Skip to main content
PMC home page
Infection and Immunity logoLink to Infection and Immunity
. 1972 Jul;6(1):38–42. doi: 10.1128/iai.6.1.38-42.1972

Serological Investigations of a Bovine Respiratory Disease (“Urner Pneumonie”) Resembling Farmer's Lung

J Nicolet a, R de Haller a, J Herzog a,1
PMCID: PMC422487  PMID: 4628862

Abstract

The immunological response of cattle exposed to moldy hay was examined by agar gel diffusion with standard farmer's lung hay antigens. A high incidence of precipitins against Micropolyspora faeni (60%) and moldy hay antigen (80%) was detected in exposed but apparently healthy cattle from a region with a high incidence of bovine farmer's lung. In comparison, in the plains, a low incidence area, we found only 1 animal of 164 harboring precipitins against M. faeni. We further observed that many animals from exposed populations lost their precipitins during pasturing and regained them during winter housing. Thirty-nine clinical cases of bovine farmer's lung (“Urner Pneumonie”) were investigated serologically. Only 49% of these animals showed precipitins against M. faeni and 54% showed precipitins against moldy hay antigen. We discuss in this paper the probable causes of this apparent lack of immunological response.

Full text

PDF
41

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Fletcher S. M., Rondle C. J., Murray I. G. The extracellular antigens of Micropolyspora faeni: their significance in farmer's lung disease. J Hyg (Lond) 1970 Sep;68(3):401–409. doi: 10.1017/s0022172400042303. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. GREGORY P. H., LACEY M. E. Mycological examination of dust from mouldy hay associated with farmer's lung disease. J Gen Microbiol. 1963 Jan;30:75–88. doi: 10.1099/00221287-30-1-75. [DOI] [PubMed] [Google Scholar]
  3. Harbourne J. F., Luery K. W., Wallace J. C., Threlkeld J. M. Farmer's lung hay antibodies in cattle. Vet Rec. 1970 Oct 31;87(18):559–560. doi: 10.1136/vr.87.18.559. [DOI] [PubMed] [Google Scholar]
  4. JENKINS P. A., PEPYS J. FOG-FEVER. PRECIPITIN (FLH) REACTIONS TO MOULDY HAY. Vet Rec. 1965 Apr 24;77:464–466. [PubMed] [Google Scholar]
  5. Lacey J. The microflora of fodders associated with bovine respiratory disease. J Gen Microbiol. 1968 Apr;51(2):173–177. doi: 10.1099/00221287-51-2-173. [DOI] [PubMed] [Google Scholar]
  6. Nicolet J., de Haller R., Scholer H. J. La pneumonie d'Uri: une pneumonie allergique au foin moisi chez le bovin. Pathol Microbiol (Basel) 1969;34(3):252–253. [PubMed] [Google Scholar]
  7. PEPYS J., JENKINS P. A., FESTENSTEIN G. N., GREGORY P. H., LACEY M. E., SKINNER F. A. FARMER'S LUNG. THERMOPHILIC ACTINOMYCETES AS A SOURCE OF "FARMER'S LUNG HAY" ANTIGEN. Lancet. 1963 Sep 21;2(7308):607–611. doi: 10.1016/s0140-6736(63)90398-2. [DOI] [PubMed] [Google Scholar]
  8. PEPYS J., JENKINS P. A. PRECIPITIN (F.L.H.) TEST IN FARMER'S LUNG. Thorax. 1965 Jan;20:21–35. doi: 10.1136/thx.20.1.21. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. PEPYS J., LONGBOTTOM J. L., JENKINS P. A. VEGETABLE DUST PNEUMOCONIOSES. IMMUNOLOGIC RESPONSES TO VEGETABLE DUSTS AND THEIR FLORA. Am Rev Respir Dis. 1964 Jun;89:842–858. doi: 10.1164/arrd.1964.89.6.842. [DOI] [PubMed] [Google Scholar]
  10. Pirie H. M., Dawson C. O., Breeze R. G., Wiseman A., Hamilton J. A bovine disease similar to farmer's lung: extrinsic allergic alveolitis. Vet Rec. 1971 Apr 3;88(14):346–351. doi: 10.1136/vr.88.14.346. [DOI] [PubMed] [Google Scholar]
  11. Walbaum S., Biguet J., Tran-Van-Ky P. Structure antigénique de Thermopolyspora polyspora. Répercussions pratiques sur le diagnostic du "poumon du fermier". Ann Inst Pasteur (Paris) 1969 Nov;117(5):673–693. [PubMed] [Google Scholar]
  12. de Haller R., Stump V., Scholer H. J., Nicolet J. Farmer's lung, Diskussioniagnostischer Kriterien an Hand einer Familienuntersuchung. Schweiz Med Wochenschr. 1969 Nov 29;99(48):1754–1759. [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES