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. 1977 Nov;18(2):363–369. doi: 10.1128/iai.18.2.363-369.1977

Suppression of immunity to Mycobacterium lepraemurium infection.

M J Lefford, G B Mackaness
PMCID: PMC421241  PMID: 336544

Abstract

After injection of 10(8) live Mycobacterium lepraemurium (MLM) into the left hind footpad of mice, there is development of local swelling attributable to a granuloma of the cell-mediated immunity type. Concomitant intravenous inoculation of live MLM delays and may even suppress footpad swelling, the effects being proportional to the intravenous dose of organisms. Concomitant footpad infection and intravenous inoculation of 10(9) dead MLM also delays footpad swelling, but over a period of months the feet become excessively swollen. The excessive swelling is due to local enhancement of infection as evidenced by an increase in the number of MLM per footpad. Attempts were made to prevent such immunosuppression by splenectomy or treatment with BCG. Splenectomy was entirely without effect, but 10(7) live BCG administered intravenously 2 to 4 weeks before dead MLM prevented enhancement of infection. The mediator of the immunosuppressive mechanism that results in enhanced infection remains to be elucidated, but it is unlikely to be antibody or immune complexes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ambrose C. T., Donner A. Application of the analysis of variance to hemagglutination titrations. J Immunol Methods. 1973 Oct;3(2):165–209. doi: 10.1016/0022-1759(73)90031-8. [DOI] [PubMed] [Google Scholar]
  2. Baldwin R. W., Price M. R., Robins R. A. Inhibition of hepatoma-immune lymph-node cell cytotoxicity by tumour-bearer serum, and solubilized hepatoma antigen. Int J Cancer. 1973 May;11(3):527–535. doi: 10.1002/ijc.2910110304. [DOI] [PubMed] [Google Scholar]
  3. Closs O. Experimental murine leprosy: induction of immunity and immune paralysis to Mycobacterium lepraemurium in C57BL mice. Infect Immun. 1975 Oct;12(4):706–713. doi: 10.1128/iai.12.4.706-713.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Draper P. The walls of Mycobacterium lepraemurium: chemistry and ultrastructure. J Gen Microbiol. 1971 Dec;69(3):313–324. doi: 10.1099/00221287-69-3-313. [DOI] [PubMed] [Google Scholar]
  5. Gershon R. K. A disquisition on suppressor T cells. Transplant Rev. 1975;26:170–185. doi: 10.1111/j.1600-065x.1975.tb00179.x. [DOI] [PubMed] [Google Scholar]
  6. Hellström K. E., Hellström I. Immunological enhancement as studied by cell culture techniques. Annu Rev Microbiol. 1970;24:373–398. doi: 10.1146/annurev.mi.24.100170.002105. [DOI] [PubMed] [Google Scholar]
  7. Heppner G. H. Blocking antibodies and enhancement. Ser Haematol. 1972;5(4):41–66. [PubMed] [Google Scholar]
  8. Lagrange P. H., Mackaness G. B., Miller T. E. Influence of dose and route of antigen injection on the immunological induction of T cells. J Exp Med. 1974 Mar 1;139(3):528–542. doi: 10.1084/jem.139.3.528. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Mackaness G. B., Lagrange P. H., Ishibashi T. The modifying effect of BCG on the immunological induction of T cells. J Exp Med. 1974 Jun 1;139(6):1540–1552. doi: 10.1084/jem.139.6.1540. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Mackaness G. B., Lagrange P. H., Miller T. E., Ishibashi T. Feedback inhibition of specifically sensitized lymphocytes. J Exp Med. 1974 Mar 1;139(3):543–559. doi: 10.1084/jem.139.3.543. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Miller T. E., Mackaness G. B., Lagrange P. H. Immunopotentiation with BCG. II. Modulation of the response to sheep red blood cells. J Natl Cancer Inst. 1973 Nov;51(5):1669–1676. doi: 10.1093/jnci/51.5.1669. [DOI] [PubMed] [Google Scholar]
  12. Poulter L. W., Lefford M. J. Development of delayed-type hypersensitivity during Mycobacterium lepraemurium infection in mice. Infect Immun. 1977 Aug;17(2):439–446. doi: 10.1128/iai.17.2.439-446.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. ROWLEY D. A. The effect of splenectomy on the formation of circulating antibody in the adult male albino rat. J Immunol. 1950 Apr;64(4):289–295. [PubMed] [Google Scholar]
  14. Shepard C. C., McRae D. H. A method for counting acid-fast bacteria. Int J Lepr Other Mycobact Dis. 1968 Jan-Mar;36(1):78–82. [PubMed] [Google Scholar]
  15. Turk J. L., Bryceson A. D. Immunological phenomena in leprosy and related diseases. Adv Immunol. 1971;13:209–266. doi: 10.1016/s0065-2776(08)60185-6. [DOI] [PubMed] [Google Scholar]

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