
  35. Fontham E. T., Correa P., Reynolds P., Wu-Williams A., Buffler P. A., Greenberg R. S., Chen V. W., Alterman T., Boyd P., Austin D. F. Environmental tobacco smoke and lung cancer in nonsmoking women. A multicenter study. JAMA. 1994 Jun 8;271(22):1752–1759. [PubMed] [Google Scholar]
  36. Fraga C. G., Motchnik P. A., Shigenaga M. K., Helbock H. J., Jacob R. A., Ames B. N. Ascorbic acid protects against endogenous oxidative DNA damage in human sperm. Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11003–11006. doi: 10.1073/pnas.88.24.11003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Freudenheim J. L., Graham S., Marshall J. R., Haughey B. P., Cholewinski S., Wilkinson G. Folate intake and carcinogenesis of the colon and rectum. Int J Epidemiol. 1991 Jun;20(2):368–374. doi: 10.1093/ije/20.2.368. [DOI] [PubMed] [Google Scholar]
  38. Giovannucci E., Ascherio A., Rimm E. B., Colditz G. A., Stampfer M. J., Willett W. C. Physical activity, obesity, and risk for colon cancer and adenoma in men. Ann Intern Med. 1995 Mar 1;122(5):327–334. doi: 10.7326/0003-4819-122-5-199503010-00002. [DOI] [PubMed] [Google Scholar]
  39. Giovannucci E., Colditz G. A., Stampfer M. J., Hunter D., Rosner B. A., Willett W. C., Speizer F. E. A prospective study of cigarette smoking and risk of colorectal adenoma and colorectal cancer in U.S. women. J Natl Cancer Inst. 1994 Feb 2;86(3):192–199. doi: 10.1093/jnci/86.3.192. [DOI] [PubMed] [Google Scholar]
  40. Giovannucci E., Rimm E. B., Ascherio A., Stampfer M. J., Colditz G. A., Willett W. C. Alcohol, low-methionine--low-folate diets, and risk of colon cancer in men. J Natl Cancer Inst. 1995 Feb 15;87(4):265–273. doi: 10.1093/jnci/87.4.265. [DOI] [PubMed] [Google Scholar]
  41. Giovannucci E., Rimm E. B., Colditz G. A., Stampfer M. J., Ascherio A., Chute C. G., Chute C. C., Willett W. C. A prospective study of dietary fat and risk of prostate cancer. J Natl Cancer Inst. 1993 Oct 6;85(19):1571–1579. doi: 10.1093/jnci/85.19.1571. [DOI] [PubMed] [Google Scholar]
  42. Giovannucci E., Rimm E. B., Stampfer M. J., Colditz G. A., Ascherio A., Kearney J., Willett W. C. A prospective study of cigarette smoking and risk of colorectal adenoma and colorectal cancer in U.S. men. J Natl Cancer Inst. 1994 Feb 2;86(3):183–191. doi: 10.1093/jnci/86.3.183. [DOI] [PubMed] [Google Scholar]
  43. Giovannucci E., Rimm E. B., Stampfer M. J., Colditz G. A., Ascherio A., Willett W. C. Aspirin use and the risk for colorectal cancer and adenoma in male health professionals. Ann Intern Med. 1994 Aug 15;121(4):241–246. doi: 10.7326/0003-4819-121-4-199408150-00001. [DOI] [PubMed] [Google Scholar]
  44. Giovannucci E., Rimm E. B., Stampfer M. J., Colditz G. A., Ascherio A., Willett W. C. Intake of fat, meat, and fiber in relation to risk of colon cancer in men. Cancer Res. 1994 May 1;54(9):2390–2397. [PubMed] [Google Scholar]
  45. Giovannucci E., Stampfer M. J., Colditz G. A., Rimm E. B., Trichopoulos D., Rosner B. A., Speizer F. E., Willett W. C. Folate, methionine, and alcohol intake and risk of colorectal adenoma. J Natl Cancer Inst. 1993 Jun 2;85(11):875–884. doi: 10.1093/jnci/85.11.875. [DOI] [PubMed] [Google Scholar]
  46. Glynn S. A., Albanes D. Folate and cancer: a review of the literature. Nutr Cancer. 1994;22(2):101–119. doi: 10.1080/01635589409514336. [DOI] [PubMed] [Google Scholar]
  47. Gold L. S., Bernstein L., Magaw R., Slone T. H. Interspecies extrapolation in carcinogenesis: prediction between rats and mice. Environ Health Perspect. 1989 May;81:211–219. doi: 10.1289/ehp.8981211. [DOI] [PMC free article] [PubMed] [Google Scholar]
  48. Gold L. S., Manley N. B., Slone T. H., Garfinkel G. B., Rohrbach L., Ames B. N. The fifth plot of the Carcinogenic Potency Database: results of animal bioassays published in the general literature through 1988 and by the National Toxicology Program through 1989. Environ Health Perspect. 1993 Apr;100:65–168. doi: 10.1289/ehp.9310065. [DOI] [PMC free article] [PubMed] [Google Scholar]
  49. Gold L. S., Slone T. H., Manley N. B., Ames B. N. Heterocyclic amines formed by cooking food: comparison of bioassay results with other chemicals in the Carcinogenic Potency Database. Cancer Lett. 1994 Aug 15;83(1-2):21–29. doi: 10.1016/0304-3835(94)90294-1. [DOI] [PubMed] [Google Scholar]
  50. Gold L. S., Slone T. H., Stern B. R., Manley N. B., Ames B. N. Rodent carcinogens: setting priorities. Science. 1992 Oct 9;258(5080):261–265. doi: 10.1126/science.1411524. [DOI] [PubMed] [Google Scholar]
  51. Goldbohm R. A., van den Brandt P. A., van 't Veer P., Brants H. A., Dorant E., Sturmans F., Hermus R. J. A prospective cohort study on the relation between meat consumption and the risk of colon cancer. Cancer Res. 1994 Feb 1;54(3):718–723. [PubMed] [Google Scholar]
  52. Gough M. How much cancer can EPA regulate away? Risk Anal. 1990 Mar;10(1):1–6. doi: 10.1111/j.1539-6924.1990.tb01011.x. [DOI] [PubMed] [Google Scholar]
  53. Grasl-Kraupp B., Bursch W., Ruttkay-Nedecky B., Wagner A., Lauer B., Schulte-Hermann R. Food restriction eliminates preneoplastic cells through apoptosis and antagonizes carcinogenesis in rat liver. Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9995–9999. doi: 10.1073/pnas.91.21.9995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  54. Greenberg E. R., Baron J. A., Stukel T. A., Stevens M. M., Mandel J. S., Spencer S. K., Elias P. M., Lowe N., Nierenberg D. W., Bayrd G. A clinical trial of beta carotene to prevent basal-cell and squamous-cell cancers of the skin. The Skin Cancer Prevention Study Group. N Engl J Med. 1990 Sep 20;323(12):789–795. doi: 10.1056/NEJM199009203231204. [DOI] [PubMed] [Google Scholar]
  55. Hanawalt P., Mellon I. Stranded in an active gene. Curr Biol. 1993 Jan;3(1):67–69. doi: 10.1016/0960-9822(93)90156-i. [DOI] [PubMed] [Google Scholar]
  56. Hankinson S. E., Colditz G. A., Hunter D. J., Spencer T. L., Rosner B., Stampfer M. J. A quantitative assessment of oral contraceptive use and risk of ovarian cancer. Obstet Gynecol. 1992 Oct;80(4):708–714. [PubMed] [Google Scholar]
  57. Harris J. R., Lippman M. E., Veronesi U., Willett W. Breast cancer (1) N Engl J Med. 1992 Jul 30;327(5):319–328. doi: 10.1056/NEJM199207303270505. [DOI] [PubMed] [Google Scholar]
  58. Heller T. D., Holt P. R., Richardson A. Food restriction retards age-related histological changes in rat small intestine. Gastroenterology. 1990 Feb;98(2):387–391. doi: 10.1016/0016-5085(90)90829-p. [DOI] [PubMed] [Google Scholar]
  59. Henderson B. E., Ross R. K., Pike M. C., Casagrande J. T. Endogenous hormones as a major factor in human cancer. Cancer Res. 1982 Aug;42(8):3232–3239. [PubMed] [Google Scholar]
  60. Henderson B. E., Ross R. K., Pike M. C. Hormonal chemoprevention of cancer in women. Science. 1993 Jan 29;259(5095):633–638. doi: 10.1126/science.8381558. [DOI] [PubMed] [Google Scholar]
  61. Henderson B. E., Ross R. K., Pike M. C. Toward the primary prevention of cancer. Science. 1991 Nov 22;254(5035):1131–1138. doi: 10.1126/science.1957166. [DOI] [PubMed] [Google Scholar]
  62. Holehan A. M., Merry B. J. Modification of the oestrous cycle hormonal profile by dietary restriction. Mech Ageing Dev. 1985 Oct 14;32(1):63–76. doi: 10.1016/0047-6374(85)90036-3. [DOI] [PubMed] [Google Scholar]
  63. Holliday R. Food, reproduction and longevity: is the extended lifespan of calorie-restricted animals an evolutionary adaptation? Bioessays. 1989 Apr;10(4):125–127. doi: 10.1002/bies.950100408. [DOI] [PubMed] [Google Scholar]
  64. Howe G. R., Hirohata T., Hislop T. G., Iscovich J. M., Yuan J. M., Katsouyanni K., Lubin F., Marubini E., Modan B., Rohan T. Dietary factors and risk of breast cancer: combined analysis of 12 case-control studies. J Natl Cancer Inst. 1990 Apr 4;82(7):561–569. doi: 10.1093/jnci/82.7.561. [DOI] [PubMed] [Google Scholar]
  65. Howson C. P., Hiyama T., Wynder E. L. The decline in gastric cancer: epidemiology of an unplanned triumph. Epidemiol Rev. 1986;8:1–27. doi: 10.1093/oxfordjournals.epirev.a036288. [DOI] [PubMed] [Google Scholar]
  66. Hunter D. J., Willett W. C. Diet, body size, and breast cancer. Epidemiol Rev. 1993;15(1):110–132. doi: 10.1093/oxfordjournals.epirev.a036096. [DOI] [PubMed] [Google Scholar]
  67. Jick H., Walker A. M., Watkins R. N., D'Ewart D. C., Hunter J. R., Danford A., Madsen S., Dinan B. J., Rothman K. J. Replacement estrogens and breast cancer. Am J Epidemiol. 1980 Nov;112(5):586–594. doi: 10.1093/oxfordjournals.aje.a113031. [DOI] [PubMed] [Google Scholar]
  68. Key T., Reeves G. Organochlorines in the environment and breast cancer. BMJ. 1994 Jun 11;308(6943):1520–1521. doi: 10.1136/bmj.308.6943.1520. [DOI] [PMC free article] [PubMed] [Google Scholar]
  69. Knudson A. G., Jr The ninth Gordon Hamilton-Fairley memorial lecture. Hereditary cancers: clues to mechanisms of carcinogenesis. Br J Cancer. 1989 May;59(5):661–666. doi: 10.1038/bjc.1989.137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  70. Korkina L. G., Durnev A. D., Suslova T. B., Cheremisina Z. P., Daugel-Dauge N. O., Afanas'ev I. B. Oxygen radical-mediated mutagenic effect of asbestos on human lymphocytes: suppression by oxygen radical scavengers. Mutat Res. 1992 Feb;265(2):245–253. doi: 10.1016/0027-5107(92)90053-5. [DOI] [PubMed] [Google Scholar]
  71. Lambe M., Hsieh C., Trichopoulos D., Ekbom A., Pavia M., Adami H. O. Transient increase in the risk of breast cancer after giving birth. N Engl J Med. 1994 Jul 7;331(1):5–9. doi: 10.1056/NEJM199407073310102. [DOI] [PubMed] [Google Scholar]
  72. Lane D. P. Cancer. A death in the life of p53. Nature. 1993 Apr 29;362(6423):786–787. doi: 10.1038/362786a0. [DOI] [PubMed] [Google Scholar]
  73. Le Marchand L., Kolonel L. N., Wilkens L. R., Myers B. C., Hirohata T. Animal fat consumption and prostate cancer: a prospective study in Hawaii. Epidemiology. 1994 May;5(3):276–282. doi: 10.1097/00001648-199405000-00004. [DOI] [PubMed] [Google Scholar]
  74. Li R., Botchan M. R. The acidic transcriptional activation domains of VP16 and p53 bind the cellular replication protein A and stimulate in vitro BPV-1 DNA replication. Cell. 1993 Jun 18;73(6):1207–1221. doi: 10.1016/0092-8674(93)90649-b. [DOI] [PubMed] [Google Scholar]
  75. Linet M. S., McLaughlin J. K., Hsing A. W., Wacholder S., Co Chien H. T., Schuman L. M., Bjelke E., Blot W. J. Is cigarette smoking a risk factor for non-Hodgkin's lymphoma or multiple myeloma? Results from the Lutheran Brotherhood Cohort Study. Leuk Res. 1992 Jun-Jul;16(6-7):621–624. doi: 10.1016/0145-2126(92)90011-u. [DOI] [PubMed] [Google Scholar]
  76. Lok E., Scott F. W., Mongeau R., Nera E. A., Malcolm S., Clayson D. B. Calorie restriction and cellular proliferation in various tissues of the female Swiss Webster mouse. Cancer Lett. 1990 May 15;51(1):67–73. doi: 10.1016/0304-3835(90)90232-m. [DOI] [PubMed] [Google Scholar]
  77. Longnecker M. P. Alcoholic beverage consumption in relation to risk of breast cancer: meta-analysis and review. Cancer Causes Control. 1994 Jan;5(1):73–82. doi: 10.1007/BF01830729. [DOI] [PubMed] [Google Scholar]
  78. Lubin J. H. Invited commentary: lung cancer and exposure to residential radon. Am J Epidemiol. 1994 Aug 15;140(4):323–332. doi: 10.1093/oxfordjournals.aje.a117254. [DOI] [PubMed] [Google Scholar]
  79. Létourneau E. G., Krewski D., Choi N. W., Goddard M. J., McGregor R. G., Zielinski J. M., Du J. Case-control study of residential radon and lung cancer in Winnipeg, Manitoba, Canada. Am J Epidemiol. 1994 Aug 15;140(4):310–322. doi: 10.1093/oxfordjournals.aje.a117253. [DOI] [PubMed] [Google Scholar]
  80. MacGregor J. T., Schlegel R., Wehr C. M., Alperin P., Ames B. N. Cytogenetic damage induced by folate deficiency in mice is enhanced by caffeine. Proc Natl Acad Sci U S A. 1990 Dec;87(24):9962–9965. doi: 10.1073/pnas.87.24.9962. [DOI] [PMC free article] [PubMed] [Google Scholar]
  81. Marsh J. P., Mossman B. T. Role of asbestos and active oxygen species in activation and expression of ornithine decarboxylase in hamster tracheal epithelial cells. Cancer Res. 1991 Jan 1;51(1):167–173. [PubMed] [Google Scholar]
  82. Mills P. K., Beeson W. L., Phillips R. L., Fraser G. E. Cancer incidence among California Seventh-Day Adventists, 1976-1982. Am J Clin Nutr. 1994 May;59(5 Suppl):1136S–1142S. doi: 10.1093/ajcn/59.5.1136S. [DOI] [PubMed] [Google Scholar]
  83. Moalli P. A., MacDonald J. L., Goodglick L. A., Kane A. B. Acute injury and regeneration of the mesothelium in response to asbestos fibers. Am J Pathol. 1987 Sep;128(3):426–445. [PMC free article] [PubMed] [Google Scholar]
  84. Newcomb P. A., Storer B. E., Longnecker M. P., Mittendorf R., Greenberg E. R., Clapp R. W., Burke K. P., Willett W. C., MacMahon B. Lactation and a reduced risk of premenopausal breast cancer. N Engl J Med. 1994 Jan 13;330(2):81–87. doi: 10.1056/NEJM199401133300201. [DOI] [PubMed] [Google Scholar]
  85. Pariza M. W., Boutwell R. K. Historical perspective: calories and energy expenditure in carcinogenesis. Am J Clin Nutr. 1987 Jan;45(1 Suppl):151–156. doi: 10.1093/ajcn/45.1.151. [DOI] [PubMed] [Google Scholar]
  86. Patterson B. H., Block G. Food choices and the cancer guidelines. Am J Public Health. 1988 Mar;78(3):282–286. doi: 10.2105/ajph.78.3.282. [DOI] [PMC free article] [PubMed] [Google Scholar]
  87. Patterson B. H., Block G., Rosenberger W. F., Pee D., Kahle L. L. Fruit and vegetables in the American diet: data from the NHANES II survey. Am J Public Health. 1990 Dec;80(12):1443–1449. doi: 10.2105/ajph.80.12.1443. [DOI] [PMC free article] [PubMed] [Google Scholar]
  88. Pershagen G., Akerblom G., Axelson O., Clavensjö B., Damber L., Desai G., Enflo A., Lagarde F., Mellander H., Svartengren M. Residential radon exposure and lung cancer in Sweden. N Engl J Med. 1994 Jan 20;330(3):159–164. doi: 10.1056/NEJM199401203300302. [DOI] [PubMed] [Google Scholar]
  89. Peto R., Lopez A. D., Boreham J., Thun M., Heath C., Jr Mortality from tobacco in developed countries: indirect estimation from national vital statistics. Lancet. 1992 May 23;339(8804):1268–1278. doi: 10.1016/0140-6736(92)91600-d. [DOI] [PubMed] [Google Scholar]
  90. Ponder B. A. Inherited predisposition to cancer. Trends Genet. 1990 Jul;6(7):213–218. doi: 10.1016/0168-9525(90)90181-5. [DOI] [PubMed] [Google Scholar]
  91. Pope C. A., 3rd, Thun M. J., Namboodiri M. M., Dockery D. W., Evans J. S., Speizer F. E., Heath C. W., Jr Particulate air pollution as a predictor of mortality in a prospective study of U.S. adults. Am J Respir Crit Care Med. 1995 Mar;151(3 Pt 1):669–674. doi: 10.1164/ajrccm/151.3_Pt_1.669. [DOI] [PubMed] [Google Scholar]
  92. Prentice R. L., Sheppard L. Dietary fat and cancer: consistency of the epidemiologic data, and disease prevention that may follow from a practical reduction in fat consumption. Cancer Causes Control. 1990 Jul;1(1):81–109. doi: 10.1007/BF00053187. [DOI] [PubMed] [Google Scholar]
  93. Preston-Martin S., Thomas D. C., Yu M. C., Henderson B. E. Diagnostic radiography as a risk factor for chronic myeloid and monocytic leukaemia (CML). Br J Cancer. 1989 Apr;59(4):639–644. doi: 10.1038/bjc.1989.130. [DOI] [PMC free article] [PubMed] [Google Scholar]
  94. Qian G. S., Ross R. K., Yu M. C., Yuan J. M., Gao Y. T., Henderson B. E., Wogan G. N., Groopman J. D. A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People's Republic of China. Cancer Epidemiol Biomarkers Prev. 1994 Jan-Feb;3(1):3–10. [PubMed] [Google Scholar]
  95. Reynolds T. Asbestos-linked cancer rates up less than predicted. J Natl Cancer Inst. 1992 Apr 15;84(8):560–562. [PubMed] [Google Scholar]
  96. Richter C., Park J. W., Ames B. N. Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc Natl Acad Sci U S A. 1988 Sep;85(17):6465–6467. doi: 10.1073/pnas.85.17.6465. [DOI] [PMC free article] [PubMed] [Google Scholar]
  97. Roe F. J., Lee P. N., Conybeare G., Tobin G., Kelly D., Prentice D., Matter B. Risks of premature death and cancer predicted by body weight in early adult life. Hum Exp Toxicol. 1991 Jul;10(4):285–288. doi: 10.1177/096032719101000408. [DOI] [PubMed] [Google Scholar]
  98. Rosner B., Colditz G. A., Willett W. C. Reproductive risk factors in a prospective study of breast cancer: the Nurses' Health Study. Am J Epidemiol. 1994 Apr 15;139(8):819–835. doi: 10.1093/oxfordjournals.aje.a117079. [DOI] [PubMed] [Google Scholar]
  99. Rush D. Periconceptional folate and neural tube defect. Am J Clin Nutr. 1994 Feb;59(2 Suppl):511S–516S. doi: 10.1093/ajcn/59.2.511S. [DOI] [PubMed] [Google Scholar]
  100. Russo J., Calaf G., Sohi N., Tahin Q., Zhang P. L., Alvarado M. E., Estrada S., Russo I. H. Critical steps in breast carcinogenesis. Ann N Y Acad Sci. 1993 Nov 30;698:1–20. doi: 10.1111/j.1749-6632.1993.tb17187.x. [DOI] [PubMed] [Google Scholar]
  101. Ryffel B. The carcinogenicity of ciclosporin. Toxicology. 1992;73(1):1–22. doi: 10.1016/0300-483x(92)90166-c. [DOI] [PubMed] [Google Scholar]
  102. SHANMUGARATNAM K. Primary carcinomas of the liver and biliary tract. Br J Cancer. 1956 Jun;10(2):232–246. doi: 10.1038/bjc.1956.27. [DOI] [PMC free article] [PubMed] [Google Scholar]
  103. Schectman G., Byrd J. C., Hoffmann R. Ascorbic acid requirements for smokers: analysis of a population survey. Am J Clin Nutr. 1991 Jun;53(6):1466–1470. doi: 10.1093/ajcn/53.6.1466. [DOI] [PubMed] [Google Scholar]
  104. Selby C. P., Sancar A. Molecular mechanism of transcription-repair coupling. Science. 1993 Apr 2;260(5104):53–58. doi: 10.1126/science.8465200. [DOI] [PubMed] [Google Scholar]
  105. Selhub J., Jacques P. F., Wilson P. W., Rush D., Rosenberg I. H. Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA. 1993 Dec 8;270(22):2693–2698. doi: 10.1001/jama.1993.03510220049033. [DOI] [PubMed] [Google Scholar]
  106. Senti F. R., Pilch S. M. Analysis of folate data from the second National Health and Nutrition Examination Survey (NHANES II). J Nutr. 1985 Nov;115(11):1398–1402. doi: 10.1093/jn/115.11.1398. [DOI] [PubMed] [Google Scholar]
  107. Shacter E., Beecham E. J., Covey J. M., Kohn K. W., Potter M. Activated neutrophils induce prolonged DNA damage in neighboring cells. Carcinogenesis. 1988 Dec;9(12):2297–2304. doi: 10.1093/carcin/9.12.2297. [DOI] [PubMed] [Google Scholar]
  108. Shigenaga M. K., Hagen T. M., Ames B. N. Oxidative damage and mitochondrial decay in aging. Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):10771–10778. doi: 10.1073/pnas.91.23.10771. [DOI] [PMC free article] [PubMed] [Google Scholar]
  109. Slattery M. L., Schumacher M. C., Smith K. R., West D. W., Abd-Elghany N. Physical activity, diet, and risk of colon cancer in Utah. Am J Epidemiol. 1988 Nov;128(5):989–999. doi: 10.1093/oxfordjournals.aje.a115072. [DOI] [PubMed] [Google Scholar]
  110. Smith A. H., Hopenhayn-Rich C., Bates M. N., Goeden H. M., Hertz-Picciotto I., Duggan H. M., Wood R., Kosnett M. J., Smith M. T. Cancer risks from arsenic in drinking water. Environ Health Perspect. 1992 Jul;97:259–267. doi: 10.1289/ehp.9297259. [DOI] [PMC free article] [PubMed] [Google Scholar]
  111. Stadtman E. R. Protein oxidation and aging. Science. 1992 Aug 28;257(5074):1220–1224. doi: 10.1126/science.1355616. [DOI] [PubMed] [Google Scholar]
  112. Stampfer M. J., Willett W. C. Homocysteine and marginal vitamin deficiency. The importance of adequate vitamin intake. JAMA. 1993 Dec 8;270(22):2726–2727. [PubMed] [Google Scholar]
  113. Steinmetz K. A., Potter J. D. Vegetables, fruit, and cancer. I. Epidemiology. Cancer Causes Control. 1991 Sep;2(5):325–357. doi: 10.1007/BF00051672. [DOI] [PubMed] [Google Scholar]
  114. Steinmetz K. A., Potter J. D. Vegetables, fruit, and cancer. II. Mechanisms. Cancer Causes Control. 1991 Nov;2(6):427–442. doi: 10.1007/BF00054304. [DOI] [PubMed] [Google Scholar]
  115. Tabor E., Kobayashi K. Hepatitis C virus, a causative infectious agent of non-A, non-B hepatitis: prevalence and structure--summary of a conference on hepatitis C virus as a cause of hepatocellular carcinoma. J Natl Cancer Inst. 1992 Jan 15;84(2):86–90. doi: 10.1093/jnci/84.2.86. [DOI] [PubMed] [Google Scholar]
  116. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. N Engl J Med. 1994 Apr 14;330(15):1029–1035. doi: 10.1056/NEJM199404143301501. [DOI] [PubMed] [Google Scholar]
