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. 1978 Oct;22(1):29–33. doi: 10.1128/iai.22.1.29-33.1978

Cold hemagglutinin cross-reactivity with Mycoplasma pneumoniae.

F A Janney, L T Lee, C Howe
PMCID: PMC422111  PMID: 83298

Abstract

Convalescent sera from proven cases of infection with Mycoplasma pneumoniae, and rabbit antisera to M. pneumoniae and to human erythrocyte glycoprotein contained cold hemagglutinins which were reactive only for human erythrocytes. Only the human serum cold agglutinins were inhibited by soluble integral glycoproteins derived from human erythrocyte ghosts by treatment with chloroform-methanol. Rabbit antiserum to chloroform-methanol glycoprotein, as well as to M. pneumoniae, fixed complement with either M. pneumoniae or chloroform-methanol glycoprotein antigens. The findings support the hypothesis that the cold agglutinins elicited by M. pneumoniae infection represent a cross-reaction between determinants common to erythrocyte glycoprotein containing I antigen and the membrane of M. pneumoniae.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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