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. 1976 May;13(5):1490–1496. doi: 10.1128/iai.13.5.1490-1496.1976

Nocardia asteroides and Nocardia brasiliensis infections in mice.

P I Folb, R Jaffe, G Altmann
PMCID: PMC420786  PMID: 773837

Abstract

A model for Nocardia asteroides and Nocardia brasiliensis infections in Swiss white mice has been established without the addition to the inocula of any form of adjuvant. Serial histopathological studies revealed that these two actinomycetes cause lesions that are quite different in their features. An acute suppurative abscess characterizes the lesions of N. asteroides. In the case of N. brasiliensis infections a granuloma is produced in which a striking feature is the presence of large numbers of foam-laden macrophages, although occasional exceptions to this pattern were noted. Electron microscopic studies demonstrated that these macrophages contain within their cytoplasm organisms in varying stages of degeneration. Repeated mortality studies in mice failed to demonstrate differences in mortality rates produced by N. asteroides and N. brasiliensis. Thus, despite relatively trivial biochemical and antigenic differences between these two species of Nocardia, the local pathogenic response is quite different. The presence in the "brasiliensis lesion" of foamy macrophages with intracellular organisms is reminiscent of the histopathological features of lepromatous leprosy and of disseminated Myocobacterium bovis infection when this occurs in the immune suppressed situation. It is possible that N. brasiliensis infection produces a depression of cellular immunity that modifies the local host response to the organism.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANDRIOLE V. T., BALLAS M., WILSON G. L. THE ASSOCIATION OF NOCARDIOSIS AND PULMONARY ALVEOLAR PROTEINOSIS. A CASE STUDY. Ann Intern Med. 1964 Feb;60:266–275. doi: 10.7326/0003-4819-60-2-266. [DOI] [PubMed] [Google Scholar]
  2. Bach M. C., Adler J. L., Breman J., P'eng F. K., Sahyoun A., Schlesinger R. M., Madras P., Monaco A. P. Influence of rejection therapy on fungal and nocardial infections in renal-transplant recipients. Lancet. 1973 Jan 27;1(7796):180–184. doi: 10.1016/s0140-6736(73)90007-x. [DOI] [PubMed] [Google Scholar]
  3. GEORG L. K., AJELLO L., McDURMONT C., HOSTY T. S. The identification of Nocardia asteroides and Nocardia brasiliensis. Am Rev Respir Dis. 1961 Sep;84:337–347. doi: 10.1164/arrd.1961.84.3.337. [DOI] [PubMed] [Google Scholar]
  4. Gonzalez Ochoa A. Virulence of nocardiae. Can J Microbiol. 1973 Aug;19(8):901–904. doi: 10.1139/m73-144. [DOI] [PubMed] [Google Scholar]
  5. Krick J. A., Stinson E. B., Remington J. S. Nocardia infection in heart transplant patients. Ann Intern Med. 1975 Jan;82(1):18–26. doi: 10.7326/0003-4819-82-1-18. [DOI] [PubMed] [Google Scholar]
  6. OCHOA A. G. Mycetomas caused by Nocardia brasiliensis; with a note on the isolation of the causative organism from soil. Lab Invest. 1962 Nov;11:1118–1123. [PubMed] [Google Scholar]
  7. Palmer D. L., Harvey R. L., Wheeler J. K. Diagnostic and therapeutic considerations in Nocardia asteroides infection. Medicine (Baltimore) 1974 Sep;53(5):391–401. doi: 10.1097/00005792-197409000-00005. [DOI] [PubMed] [Google Scholar]
  8. Rees R. J., Waters M. F. Recent trends in leprosy research. Br Med Bull. 1972 Jan;28(1):16–21. doi: 10.1093/oxfordjournals.bmb.a070885. [DOI] [PubMed] [Google Scholar]
  9. Sher N. A., Chaparas S. D., Greenberg L. E., Merchant E. B., Vickers J. H. Response of congenitally athymic (nude) mice to infection with Mycobacterium bovis (strain BCG). J Natl Cancer Inst. 1975 Jun;54(6):1419–1426. doi: 10.1093/jnci/54.6.1419. [DOI] [PubMed] [Google Scholar]
  10. Smith I. M., Hayward A. H. Nocardia caviae and Nocardia asteroides: comparative bacteriological and mouse pathogenicity studies. J Comp Pathol. 1971 Jan;81(1):79–87. doi: 10.1016/0021-9975(71)90058-2. [DOI] [PubMed] [Google Scholar]
  11. Turk J. L., Bryceson A. D. Immunological phenomena in leprosy and related diseases. Adv Immunol. 1971;13:209–266. doi: 10.1016/s0065-2776(08)60185-6. [DOI] [PubMed] [Google Scholar]
  12. Uesaka I., Oiwa K., Yasuhira K., Kobara Y., McClung N. M. Studies on the pathogenicity of Nocardia isolates for mice. Jpn J Exp Med. 1971 Oct;41(5):443–457. [PubMed] [Google Scholar]

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