Skip to main content
PMC home page
Infection and Immunity logoLink to Infection and Immunity
. 1977 Oct;18(1):196–202. doi: 10.1128/iai.18.1.196-202.1977

Transplacental transmission of polyoma virus in mice.

D J McCance, C A Mims
PMCID: PMC421213  PMID: 198373

Abstract

When pregnant mice were inoculated on day 1 of gestation with polyoma, some of them exhibited total resorption or reduced litter size, the extent depending on the dose of virus. Virus was detected in 4 out of 11 mouse embryo fibroblast (MEF) cultures made from infected mothers. After maternal infection on day 5 or 10 of gestation, virus titers of up to 10(7) 50% tissue culture infectious doses (TCID50)/g of fetus were found in all pools of fetuses tested 5 days later, with the titers falling by day 6. Hemagglutination-inhibiting antibodies against polyoma appeared in maternal serum by day 6 and rose to a maximum by day 14. Immunoglobulin G class antibodies were detected by day 7, with titers rising rapidly to a maximum at day 14. After maternal infection later in gestation (day 15), one out of three litters of newborn mice was found to have 10(5) TCID50 polyoma virus per g in pooled kidney samples.

Full text

PDF
199

Images in this article

199Image
on p.199

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BUFFETT R. F., LEVINTHAL J. D. Polyoma virus infection in mice. Pathogenesis. Arch Pathol. 1962 Dec;74:513–526. [PubMed] [Google Scholar]
  2. Brown P., Tsai T., Gajdusek D. C. Seroepidemiology of human papovaviruses. Discovery of virgin populations and some unusual patterns of antibody prevalence among remote peoples of the world. Am J Epidemiol. 1975 Oct;102(4):331–340. doi: 10.1093/oxfordjournals.aje.a112169. [DOI] [PubMed] [Google Scholar]
  3. Dudgeon J. A. Infective causes of human malformations. Br Med Bull. 1976 Jan;32(1):77–83. doi: 10.1093/oxfordjournals.bmb.a071328. [DOI] [PubMed] [Google Scholar]
  4. Gardner S. D., Field A. M., Coleman D. V., Hulme B. New human papovavirus (B.K.) isolated from urine after renal transplantation. Lancet. 1971 Jun 19;1(7712):1253–1257. doi: 10.1016/s0140-6736(71)91776-4. [DOI] [PubMed] [Google Scholar]
  5. Gardner S. D. Prevalence in England of antibody to human polyomavirus (B.k.). Br Med J. 1973 Jan 13;1(5845):77–78. doi: 10.1136/bmj.1.5845.77. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Mims C. A. Pathogenesis of viral infections of the fetus. Prog Med Virol. 1968;10:194–237. [PubMed] [Google Scholar]
  7. Padgett B. L., Walker D. L. Prevalence of antibodies in human sera against JC virus, an isolate from a case of progressive multifocal leukoencephalopathy. J Infect Dis. 1973 Apr;127(4):467–470. doi: 10.1093/infdis/127.4.467. [DOI] [PubMed] [Google Scholar]
  8. Petrucco O. M., Seamark R. F., Holmes K., Forbes I. J., Symons R. G. Changes in lymphocyte function during pregnancy. Br J Obstet Gynaecol. 1976 Mar;83(3):245–250. doi: 10.1111/j.1471-0528.1976.tb00818.x. [DOI] [PubMed] [Google Scholar]
  9. Portolani M., Marzocchi A., Barbanti-Brodano G., La Placa M. Prevalence in Italy of antibodies to a new human papovavirus (BK virus). J Med Microbiol. 1974 Nov;7(4):543–546. doi: 10.1099/00222615-7-4-543. [DOI] [PubMed] [Google Scholar]
  10. ROWE W. P., HARTLEY J. W., ESTES J. D., HUEBNER R. J. Growth curves of polyoma virus in mice and hamsters. Natl Cancer Inst Monogr. 1960 Sep;4:189–209. [PubMed] [Google Scholar]
  11. ROWE W. P., HARTLEY J. W., ESTES J. D., HUEBNER R. J. Studies of mouse polyoma virus infection. 1. Procedures for quantitation and detection of virus. J Exp Med. 1959 Apr 1;109(4):379–391. doi: 10.1084/jem.109.4.379. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Reissig M., Kelly T. J., Jr, Daniel R. W., Rangan S. R., Shah K. V. Identification of the stumptailed macaque virus as a new papovavirus. Infect Immun. 1976 Jul;14(1):225–231. doi: 10.1128/iai.14.1.225-231.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Shah K. V., Rangan S. R., Reissig M., Daniel R. W., Bellhan F. Z. Congenital transmission of a papovavirus of the stump-tailed macaque. Science. 1977 Jan 28;195(4276):404–406. doi: 10.1126/science.401546. [DOI] [PubMed] [Google Scholar]
  14. Taguchi F., Nagaki D., Saito M., Haruyama C., Iwasaki K. Transplacental transmission of BK virus in human. Jpn J Microbiol. 1975 Oct;19(5):395–398. doi: 10.1111/j.1348-0421.1975.tb00897.x. [DOI] [PubMed] [Google Scholar]
  15. Takemoto K. K., Rabson A. S., Mullarkey M. F., Blaese R. M., Garon C. F., Nelson D. Isolation of papovavirus from brain tumor and urine of a patient with Wiskott-Aldrich syndrome. J Natl Cancer Inst. 1974 Nov;53(5):1205–1207. doi: 10.1093/jnci/53.5.1205. [DOI] [PubMed] [Google Scholar]
  16. Weiner L. P., Narayan O. Virologic studies of progressive multifocal leukoencephalopathy. Prog Med Virol. 1974;18(0):229–240. [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES