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. 1995 May 9;92(10):4158–4163. doi: 10.1073/pnas.92.10.4158

Function of the oxidative burst in hypersensitive disease resistance.

R Tenhaken 1, A Levine 1, L F Brisson 1, R A Dixon 1, C Lamb 1
PMCID: PMC41903  PMID: 11607542

Abstract

Microbial elicitors or attempted infection with an avirulent pathogen strain causes the rapid production of reactive oxygen intermediates. Recent findings indicate that H2O2 from this oxidative burst plays a central role in the orchestration of the hypersensitive response: (i) as the substrate driving the cross-linking of cell wall structural proteins to slow microbial ingress prior to the deployment of transcription-dependent defenses and to trap pathogens in cells destined to undergo hypersensitive cell death, (ii) as a local threshold trigger of this programmed death in challenged cells, and (iii) as a diffusible signal for the induction in adjacent cells of genes encoding cellular protectants such as glutathione S-transferase and glutathione peroxidase. These findings provide the basis for an integrated model for the orchestration of the localized hypersensitive resistance response to attack by an avirulent pathogen.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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