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. 1977 Apr;16(1):54–59. doi: 10.1128/iai.16.1.54-59.1977

Passive immunity to feline leukemia: evaluation of immunity from dams naturally infected and experimentally vaccinated.

E A Hoover, J P Schaller, L E Mathes, R G Olsen
PMCID: PMC421487  PMID: 194840

Abstract

Antibodies against feline leukemia virus (FeLV) and the feline oncornavirus-associated cell membrane antigen (FOCMA) were transferred from pregnant cats to their suckling kittens. All of these kittens were protected against infection and oncogenesis by virulent FeLV when challenged at 2 weeks of age. Suckling kittens acquired 25 to 100% of maternal virus-neutralizing and FOCMA titers by 3 days of age, and titers underwent linear decay to undetectable levels by 2 to 3 months of age. FOCMA antibody in dams and kittens was identified as immunoglobulin G (IgG) by use of goat anti-human IgG serum, which cross-reacts with feline IgG in the indirect membrane immunofluorescence test for FOCMA antibody. In an attempt to induce protective maternal antibody by vaccination, 10 pregnant cats were immunized by three to five weekly intramuscular injections with purified FeLV inactivated by ultraviolet irradiation. After the course of immunization, neither virus-neutralizing nor FOCMA antibody was detectable in the dams or in 19 kittens born to these cats. When these kittens were challenged with FeLV at 2 weeks of age, 18 of 19 developed persistent viremia and FeLV-related disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Essex M. Horizontally and vertically transmitted oncornaviruses of cats. Adv Cancer Res. 1975;21:175–248. doi: 10.1016/s0065-230x(08)60973-2. [DOI] [PubMed] [Google Scholar]
  2. Essex M., Klein G., Snyder S. P., Harrold J. B. Antibody to feline oncornavirus-associated cell membrane antigen in neonatal cats. Int J Cancer. 1971 Nov 15;8(3):384–390. doi: 10.1002/ijc.2910080305. [DOI] [PubMed] [Google Scholar]
  3. Essex M., Sliski A., Hardy W. D., Jr, Cotter S. M. Immune response to leukemia virus and tumor-associated antigens in cats. Cancer Res. 1976 Feb;36(2 Pt 2):640–645. [PubMed] [Google Scholar]
  4. Essex M., Snyder S. P. Feline oncornavirus-associated cell membrane antigen. I. Serologic studies with kittens exposed to cell-free materials from various feline fibrosarcomas. J Natl Cancer Inst. 1973 Sep;51(3):1007–1012. doi: 10.1093/jnci/51.3.1007. [DOI] [PubMed] [Google Scholar]
  5. Essex M., Snyder S. P., Klein G. Relationship between humoral antibodies and the failure to develop progressive tumors in cats injected with feline sarcoma virus (FSV). Bibl Haematol. 1973;39:771–777. doi: 10.1159/000427905. [DOI] [PubMed] [Google Scholar]
  6. FRIEND C. Immunological relationships of a filterable agent causing a leukemia in adult mice. I. The neutralization of infectivity by specific antiserum. J Exp Med. 1959 Feb 1;109(2):217–228. doi: 10.1084/jem.109.2.217. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Fischinger P. J., Blevins C. S., Nomura S. Simple, quantitative assay for both xenotropic murine leukemia and ecotropic feline leukemia viruses. J Virol. 1974 Jul;14(1):177–179. doi: 10.1128/jvi.14.1.177-179.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hardy W. D., Jr, Hirshaut Y., Hess P. Detection of the feline leukemia virus and other mammalian oncornaviruses by immunofluorescence. Bibl Haematol. 1973;39:778–799. doi: 10.1159/000427906. [DOI] [PubMed] [Google Scholar]
  9. Hardy W. D., Jr, Old L. J., Hess P. W., Essex M., Cotter S. Horizontal transmission of feline leukaemia virus. Nature. 1973 Aug 3;244(5414):266–269. doi: 10.1038/244266a0. [DOI] [PubMed] [Google Scholar]
  10. Hoover E. A., Olsen R. G., Hardy W. D., Jr, Schaller J. P., Mathes L. E. Feline leukemia virus infection: age-related variation in response of cats to experimental infection. J Natl Cancer Inst. 1976 Aug;57(2):365–369. doi: 10.1093/jnci/57.2.365. [DOI] [PubMed] [Google Scholar]
  11. Ioachim H. L., Gimovsky M. L., Keller S. E., Gross L. Maternal vaccination with formalin-inactivated Gross lymphoma virus in rats and transfer of immunity to offspring. Proc Soc Exp Biol Med. 1973 Nov;144(2):376–379. doi: 10.3181/00379727-144-37595. [DOI] [PubMed] [Google Scholar]
  12. Jarrett W., Jarrett O., Mackey L., Laird H., Hardy W., Jr, Essex M. Horizontal transmission of leukemia virus and leukemia in the cat. J Natl Cancer Inst. 1973 Sep;51(3):833–841. doi: 10.1093/jnci/51.3.833. [DOI] [PubMed] [Google Scholar]
  13. Jarrett W., Jarrett O., Mackey L., Laird H., Hood C., Hay D. Vaccination against feline leukaemia virus using a cell membrane antigen system. Int J Cancer. 1975 Jul 15;16(1):134–141. doi: 10.1002/ijc.2910160115. [DOI] [PubMed] [Google Scholar]
  14. Kawakami T. G., Theilen G. H., Dungworth D. L., Munn R. J., Beall S. G. "C"-type viral particles in plasma of cats with feline leukemia. Science. 1967 Nov;158(3804):1049–1050. doi: 10.1126/science.158.3804.1049. [DOI] [PubMed] [Google Scholar]
  15. Mirand E. A., Grace J. T., Buffett R. F. Passive and active immunity to Friend virus disease. Nature. 1966 Feb 12;209(5024):696–698. doi: 10.1038/209696a0. [DOI] [PubMed] [Google Scholar]
  16. Olsen R. G., Hoover E. A., Mathes L. E., Heding L., Schaller J. P. Immunization against feline oncarnavirus disease using a killed tumor cell vaccine. Cancer Res. 1976 Oct;36(10):3642–3646. [PubMed] [Google Scholar]
  17. Sarma P. S., Log T. Subgroup classification of feline leukemia and sarcoma viruses by viral interference and neutralization tests. Virology. 1973 Jul;54(1):160–169. doi: 10.1016/0042-6822(73)90125-6. [DOI] [PubMed] [Google Scholar]
  18. Schaller J. P., Essex M., Yohn D. S., Olsen R. G. Feline oncornavirus-associated cell membrane antigen. V. Humoral immune response to virus and cell membrane antigens in cats inoculated with Gardner-Arnstein feline sarcoma virus. J Natl Cancer Inst. 1975 Dec;55(6):1373–1378. doi: 10.1093/jnci/55.6.1373. [DOI] [PubMed] [Google Scholar]
  19. Schaller J. P., Olsen R. G. Determination of subgroup-specific feline oncornavirus-neutralizing antibody. Infect Immun. 1975 Dec;12(6):1405–1410. doi: 10.1128/iai.12.6.1405-1410.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Schultz R. D., Scott F. W., Duncan J. R., Gillespie J. H. Feline immunoglobulins. Infect Immun. 1974 Feb;9(2):391–393. doi: 10.1128/iai.9.2.391-393.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Scott F. W., Csiza C. K., Gillespie J. H. Maternally derived immunity to feline panleukopenia. J Am Vet Med Assoc. 1970 Feb 15;156(4):439–453. [PubMed] [Google Scholar]
  22. Snyder S. P., Dungworth D. L. Pathogenesis of feline viral fibrosarcomas: dose and age effects. J Natl Cancer Inst. 1973 Sep;51(3):793–798. doi: 10.1093/jnci/51.3.793. [DOI] [PubMed] [Google Scholar]
  23. Theilen G. H., Kawakami T. G., Rush J. D., Munn R. J. Replication of cat leukemia virus in cell suspension cultures. Nature. 1969 May 10;222(5193):589–590. doi: 10.1038/222589b0. [DOI] [PubMed] [Google Scholar]
  24. Yohn D. S., Olsen R. G., Schaller J. P., Hoover E. A., Mathes L. E., Heding L., Davis G. W. Experimental oncornavirus vaccines in the cat. Cancer Res. 1976 Feb;36(2 Pt 2):646–651. [PubMed] [Google Scholar]

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