Skip to main content
PMC home page
Infection and Immunity logoLink to Infection and Immunity
. 1973 Jun;7(6):911–917. doi: 10.1128/iai.7.6.911-917.1973

Interferon Sensitivity of Venezuelan Equine Encephalomyelitis Virus

George W Jordan 1
PMCID: PMC422782  PMID: 4577416

Abstract

Two strains of Venezuelan equine encephalomyelitis virus, which differ in virulence for mice, have been studied for their production of and sensitivity to chick and mouse interferon. Little interferon was produced by chick cells in response to the virulent Trinidad strain or the attenuated TC-83 strain without either aging or priming the cultures. Consistent differences in the production of chick interferon were not found between the two strains. Plaque variants of the Trinidad strain produced higher titers of mouse interferon than the TC-83 strain in both primed and control L-cell cultures. The TC-83 strain was found to be more sensitive than the Trinidad strain to the inhibitory effects of interferon. The greater sensitivity of the TC-83 strain was observed at both high and low multiplicities and for both chick and mouse interferons. These results are consistent with the hypothesis that interferon sensitivity may have a role as a determinant of virulence in some virus-host systems.

Full text

PDF
912

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ARCHETTI I., HORSFALL F. L., Jr Persistent antigenic variation of influenza A viruses after incomplete neutralization in ovo with heterologous immune serum. J Exp Med. 1950 Nov 1;92(5):441–462. doi: 10.1084/jem.92.5.441. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. FINTER N. B. INTERFERON PRODUCTION AND SENSITIVITY OF SEMLIKI FOREST VIRUS VARIANTS. J Hyg (Lond) 1964 Sep;62:337–349. doi: 10.1017/s0022172400040055. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Giron D. J. Role of interferon in the propagation of MM virus in L cells. Appl Microbiol. 1969 Oct;18(4):584–588. doi: 10.1128/am.18.4.584-588.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Inglot A. D., Lobodzińska M., Biernacka I., Niedźwiedzka E. Changes in the production of interferon in the process of adaptation of influenza type A2 virus to the mouse lung. Arch Immunol Ther Exp (Warsz) 1966;14(3):333–338. [PubMed] [Google Scholar]
  5. Jordan G. W. Quantitative aspects of interferon-induced plaque reduction: kinetics of interferon action. Virology. 1972 May;48(2):425–432. doi: 10.1016/0042-6822(72)90053-0. [DOI] [PubMed] [Google Scholar]
  6. LINK F., BLASKOVIC D., RAUS J. RELATIONSHIP BETWEEN VIRUS MULTIPLICATION AND INTERFERON PRODUCTION IN MOUSE LUNGS AFTER INFECTION WITH ADAPTED AND UNADAPTED INFLUENZA VIRUSES. Acta Virol. 1965 Jan;9:95–95. [PubMed] [Google Scholar]
  7. LOCKART R. Z., Jr PRODUCTION OF AN INTERFERON BY L CELLS INFECTED WITH WESTERN EQUINE ENCEPHALOMYELITIS VIRUS. J Bacteriol. 1963 Mar;85:556–566. doi: 10.1128/jb.85.3.556-566.1963. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. MCKINNEY R. W., BERGE T. O., SAWYER W. D., TIGERTT W. D., CROZIER D. USE OF AN ATTENUATED STRAIN OF VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS FOR IMMUNIZATION IN MAN. Am J Trop Med Hyg. 1963 Jul;12:597–603. doi: 10.4269/ajtmh.1963.12.597. [DOI] [PubMed] [Google Scholar]
  9. RUIZ-GOMEZ J., ISAACS A. Interferon production by different viruses. Virology. 1963 Jan;19:8–12. doi: 10.1016/0042-6822(63)90018-7. [DOI] [PubMed] [Google Scholar]
  10. Randall R., Mills J. W. FATAL ENCEPHALITIS IN MAN DUE TO THE VENEZUELAN VIRUS OF EQUINE ENCEPHALOMYELITIS IN TRINIDAD. Science. 1944 Mar 17;99(2568):225–226. doi: 10.1126/science.99.2568.225. [DOI] [PubMed] [Google Scholar]
  11. SELLERS R. F. Multiplication, interferon production and sensitivity of virulent and attenuated strains of the virus of foot-and-mouth disease. Nature. 1963 Jun 22;198:1228–1229. doi: 10.1038/1981228a0. [DOI] [PubMed] [Google Scholar]
  12. SELLERS R. F. VIRULENCE AND INTERFERON PRODUCTION OF STRAINS OF FOOT-AND MOUTH DISEASE VIRUS. J Immunol. 1964 Jul;93:6–12. [PubMed] [Google Scholar]
  13. TIGERTT W. D., DOWNS W. G. Studies on the virus of Venezuelan equine encephalomyelitis in Trinidad, W.I. I. The 1943-1944 epizootic. Am J Trop Med Hyg. 1962 Nov;11:822–834. doi: 10.4269/ajtmh.1962.11.822. [DOI] [PubMed] [Google Scholar]
  14. VAINIO T., GWATKIN R., KOPROWSKI H. Production of interferon by brains of genetically resistant and susceptible mice infected with West Nile virus. Virology. 1961 Jul;14:385–387. doi: 10.1016/0042-6822(61)90328-2. [DOI] [PubMed] [Google Scholar]
  15. VILCEK J. PRODUCTION OF INTERFERON BY NEWBORN AND ADULT MICE INFECTED WITH SINDBIS VIRUS. Virology. 1964 Apr;22:651–652. doi: 10.1016/0042-6822(64)90091-1. [DOI] [PubMed] [Google Scholar]
  16. WAGNER R. R., LEVEY A. H., SNYDER R. M., RATCLIFF G. A., Jr, HYATT D. F. BIOLOGIC PROPERTIES OF TWO PLAQUE VARIANTS OF VESICULAR STOMATITIS VIRUS (INDIANA SEROTYPE). J Immunol. 1963 Jul;91:112–122. [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES