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. 1976 Mar;13(3):934–940. doi: 10.1128/iai.13.3.934-940.1976

Comparison of guinea pig cytomegalovirus and guinea pig herpes-like virus: pathogenesis and persistence in experimentally infected animals.

R B Tenser, G D Hsiung
PMCID: PMC420697  PMID: 178599

Abstract

The pathogenesis of guinea pig cytomegalovirus (GPCMV) and guinea pig herpes-like virus (GPHLV) in guinea pigs was compared. Animals were inoculated with the two viruses by different routes and sacrificed after varying periods of time. GPCMV was consistently isolated from salivary gland 2 weeks postinoculation and thereafter following intraperitoneal or subcutaneous incoulaton. Virus was less frequently found in other tissues including blood, spleen, and kidney. Intranuclear inclusions were seen in tissue sections of salivary gland after inoculation with GPCMV- infected tissue suspension, but were only rarely found after inoculation with tissue culture virus. In GPHLV-infected guinea pigs, consistent latent infection of leukocytes and other tissues was detected by cocultivation techniques. Intranuclear inclusions were not found in the spleen, salivary gland, or other infected tissues after GPHLV infection with either tissue culture virus or infected tissue suspension. Guinea pigs inoculated with GPCMV produced high titers of specific neutralizing antibody to the homologous virus; those inoculated with GPHLV developed long-term viremia accompanied by minimal neutralizing antibody levels to the virus.

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Selected References

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  1. Bhatt P. N., Percy D. H., Craft J. L., Jonas A. M. Isolation and characterization of a herpeslike (Hsiung-Kaplow) virus from guinea pigs. J Infect Dis. 1971 Feb;123(2):178–189. doi: 10.1093/infdis/123.2.178. [DOI] [PubMed] [Google Scholar]
  2. Booss J., Hsiung G. D. Herpes-like virus of the guinea pig: propagation in brain tissue of guinea pigs and mice. J Infect Dis. 1971 Mar;123(3):284–291. doi: 10.1093/infdis/123.3.284. [DOI] [PubMed] [Google Scholar]
  3. Fong C. K., Tenser R. B., Hsiung G. D., Gross P. A. Ultrastructural studies of the envelopment and release of guinea pig herpes-like virus in cultured cells. Virology. 1973 Apr;52(2):468–477. doi: 10.1016/0042-6822(73)90342-5. [DOI] [PubMed] [Google Scholar]
  4. HARTLEY J. W., ROWE W. P., HUEBNER R. J. Serial propagation of the guinea pig salivary gland virus in tissue culture. Proc Soc Exp Biol Med. 1957 Nov;96(2):281–285. doi: 10.3181/00379727-96-23455. [DOI] [PubMed] [Google Scholar]
  5. Hsiung G. D., Fong C. R., Lam K. M. Guinea pig leukocytes: in vivo and in vitro infection with a herpes-like virus. J Immunol. 1971 Jan;106(6):1686–1689. [PubMed] [Google Scholar]
  6. Hsiung G. D., Kaplow L. S., Booss J. Herpesvirus infection of guinea pigs. I. Isolation, characterization and pathogenicity. Am J Epidemiol. 1971 Apr;93(4):298–307. doi: 10.1093/oxfordjournals.aje.a121261. [DOI] [PubMed] [Google Scholar]
  7. Hsiung G. D., Kaplow L. S. Herpeslike virus isolated from spontaneously degenerated tissue culture derived from leukemia-susceptible guinea pigs. J Virol. 1969 Mar;3(3):355–357. doi: 10.1128/jvi.3.3.355-357.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hsiung G. D., Tenser R. B., Fong C. K. Comparison of guinea pig cytomegalovirus and guinea pig herpes-like virus: growth characteristics and antigentic relationship. Infect Immun. 1976 Mar;13(3):926–933. doi: 10.1128/iai.13.3.926-933.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Lam K. M., Hsiung G. D. Herpesvirus infection of guinea pigs. II. Transplacental transmission. Am J Epidemiol. 1971 Apr;93(4):308–313. doi: 10.1093/oxfordjournals.aje.a121262. [DOI] [PubMed] [Google Scholar]
  10. Nayak D. P. Isolation and characterization of a herpesvirus from leukemic guinea pigs. J Virol. 1971 Oct;8(4):579–588. doi: 10.1128/jvi.8.4.579-588.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Rosenbusch C. T., Lucas A. M. Studies on the pathogenicity and cytological reactions of the submaxillary gland virus of the guinea pig. Am J Pathol. 1939 May;15(3):303–340.3. [PMC free article] [PubMed] [Google Scholar]
  12. Tenser R. B., Hsiung G. D. Infection of thymus cells in vivo and in vitro with a guinea pig herpes-like virus and the effect of antibody on virus replication in organ culture. J Immunol. 1973 Feb;110(2):552–560. [PubMed] [Google Scholar]

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