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. 1972 Jun;5(6):909–914. doi: 10.1128/iai.5.6.909-914.1972

Further Characterization of a Factor From Endotoxin-Treated Serum which Releases Histamine and Heparin from Mast Cells

William A Hook 1, Ralph Snyderman 1, Stephan E Mergenhagen 1
PMCID: PMC422462  PMID: 4117883

Abstract

Upon incubation of hamster serum with bacterial endotoxin, a factor is produced which releases histamine and heparin from hamster mast cells and increases capillary permeability in guinea pig skin. The major histamine-releasing activity derived from hamster serum was characterized by gel filtration, found to have a molecular weight of approximately 60,000, and shown by electrophoresis to migrate with alpha-2- or beta-1-globulins. The ability to increase vascular permeability was not reversed by antihistamine. On the basis of these properties, the histamine-liberating factor generated by endotoxin in hamster serum differed significantly from known anaphylatoxins.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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