Skip to main content
Infection and Immunity logoLink to Infection and Immunity
. 1977 Sep;17(3):504–509. doi: 10.1128/iai.17.3.504-509.1977

Effect of warfarin on the induction and course of experimental Staphylococcus epidermidis endocarditis.

L Thörig, J Thompson, F Eulderink
PMCID: PMC421152  PMID: 903174

Abstract

The effect of warfarin treatment on an experimental Staphylococcus epidermidis endocarditis was studied. Warfarin was found to affect both the induction and course of the infection of catheter-induced endocardial vegetations. In warfarin-treated rabbits, larger bacterial inocula were needed to induce an infection, and the degree of infection of the vegetations was also significantly lower, eventually resulting in the total elimination of the bacteria from the vegetations. Thus, warfarin treatment seems to have an inhibitory effect on the induction and development of an S. epidermidis infection of the endocardium. The results differ from previous findings in studies done with Streptococcus anguis, where warfarin was found to have no effect on the induction or course of the infection of endocardial vegetations, which suggests that different mechanisms are involved in the pathogenesis of endocarditis caused by these two species of bacteria.

Full text

PDF
507

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Durack D. T., Beeson P. B. Experimental bacterial endocarditis. I. Colonization of a sterile vegetation. Br J Exp Pathol. 1972 Feb;53(1):44–49. [PMC free article] [PubMed] [Google Scholar]
  2. Durack D. T., Beeson P. B. Experimental bacterial endocarditis. II. Survival of a bacteria in endocardial vegetations. Br J Exp Pathol. 1972 Feb;53(1):50–53. [PMC free article] [PubMed] [Google Scholar]
  3. Durack D. T. Experimental bacterial endocarditis. IV. Structure and evolution of very early lesions. J Pathol. 1975 Feb;115(2):81–89. doi: 10.1002/path.1711150204. [DOI] [PubMed] [Google Scholar]
  4. Garrison P. K., Freedman L. R. Experimental endocarditis I. Staphylococcal endocarditis in rabbits resulting from placement of a polyethylene catheter in the right side of the heart. Yale J Biol Med. 1970 Jun;42(6):394–410. [PMC free article] [PubMed] [Google Scholar]
  5. Gibbons R. J., Houte J. V. Bacterial adherence in oral microbial ecology. Annu Rev Microbiol. 1975;29:19–44. doi: 10.1146/annurev.mi.29.100175.000315. [DOI] [PubMed] [Google Scholar]
  6. Gould K., Ramirez-Ronda C. H., Holmes R. K., Sanford J. P. Adherence of bacteria to heart valves in vitro. J Clin Invest. 1975 Dec;56(6):1364–1370. doi: 10.1172/JCI108216. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Guckian J. C. Effect of pneumococci on blood clotting, platelets, and polymorphonuclear leukocytes. Infect Immun. 1975 Oct;12(4):910–918. doi: 10.1128/iai.12.4.910-918.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hook E. W., 3rd, Sande M. A. Role of the vegetation in experimental Streptococcus viridans endocarditis. Infect Immun. 1974 Dec;10(6):1433–1438. doi: 10.1128/iai.10.6.1433-1438.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Thompson J., Eulderink F., Lemkes H., van Furth R. Effect of warfarin on the induction and course of experimental endocarditis. Infect Immun. 1976 Dec;14(6):1284–1289. doi: 10.1128/iai.14.6.1284-1289.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Weinstein L., Rubin R. H. Infective endocarditis--1973. Prog Cardiovasc Dis. 1973 Nov-Dec;16(3):239–274. doi: 10.1016/s0033-0620(73)80001-5. [DOI] [PubMed] [Google Scholar]
  11. Weinstein L., Schlesinger J. J. Pathoanatomic, pathophysiologic and clinical correlations in endocarditis (first of two parts). N Engl J Med. 1974 Oct 17;291(16):832–837. doi: 10.1056/NEJM197410172911609. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES