Abstract
Virulence and infectivity of nine strains of Paracoccidioides brasiliensis were investigated in groups of mice which were inoculated intranasally or intravenously, and some of each were treated with corticosteroids. Fatal infections were not often seen among untreated mice, but mortality usually occurred when corticosteroids were given, regardless of the route of fungus inoculation. Prior treatment did not uniformly increase the incidence of infection, however; only in the case of intranasally inoculated mice was this effect seen. Most strains appeared to be more virulent when administered intravenously, with the exception of a single strain which, under the influence of corticosteroids, repeatedly displayed greatest virulence when given intranasally. All animals that died early in the course of the disease, irrespective of route of inoculation, always had acute pulmonary lesions and usually no other organ was involved. Animals which died later or were sacrificed always had chronic lung lesions. Whether or not chronically diseased animals had additional organ involvement correlated with how the organisms were administered; intravenously inoculated animals usually had extrapulmonary as well as pulmonary lesions, but lesions of those inoculated intranasally were almost exclusively pulmonary. Corticosteroids did not alter the histologic characteristics of either the acute or the chronic type of lesion, but the lesions of treated animals were usually more extensive. Most of the survivors appeared healthy even when infection was extensive.
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- Brass K. Observaciones sobre la anatomía patológica, patogénesis y evolución de la paracoccidioidomicosis. Mycopathol Mycol Appl. 1969 Mar 28;37(2):119–138. doi: 10.1007/BF02051694. [DOI] [PubMed] [Google Scholar]
- DA LACAZ C. S. South America blastomycosis. An Fac Med Univ Sao Paulo. 1955 1956;29:1–120. [PubMed] [Google Scholar]
- Filho M. C. Blastomicose sul-americana. Comentários em tôrno de 83 casos de localizaço pulmonar. Classificaço radiológica. Hospital (Rio J) 1966 Jul;70(1):109–134. [PubMed] [Google Scholar]
- Londero A. T. Aspectos de la blastomicosis sudamericana en Rio Grande do Sul, Brasil. Torax. 1968 Mar;17(1):56–59. [PubMed] [Google Scholar]
- MACKINNON J. E., CONTI DIAZ I. A., YARZABAL L. A., TAVELLA N. [Environmental temperature an South American blastomycosis]. An Fac Med Univ Repub Montev Urug. 1960;45:310–318. [PubMed] [Google Scholar]
- Mackinnon J. E. Actualización sobre patogenia de la blastomicosis sudamericana. Torax. 1968 Mar;17(1):40–45. [PubMed] [Google Scholar]
- NERY GUIMARAES F. Infecço do Hamster (Cricetus Auratus Waterhouse) pelo agente da micose de Lutz (blastomicose Sul-Americana); nota preliminar. Hospital (Rio J) 1951 Oct;40(4):515–520. [PubMed] [Google Scholar]
- RODRIGUEZ C., RINCON N. L., TROCONIS GARCIA G. [Contribution to the study of paracoccidiodomycosis brasiliensis in Venezuela. Considerations on 62 cases studied with special reference to respiratory localizations]. Mycopathol Mycol Appl. 1961 Aug 30;15:115–138. doi: 10.1007/BF02136321. [DOI] [PubMed] [Google Scholar]
- Restrepo A., Robledo M., Gutiérrez F., Sanclemente M., Castañeda E., Calle G. Paracoccidioidomycosis, (South American blastomycosis). A study of 39 cases observed in Medellin, Colombia. Am J Trop Med Hyg. 1970 Jan;19(1):68–76. [PubMed] [Google Scholar]
- SEGRETAIN G., DROUHET E. Blastomycoses expérimentales du hamster doré. Ann Inst Pasteur (Paris) 1955 Nov;89(5):593–596. [PubMed] [Google Scholar]
- SIDRANSKY H., FRIEDMAN L. The effect of cortisone and antibiotic agents on experimental pulmonary aspergillosis. Am J Pathol. 1959 Jan-Feb;35(1):169–183. [PMC free article] [PubMed] [Google Scholar]
- Teixeira G. de A., Machado Filho J., Miranda J. L. Blastomicose sul-americana experimental. Estudo experimental em ratos com consideraçes relativas à patogenia das lesões. Hospital (Rio J) 1965 Nov;68(5):1081–1096. [PubMed] [Google Scholar]
- de BRITO, NETTO C. F. Disseminated experimental South American blastomycosis of the guinea pig; a pathologic and immunologic study. Pathol Microbiol (Basel) 1963;26:29–43. doi: 10.1159/000161352. [DOI] [PubMed] [Google Scholar]