  117. Thun M. J., Calle E. E., Namboodiri M. M., Flanders W. D., Coates R. J., Byers T., Boffetta P., Garfinkel L., Heath C. W., Jr Risk factors for fatal colon cancer in a large prospective study. J Natl Cancer Inst. 1992 Oct 7;84(19):1491–1500. doi: 10.1093/jnci/84.19.1491. [DOI] [PubMed] [Google Scholar]
  118. Trock B., Lanza E., Greenwald P. Dietary fiber, vegetables, and colon cancer: critical review and meta-analyses of the epidemiologic evidence. J Natl Cancer Inst. 1990 Apr 18;82(8):650–661. doi: 10.1093/jnci/82.8.650. [DOI] [PubMed] [Google Scholar]
  119. Venkatachalam S., Denissenko M. F., Alvi N., Wani A. A. Rapid activation of apoptosis in human promyelocytic leukemic cells by (+/-)-anti-benzo[a]pyrene diol epoxide induced DNA damage. Biochem Biophys Res Commun. 1993 Dec 15;197(2):722–729. doi: 10.1006/bbrc.1993.2539. [DOI] [PubMed] [Google Scholar]
  120. Vogelstein B., Fearon E. R., Kern S. E., Hamilton S. R., Preisinger A. C., Nakamura Y., White R. Allelotype of colorectal carcinomas. Science. 1989 Apr 14;244(4901):207–211. doi: 10.1126/science.2565047. [DOI] [PubMed] [Google Scholar]
  121. Wallace D. C. Mitochondrial DNA sequence variation in human evolution and disease. Proc Natl Acad Sci U S A. 1994 Sep 13;91(19):8739–8746. doi: 10.1073/pnas.91.19.8739. [DOI] [PMC free article] [PubMed] [Google Scholar]
  122. Wang A., Yoshimi N., Tanaka T., Mori H. The inhibitory effect of magnesium hydroxide on the bile acid-induced cell proliferation of colon epithelium in rats with comparison to the action of calcium lactate. Carcinogenesis. 1994 Nov;15(11):2661–2663. doi: 10.1093/carcin/15.11.2661. [DOI] [PubMed] [Google Scholar]
  123. Weber B. L., Garber J. E. Family history and breast cancer. Probabilities and possibilities. JAMA. 1993 Oct 6;270(13):1602–1603. [PubMed] [Google Scholar]
  124. Yamashina K., Miller B. E., Heppner G. H. Macrophage-mediated induction of drug-resistant variants in a mouse mammary tumor cell line. Cancer Res. 1986 May;46(5):2396–2401. [PubMed] [Google Scholar]
  125. Yeh F. S., Yu M. C., Mo C. C., Luo S., Tong M. J., Henderson B. E. Hepatitis B virus, aflatoxins, and hepatocellular carcinoma in southern Guangxi, China. Cancer Res. 1989 May 1;49(9):2506–2509. [PubMed] [Google Scholar]
  126. Youngman L. D., Park J. Y., Ames B. N. Protein oxidation associated with aging is reduced by dietary restriction of protein or calories. Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):9112–9116. doi: 10.1073/pnas.89.19.9112. [DOI] [PMC free article] [PubMed] [Google Scholar]
  127. Yu M. C., Tong M. J., Govindarajan S., Henderson B. E. Nonviral risk factors for hepatocellular carcinoma in a low-risk population, the non-Asians of Los Angeles County, California. J Natl Cancer Inst. 1991 Dec 18;83(24):1820–1826. doi: 10.1093/jnci/83.24.1820. [DOI] [PubMed] [Google Scholar]
  128. Yu M. W., You S. L., Chang A. S., Lu S. N., Liaw Y. F., Chen C. J. Association between hepatitis C virus antibodies and hepatocellular carcinoma in Taiwan. Cancer Res. 1991 Oct 15;51(20):5621–5625. [PubMed] [Google Scholar]
  129. zur Hausen H., de Villiers E. M. Human papillomaviruses. Annu Rev Microbiol. 1994;48:427–447. doi: 10.1146/annurev.mi.48.100194.002235. [DOI] [PubMed] [Google Scholar]

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