Skip to main content
PMC home page
Infection and Immunity logoLink to Infection and Immunity
. 1977 Feb;15(2):343–346. doi: 10.1128/iai.15.2.343-346.1977

Host-parasite relationships in the yeastlike form of Paracoccidioides brasiliensis strain IVIC Pb9.

G San-Blas, F San-Blas, L E Serrano
PMCID: PMC421372  PMID: 844899

Abstract

The yeastlike form of Paracoccidioides brasiliensis strain IVIC Pb9 reduced the amount of alpha-1,3-glucan in its cell wall from 45 to 3% when subcultured in vitro for several years. This strain regained its alpha-1,3-glucan up to 25% of the total cell wall when grown in vivo. A mutant strain of P. brasiliensis Pb9, named IVIC Pb140, reported to have 1,3-mannan instead of alpha-glucan in the cell wall, could not be recovered from experimentally infected animals. The existence of some relationship between the presence of alpha-1,3-glucan in the cell wall of the yeastlike form and the pathogenicity of this fungus is suggested in this report.

Full text

PDF
345

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Azuma I., Kanetsuna F., Tanaka Y., Yamamura Y., Carbonell L. M. Chemical and immunological properties of galactomannans obtained from Histoplasma duboisii, Histoplasma capsulatum, Paracoccidioides brasiliensis and Blasomyces dermatitidis. Mycopathol Mycol Appl. 1974 Oct 15;54(1):111–125. doi: 10.1007/BF02055979. [DOI] [PubMed] [Google Scholar]
  2. Berliner M. D., Reca M. E. Vital staining of Histoplasma capsulatum with Janus Green B. Sabouraudia. 1966 Jun;5(1):26–29. [PubMed] [Google Scholar]
  3. Bulmer G. S., Sans M. D., Gunn C. M. Cryptococcus neoformans. I. Nonencapsulated mutants. J Bacteriol. 1967 Nov;94(5):1475–1479. doi: 10.1128/jb.94.5.1475-1479.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cox R. A., Best G. K. Cell wall composition of two strains of Blastomyces dermatitidis exhibiting differences in virulence for mice. Infect Immun. 1972 Apr;5(4):449–453. doi: 10.1128/iai.5.4.449-453.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Domer J. E. Monosaccharide and chitin content of cell walls of Histoplasma capsulatum and Blastomyces dermatitidis. J Bacteriol. 1971 Sep;107(3):870–877. doi: 10.1128/jb.107.3.870-877.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Ishaq C. M., Bulmer G. S., Felton F. G. An evaluation of various environmental factors affecting the propagation of Cryptococcus neoformas. Mycopathol Mycol Appl. 1968 Jul 12;35(2):81–90. doi: 10.1007/BF02049570. [DOI] [PubMed] [Google Scholar]
  7. Kanetsuna F., Carbonell L. M., Azuma I., Yamamura Y. Biochemical studies on the thermal dimorphism of Paracoccidioides brasiliensis. J Bacteriol. 1972 Apr;110(1):208–218. doi: 10.1128/jb.110.1.208-218.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kanetsuna F., Carbonell L. M. Cell wall composition of the yeastlike and mycelial forms of Blastomyces dermatitidis. J Bacteriol. 1971 Jun;106(3):946–948. doi: 10.1128/jb.106.3.946-948.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kanetsuna F., Carbonell L. M. Cell wall glucans of the yeast and mycelial forms of Paracoccidioides brasiliensis. J Bacteriol. 1970 Mar;101(3):675–680. doi: 10.1128/jb.101.3.675-680.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Kanetsuna F., Carbonell L. M., Gil F., Azuma I. Chemical and ultrastructural studies on the cell walls of the yeastlike and mycelial forms of Histoplasma capsulatum. Mycopathol Mycol Appl. 1974 Oct 15;54(1):1–13. doi: 10.1007/BF02055967. [DOI] [PubMed] [Google Scholar]
  11. Kanetsuna F., Carbonell L. M., Moreno R. E., Rodriguez J. Cell wall composition of the yeast and mycelial forms of Paracoccidioides brasiliensis. J Bacteriol. 1969 Mar;97(3):1036–1041. doi: 10.1128/jb.97.3.1036-1041.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. San-Blas F., Cova L. J. Growth curves of the yeast-like form of Paracocidioides bradiliensis. Sabouraudia. 1975 Mar;13(Pt 1):22–29. [PubMed] [Google Scholar]
  13. San-Blas F., San-Blas G., Cova L. J. A morphological mutant of Paracoccidioides brasiliensis strain IVIC Pb9. Isolation and wall characterization. J Gen Microbiol. 1976 Apr;93(2):209–218. doi: 10.1099/00221287-93-2-209. [DOI] [PubMed] [Google Scholar]
  14. San-Blas G., Carbonell L. M. Chemical and ultrastructural studies on the cell walls of the yeastlike and mycelial forms of Histoplasma farciminosum. J Bacteriol. 1974 Aug;119(2):602–611. doi: 10.1128/jb.119.2.602-611.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Zonneveld B. J. Alpha-1,3 glucan synthesis correlated with alpha-1,3 glucanase synthesis, conidiation and fructification in morphogenetic mutants of Aspergillus nidulans. J Gen Microbiol. 1974 Apr;81(2):445–451. doi: 10.1099/00221287-81-2-445. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES