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. 1972 Jun;5(6):957–960. doi: 10.1128/iai.5.6.957-960.1972

Respiratory Diseases in Cyclophosphamide-Treated Mice II. Decreased Virulence of PR8 Influenza Virus

S H Singer 1, P Noguchi 1, R L Kirschstein 1
PMCID: PMC422471  PMID: 4635505

Abstract

Mice infected intranasally with the PR8 strain of influenza virus were treated with cyclophosphamide, a potent immunologic suppressor. During the first week of infection, mortality in the unmodified influenza infection averaged 65%, whereas in those animals also treated with cyclophosphamide it averaged 22.5%. After the first week, the mortality rate in the infected cyclophosphamide-treated animals rose to that seen during the first week in the animals only infected. This decreased mortality in the first week was found despite the fact that the cyclophosphamide-treated and infected animals had higher virus titers which persisted longer, decreased circulating antibody, and a decreased interferon response. This delayed mortality appeared to be related to the finding of decreased cellular infiltration in the lungs of infected cyclophosphamide-treated animals.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baron S., Buckler C. E., Levy H. B., Friedman R. M. Some factors affecting the interferon-induced antiviral state. Proc Soc Exp Biol Med. 1967 Aug-Sep;125(4):1320–1326. doi: 10.3181/00379727-125-32347. [DOI] [PubMed] [Google Scholar]
  2. Cole G. A., Nathanson N. Potentiation of experimental arbovirus encephalitis by immunosuppressive doses of cyclophosphamide. Nature. 1968 Oct 26;220(5165):399–401. doi: 10.1038/220399a0. [DOI] [PubMed] [Google Scholar]
  3. GINSBERG H. S. Suppression of influenza viral pneumonia in mice by the non-specific action of xerosin. J Immunol. 1955 Dec;75(6):430–440. [PubMed] [Google Scholar]
  4. GROUPE V., PUGH L. H., LEVINE A. S. Suppression of viral pneumonia in mice by a microbial product (APM). Proc Soc Exp Biol Med. 1952 Aug-Sep;80(4):710–714. doi: 10.3181/00379727-80-19739. [DOI] [PubMed] [Google Scholar]
  5. ISAACS A., HITCHCOCK G. Role of interferon in recovery from virus infections. Lancet. 1960 Jul 9;2(7141):69–71. doi: 10.1016/s0140-6736(60)91215-0. [DOI] [PubMed] [Google Scholar]
  6. Murphy B. R., Glasgow L. A. Factors modifying host resistance to viral infection. I. Effect of immunosuppressive drugs on experimental infection of mice with encephalomyocarditis virus. Antimicrob Agents Chemother (Bethesda) 1967;7:661–667. doi: 10.1128/AAC.7.5.661. [DOI] [PubMed] [Google Scholar]
  7. Nathanson N., Cole G. A. Fatal Japanese encephalitis virus infection in immunosuppresed spider monkeys. Clin Exp Immunol. 1970 Jan;6(1):161–166. [PMC free article] [PubMed] [Google Scholar]
  8. Organick A. B., Siegesmund K. A., Lutsky I. I. Pneumonia due to mycoplasma in gnotobiotic mice. II. Localization of Mycoplasma pulmonis in the lungs of infected gnotobiotic mice by electron microscopy. J Bacteriol. 1966 Oct;92(4):1164–1176. doi: 10.1128/jb.92.4.1164-1176.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Singer S. H., Ford M., Kirschstein R. L. Respiratory diseases in cyclophosphamide-treated mice. I. Increased virulence of Mycoplasma pulmonis. Infect Immun. 1972 Jun;5(6):953–956. doi: 10.1128/iai.5.6.953-956.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Stockman G. D., Trentin J. J. Cyclophosphamide-induced tolerance to equine globulin and to equine-anti-mouse-thymocyte globulin in adult mice. I. Studies on antigen and drug requirements. J Immunol. 1972 Jan;108(1):112–118. [PubMed] [Google Scholar]
  11. Thind I. S., Price W. H. Recovery from primary infection with Langat E5 virus in normal and cyclophosphamide treated mice: relative roles of virus multiplication, interferon, antibody and serum protective factor. Am J Epidemiol. 1969 May;89(5):593–605. doi: 10.1093/oxfordjournals.aje.a120972. [DOI] [PubMed] [Google Scholar]
  12. Thind I. S., Price W. H. Role of serum protective factor (SPF) in Langat virus infection of neonatally thymectomized, cyclophosphamide-treated, or antilymphocyte-treated mice. J Immunol. 1969 Dec;103(6):1424–1427. [PubMed] [Google Scholar]
  13. Worthington M., Baron S. Effectiveness of an interferon stimulator in immunosuppressed mice. Proc Soc Exp Biol Med. 1971 Feb;136(2):349–353. doi: 10.3181/00379727-136-35262. [DOI] [PubMed] [Google Scholar]

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