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. 1977 Jun;16(3):725–729. doi: 10.1128/iai.16.3.725-729.1977

Adjuvanticity (immunity-inducing property) of cord factor in mice and rats.

R Saito, S Nagao, M Takamoto, K Sugiyama, A Tanaka
PMCID: PMC421020  PMID: 70404

Abstract

Cord factor, a glycolipid in mycobacteria, was found to make a tolerogenic protein antigen immunogenic when injected 0 to 2 days before tolerogen injection in mice and rats. Cord factor was also found to increase phagocytic function of the reticuloendothelial system of mice, and the relationship between the immunity-inducing capacity and the phagocytic function is discussed.

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Selected References

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  1. BIOZZI G., BENACERRAF B., HALPERN B. N. The effect of Salm. typhi and its endotoxin on the phagocytic activity of the reticuloendothelial system in mice. Br J Exp Pathol. 1955 Jun;36(3):226–235. [PMC free article] [PubMed] [Google Scholar]
  2. Behling U. H., Campbell B., Chang C. M., Rumpf C., Nowotny A. Synthetic glycolipid adjuvants. J Immunol. 1976 Sep;117(3):847–851. [PubMed] [Google Scholar]
  3. Bekierkunst A., Yarkoni E., Flechner I., Morecki S., Vilkas E., Lederer E. Immune response to sheep red blood cells in mice pretreated with mycobacterial fractions. Infect Immun. 1971 Sep;4(3):256–263. doi: 10.1128/iai.4.3.256-263.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. CLAMAN H. N. TOLERANCE TO A PROTEIN ANTIGEN IN ADULT MICE AND THE EFFECT OF NONSPECIFIC FACTORS. J Immunol. 1963 Dec;91:833–839. [PubMed] [Google Scholar]
  5. Cruchaud A. The effect of reticuloendothelial blockade on antibody formation and immunologic tolerance. Lab Invest. 1968 Jul;19(1):15–24. [PubMed] [Google Scholar]
  6. DRESSER D. W. Effectiveness of lipid and lipidophilic substances as adjuvants. Nature. 1961 Sep 16;191:1169–1171. doi: 10.1038/1911169a0. [DOI] [PubMed] [Google Scholar]
  7. Das S., Leskowitz S. The cellular basis for tolerance or immunity to bovine-gamma-globulin in mice. J Immunol. 1974 Jan;112(1):107–114. [PubMed] [Google Scholar]
  8. Dresser D. W. An assay for adjuvanticity. Clin Exp Immunol. 1968 Nov;3(9):877–888. [PMC free article] [PubMed] [Google Scholar]
  9. Ellouz F., Adam A., Ciorbaru R., Lederer E. Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives. Biochem Biophys Res Commun. 1974 Aug 19;59(4):1317–1325. doi: 10.1016/0006-291x(74)90458-6. [DOI] [PubMed] [Google Scholar]
  10. FREI P. C., BENACERRAF B., THORBECKE G. J. PHAGOCYTOSIS OF THE ANTIGEN, A CRUCIAL STEP IN THE INDUCTION OF THE PRIMARY RESPONSE. Proc Natl Acad Sci U S A. 1965 Jan;53:20–23. doi: 10.1073/pnas.53.1.20. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Golub E. S., Weigle W. O. Studies on the induction of immunologic unresponsiveness. 3. Antigen form and mouse strain variation. J Immunol. 1969 Feb;102(2):389–396. [PubMed] [Google Scholar]
  12. Golub E. S., Weigle W. O. Studies on the induction of immunologic unresponsiveness. I. Effects of endotoxin and phytochemagglutinin. J Immunol. 1967 Jun;98(6):1241–1247. [PubMed] [Google Scholar]
  13. Granger D. L., Yamamoto K. I., Ribi E. Delayed hypersensitivity and granulomatous response after immunization with protein antigens associated with a mycobacterial glycolipid and oil droplets. J Immunol. 1976 Feb;116(2):482–488. [PubMed] [Google Scholar]
  14. Ishizaka K., Adachi T. Generation of specific helper cells and suppressor cells in vitro for the IgE and IgG antibody responses. J Immunol. 1976 Jul;117(1):40–47. [PubMed] [Google Scholar]
  15. Johnson H. M., Brenner K., Hall H. E. The use of a wate-soluble carbodiimide as a coupling reagent in the passive hemagglutination test. J Immunol. 1966 Dec;97(6):791–796. [PubMed] [Google Scholar]
  16. Kawaguchi S. Studies on the induction of immunological paralysis to bovine gamma-globulin in adult mice. II. The effect of cyclophosphamide. Immunology. 1970 Aug;19(2):291–299. [PMC free article] [PubMed] [Google Scholar]
  17. Louis J. A., Chiller J. M., Weigle W. O. The ability of bacterial lipopolysaccharide to modulate the induction of unresponsiveness to a state of immunity. Cellular parameters. J Exp Med. 1973 Dec 1;138(6):1481–1495. doi: 10.1084/jem.138.6.1481. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Lukić M. L., Cowing C., Leskowitz S. Strain differences in ease of tolerance induction to bovine gamma-globulin: dependence on macrophage function. J Immunol. 1975 Jan;114(1 Pt 2):503–506. [PubMed] [Google Scholar]
  19. Nakano M., Tanabe M. J., Saito T., Shimizu T. Immunosuppressive effect of bacterial lipopolysaccharide on antibody response. Jpn J Microbiol. 1976 Feb;20(1):53–58. doi: 10.1111/j.1348-0421.1976.tb00907.x. [DOI] [PubMed] [Google Scholar]
  20. Neill V. M., Hyde R. M. The induction of immune tolerance in mice during reticuloendothelial system blockade. J Reticuloendothel Soc. 1973 May;13(5):449–458. [PubMed] [Google Scholar]
  21. Saito R., Tanaka A., Sugiyama K., Azuma I., Yamamura Y. Adjuvant effect of cord factor, a mycobacterial lipid. Infect Immun. 1976 Mar;13(3):776–781. doi: 10.1128/iai.13.3.776-781.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Saito R. [Adjuvant effect of cord factor, a Mycobacterial lipid component (author's transl)]. Kekkaku. 1975 May;50(4-5):91–103. [PubMed] [Google Scholar]
  23. Tanaka A., Ishibashi T., Sugiyama K., Takamoto M. Immunological adjuvants. VI. An acetylated mycobacterial adjuvant lacking competing antigenicity. Z Immunitatsforsch Exp Klin Immunol. 1971 Nov;142(4):303–317. [PubMed] [Google Scholar]

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