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. 1976 Jun;13(6):1579–1584. doi: 10.1128/iai.13.6.1579-1584.1976

Genetic analysis of lymphocyte activation by lipopolysaccharide Endotoxin.

B M Sultzer
PMCID: PMC420803  PMID: 1085749

Abstract

A genetic study of in vitro lymphocyte blastogenesis by the B-cell mitogen lipopolysaccharide endotoxin has been performed, using both low-responder C3H/HeJ mice and high-responder CBA/J mice. The crossbreeding of these strains produced F1 progeny that were intermediate in responsiveness. Responder types from the backcross of the F1 to the C3H/HeJ strain segregated into intermediate- and low-responder phenotypes, whereas intermediate- and high-responder phenotypes were produced from the backcross of the F1 to the CBA/J strain. The F2 generation consisted of all three responder phenotypes in frequencies that fit the classical Mendelian ratio of 1:2:1, indicating that the mitogenic response to lipopolysaccharide endotoxin in mice is most likely governed by a pair of autosomal co-dominant genes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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