Abstract
The histopathological and immunofluorescent findings in tissues within and surrounding artificially created subcutaneous tissue cavities infected with Neisseria gonorrhoeae for 1 to 30 days were studied in mice and guinea pigs. Findings in the tissue cavities of the animal models were similar to the findings of disseminated gonococcal infection in humans. These similarities included an intense persistent polymorphonuclear leukocytic response with tissue necrosis, hemorrhage into the early lesion, a perivascular leukocytic response in adjacent tissue, difficulty in detecting large numbers of discrete morphologically typical gonococci by the tissue Gram stain and direct fluorescent antibody techniques, a decrease in the number of identifiable gonococci with duration of the infection, and moderate amounts of extracellular and intracellular immunofluorescent gonococcal debris. Studies into the pathogenesis of the animal infections may enhance our understanding of the pathogenic mechanism (s) associated with gonococcal infection in humans.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Arko R. J. An immunologic model in laboratory animals for the study of Neisseria gonorrhoeae. J Infect Dis. 1974 Apr;129(4):451–455. doi: 10.1093/infdis/129.4.451. [DOI] [PubMed] [Google Scholar]
- Arko R. J. Implantation and use of a subcutaneous culture chamber in laboratory animals. Lab Anim Sci. 1973 Feb;23(1):105–106. [PubMed] [Google Scholar]
- Arko R. J. Neisseria gonorrhoeae: experimental infection of laboratory animals. Science. 1972 Sep 29;177(4055):1200–1201. doi: 10.1126/science.177.4055.1200. [DOI] [PubMed] [Google Scholar]
- Danielsson D., Michaëlsson G. The gonococcal dermatitis syndrome. Demonstration of gonococci in skin lesions by immunofluorescence. Acta Derm Venereol. 1966;46(2):256–261. [PubMed] [Google Scholar]
- Flynn J., Waitkins S. A. Survival of Neisseria gonorrhoeae in an artificial subcutaneous cavity of the mouse. Br J Vener Dis. 1973 Oct;49(5):432–434. doi: 10.1136/sti.49.5.432. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KELLOGG D. S., Jr, PEACOCK W. L., Jr, DEACON W. E., BROWN L., PIRKLE D. I. NEISSERIA GONORRHOEAE. I. VIRULENCE GENETICALLY LINKED TO CLONAL VARIATION. J Bacteriol. 1963 Jun;85:1274–1279. doi: 10.1128/jb.85.6.1274-1279.1963. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kahn G., Danielsson D. Septic gonococcal dermatitis. Demonstration of gonococci and gonococcal antigens in skin lesions by immunofluorescence. Arch Dermatol. 1969 Apr;99(4):421–425. doi: 10.1001/archderm.99.4.421. [DOI] [PubMed] [Google Scholar]
- Kraus S. J. Complications of gonococcal infection. Med Clin North Am. 1972 Sep;56(5):1115–1125. doi: 10.1016/s0025-7125(16)32337-9. [DOI] [PubMed] [Google Scholar]
- Peacock W. L., Jr Method for preparing Neisseria gonorrhoeae fluorescent antibody conjugate. Public Health Rep. 1970 Aug;85(8):733–738. [PMC free article] [PubMed] [Google Scholar]
- Peacock W. L., Jr, Welch B. G., Martin J. E., Jr, Thayer J. D. Fluroescent antibody technique for identification of presumptively positive gonococcal cultures. Public Health Rep. 1968 Apr;83(4):337–339. [PMC free article] [PubMed] [Google Scholar]
- Scales R. W., Kraus S. J. Development and passive transfer of immunity to gonococcal infection in Guinea pigs. Infect Immun. 1974 Nov;10(5):1040–1043. doi: 10.1128/iai.10.5.1040-1043.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shapiro L., Teisch J. A., Brownstein M. H. Dermatohistopathology of chronic gonococcal sepsis. Arch Dermatol. 1973 Mar;107(3):403–406. [PubMed] [Google Scholar]
- Swanson J., Kraus S. J., Gotschlich E. C. Studies on gonococcus infection. I. Pili and zones of adhesion: their relation to gonococcal growth patterns. J Exp Med. 1971 Oct 1;134(4):886–906. doi: 10.1084/jem.134.4.886. [DOI] [PMC free article] [PubMed] [Google Scholar]