Abstract
Streptococcal pyrogenic exotoxin (SPE) was shown previously to be a potent immunosuppressant. This paper presents data documenting that immunosuppression frequently was followed by elevated antibody and plaque-forming cell levels as noted in our earlier report. The data are interpreted as a differential effect of SPE upon suppressor T cells and secreting B cells.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Baker P. J., Stashak P. W., Amsbaugh D. F., Prescott B., Barth R. F. Evidence for the existence of two functionally distinct types of cells which regulate the antibody response to type 3 pneumococcal polysaccharide. J Immunol. 1970 Dec;105(6):1581–1583. [PubMed] [Google Scholar]
- Claman H. N., Chaperon E. A., Triplett R. F. Thymus-marrow cell combinations. Synergism in antibody production. Proc Soc Exp Biol Med. 1966 Aug-Sep;122(4):1167–1171. doi: 10.3181/00379727-122-31353. [DOI] [PubMed] [Google Scholar]
- DIXON F. J., McCONAHEY P. J. Enhancement of antibody formation by whole body x-radiation. J Exp Med. 1963 May 1;117:833–848. doi: 10.1084/jem.117.5.833. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hanna E. E., Watson D. W. Host-parasite relationships among group A streptococci. IV. Suppression of antibody response by streptococcal pyrogenic exotoxin. J Bacteriol. 1968 Jan;95(1):14–21. doi: 10.1128/jb.95.1.14-21.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kim Y. B., Watson D. W. A purified group A streptococcal pyrogenic exotoxin. Physiochemical and biological properties including the enhancement of susceptibility to endotoxin lethal shock. J Exp Med. 1970 Mar 1;131(3):611–622. doi: 10.1084/jem.131.3.611. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Okumura K., Tada T. Regulation of homocytotropic antibody formation in the rat. VI. Inhibitory effect of thymocytes on the homocytotropic antibody response. J Immunol. 1971 Dec;107(6):1682–1689. [PubMed] [Google Scholar]
- Sterzl J., Ríha I. Detection of cells producing 7S antibodies by the plaque technique. Nature. 1965 Nov 27;208(5013):858–859. doi: 10.1038/208858a0. [DOI] [PubMed] [Google Scholar]
- TALIAFERRO W. H., TALIAFERRO L. G. ENHANCEMENT OF NATURAL HEMOLYSIN IN ADULT RABBITS AFTER RADIATION. Proc Natl Acad Sci U S A. 1965 Jan;53:139–146. doi: 10.1073/pnas.53.1.139. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Yoshinaga M., Yoshinaga A., Waksman B. H. Regulation of lymphocyte responses in vitro: potentiation and inhibition of rat lymphocyte responses to antigen and mitogens by cytochalasin B. Proc Natl Acad Sci U S A. 1972 Nov;69(11):3251–3255. doi: 10.1073/pnas.69.11.3251. [DOI] [PMC free article] [PubMed] [Google Scholar]